STRINGSTRING
hey2 hey2 nkx2.7 nkx2.7 snx13 snx13 hand2 hand2 ezh2 ezh2 flncb flncb lbx2 lbx2 mmd mmd lrrc39 lrrc39 smarce1 smarce1 mpp5a mpp5a obscnb obscnb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hey2Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. (324 aa)
nkx2.7NK2 transcription factor-related 7. (269 aa)
snx13Sorting nexin 13. (955 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
ezh2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa)
flncbFilamin C, gamma b (actin-binding protein 280). (2773 aa)
lbx2Ladybird homeobox homolog 2 (Drosophila). (257 aa)
mmdMonocyte to macrophage differentiation-associated. (239 aa)
lrrc39Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress (By similarity). May regulate expression of other M-band proteins via an SRF-dependent pathway (By similarity). Important for normal contractile function in heart. (343 aa)
smarce1SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily e, member 1. (420 aa)
mpp5aMAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa)
obscnbObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b. (1660 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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