STRINGSTRING
dmd dmd prdm1a prdm1a her7 her7 gli2a gli2a smo smo dag1 dag1 gmppb gmppb orai1b orai1b unc45b unc45b tcap tcap dpf3 dpf3 scube2 scube2 hdac3 hdac3 atoh8 atoh8 fer1l6 fer1l6 cacnb1 cacnb1 lurap1 lurap1 disp1 disp1 b3galnt2 b3galnt2 ctsd ctsd gars1 gars1 fktn fktn col6a2 col6a2 ripor2 ripor2 myo18ab myo18ab ambra1a ambra1a itga6a itga6a blzf1 blzf1 col6a4a col6a4a elp3 elp3 arhgef28a arhgef28a mef2aa mef2aa myof myof selenon selenon las1l las1l lamb2 lamb2 fxr1 fxr1 apobec2a apobec2a shha shha synpo2lb synpo2lb ambra1b ambra1b sil1 sil1 lama2 lama2 fkrp fkrp ntn1a ntn1a mibp2 mibp2 lama1 lama1 adss1 adss1 itgb1b itgb1b dcc dcc thsd7aa thsd7aa tbcd tbcd hspg2 hspg2 cav1 cav1 obscnb obscnb apobec2b apobec2b megf10 megf10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dmdDystrophin. (594 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
her7Hairy and enhancer of split-related-7. (206 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
dag1Dystroglycan 1. (866 aa)
gmppbMannose-1-phosphate guanyltransferase beta; Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. (360 aa)
orai1bCalcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores; Belongs to the Orai family. (222 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
tcapTitin-cap (telethonin). (179 aa)
dpf3Zinc finger protein DPF3; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). Plays an essential role in heart and skeletal [...] (391 aa)
scube2Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa)
hdac3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa)
atoh8Protein atonal homolog 8; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). During development, is required for heart looping and swim bladder formation by acting in concert with GATA4 AND ZFPM1. During the development of both the retina and skeletal muscles is required for neural retinal cell through modulating PAX6 and NEUROG3 expression and myogenic differentiation. (266 aa)
fer1l6Fer-1-like family member 6. (1790 aa)
cacnb1Calcium channel, voltage-dependent, beta 1 subunit. (603 aa)
lurap1Leucine-rich adaptor protein 1. (286 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
b3galnt2UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O- glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (dag1) glycosylation; Belongs to the glycosyltransferase 31 family. (491 aa)
ctsdCtsd protein; Belongs to the peptidase A1 family. (398 aa)
gars1Glycyl-tRNA synthetase. (690 aa)
fktnFukutin. (457 aa)
col6a2Collagen, type VI, alpha 2. (1015 aa)
ripor2Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis an [...] (1083 aa)
myo18abMyosin XVIIIAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2557 aa)
ambra1aActivating molecule in beclin-1-regulated autophagy. (1315 aa)
itga6aIntegrin, alpha 6a; Belongs to the integrin alpha chain family. (1092 aa)
blzf1Basic leucine zipper nuclear factor 1. (394 aa)
col6a4aCollagen, type VI, alpha 4a. (2543 aa)
elp3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] (533 aa)
arhgef28aRho guanine nucleotide exchange factor (GEF) 28a. (1753 aa)
mef2aaMyocyte enhancer factor 2aa. (458 aa)
myofMyoferlin. (2030 aa)
selenonSelenoprotein N; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Plays an important role [...] (557 aa)
las1lLAS1-like ribosome biogenesis factor. (580 aa)
lamb2Laminin, beta 2 (laminin S). (1782 aa)
fxr1Fragile X mental retardation, autosomal homolog 1. (645 aa)
apobec2aApolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2a. (266 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
synpo2lbSynaptopodin 2-like b. (1184 aa)
ambra1bAutophagy/beclin-1 regulator 1b. (1360 aa)
sil1SIL1 nucleotide exchange factor. (463 aa)
lama2Laminin, alpha 2. (845 aa)
fkrpFukutin-related protein. (536 aa)
ntn1aNetrin-1a. (603 aa)
mibp2Muscle-specific beta 1 integrin-binding protein 2. (203 aa)
lama1Laminin, alpha 1. (3075 aa)
adss1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (456 aa)
itgb1bIntegrin beta; Belongs to the integrin beta chain family. (521 aa)
dccDCC netrin 1 receptor. (1200 aa)
thsd7aaThrombospondin type-1 domain-containing protein 7A; Required for normal sprouting angiogenesis and normal embryonic development of intersegmental vessels (ISV). Required for normal function of the glomerular filtration barrier. Required for normal axon outgrowth on embryonic motor neurons at the level of the horizontal myoseptum. Required for normal expression of notch1b, suggesting that its functions in angiogenesis and neuron outgrowth are due to decreased expression of notch1b. Plays a role in actin cytoskeleton rearrangement (By similarity). (1684 aa)
tbcdTubulin folding cofactor D. (1191 aa)
hspg2Heparan sulfate proteoglycan 2. (3462 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
obscnbObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b. (1660 aa)
apobec2bApolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2b. (273 aa)
megf10Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.