STRINGSTRING
casp3a casp3a gli2a gli2a robo2 robo2 pik3cd pik3cd slc35b2 slc35b2 rb1 rb1 lamc1 lamc1 mycbp2 mycbp2 pigk pigk mapk14a mapk14a casp9 casp9 slc25a46 slc25a46 pard6gb pard6gb disp1 disp1 ptch2 ptch2 cybb cybb ext2 ext2 adcy8 adcy8 slc17a6b slc17a6b boc boc slit1a slit1a dzip1 dzip1 pard3ab pard3ab lhx2b lhx2b ahi1 ahi1 extl3 extl3 cyfip2 cyfip2 gli1 gli1 lamb1a lamb1a mib1 mib1 lama1 lama1 pik3ca pik3ca slbp slbp ndr2 ndr2 dagla dagla
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
robo2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (1387 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
slc35b2Solute carrier family 35, member B2. (435 aa)
rb1Retinoblastoma 1. (903 aa)
lamc1Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa)
mycbp2E3 ubiquitin-protein ligase MYCBP2; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probabl [...] (4574 aa)
pigkGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (389 aa)
mapk14aMitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
slc25a46Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission. (405 aa)
pard6gbPar-6 partitioning defective 6-like protein gamma. (434 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
cybbCytochrome b-245, beta polypeptide (chronic granulomatous disease). (565 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
adcy8Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (892 aa)
slc17a6bVesicular glutamate transporter 2.1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. Required for glutamate release by retinotectal synapses and visual acuity. (584 aa)
bocBOC cell adhesion-associated, oncogene-regulated. (1032 aa)
slit1aSlit homolog 1a (Drosophila). (1524 aa)
dzip1Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa)
pard3abPar-3 family cell polarity regulator alpha, b. (1332 aa)
lhx2bLIM homeobox 2b. (427 aa)
ahi1Abelson helper integration site 1. (1193 aa)
extl3Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (917 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa)
gli1GLI family zinc finger 1. (1404 aa)
lamb1aLaminin, beta 1a. (1785 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
lama1Laminin, alpha 1. (3075 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
slbpStem-loop-binding protein. (302 aa)
ndr2Nodal-related 2. (505 aa)
daglaDiacylglycerol lipase, alpha. (1076 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.