STRINGSTRING
fgf10a fgf10a hdac3 hdac3 sulf1 sulf1 rspo3 rspo3 epcam epcam ildr1b ildr1b tgfb1a tgfb1a snai1b snai1b ext2 ext2 lmln lmln kremen1 kremen1 src src f11r.1 f11r.1 gnb1a gnb1a lef1 lef1 aldh1l1 aldh1l1 sh3pxd2aa sh3pxd2aa gata4 gata4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf10aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
hdac3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa)
sulf1Sulfatase FP1c. (1099 aa)
rspo3R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and prunin [...] (317 aa)
epcamEpithelial cell adhesion molecule. (303 aa)
ildr1bImmunoglobulin-like domain-containing receptor 1b. (551 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
snai1bSnail family zinc finger 1b. (256 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
lmlnLeishmanolysin-like peptidase. (664 aa)
kremen1Kringle-containing transmembrane protein 1. (465 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
f11r.1F11 receptor, tandem duplicate 1. (292 aa)
gnb1aGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). (340 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
aldh1l110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (903 aa)
sh3pxd2aaSH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation; Belongs to the SH3PXD2 family. (1085 aa)
gata4GATA-binding protein 4. (352 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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