STRINGSTRING
sec63 sec63 erbb2 erbb2 lingo1b lingo1b vps11 vps11 bace2 bace2 leo1 leo1 kifbp kifbp actr10 actr10 exosc8 exosc8 tuba8l3 tuba8l3 abhd12 abhd12 sox10 sox10 abcd1 abcd1 mtor mtor fbxw7 fbxw7 chd7 chd7 adgrg6 adgrg6 l1camb l1camb prnprs3 prnprs3 ndrg4 ndrg4 bace1 bace1 lama2 lama2 hmgcs1 hmgcs1 dock1 dock1 dync1h1 dync1h1 adgrg1 adgrg1 etfa etfa rraga rraga tfeb tfeb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sec63SEC63 homolog, protein translocation regulator. (751 aa)
erbb2Receptor protein-tyrosine kinase. (1275 aa)
lingo1bLeucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. (622 aa)
vps11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa)
bace2Zgc:103530 protein; Belongs to the peptidase A1 family. (372 aa)
leo1RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. (696 aa)
kifbpKIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. (631 aa)
actr10Actin-related protein 10; Belongs to the actin family. (415 aa)
exosc8Exosome component 8. (277 aa)
tuba8l3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
abhd12Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase act [...] (382 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
abcd1ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination. (766 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
fbxw7F-box and WD repeat domain-containing 7. (544 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
adgrg6Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development. (1240 aa)
l1cambNeural cell adhesion molecule L1.1; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1332 aa)
prnprs3Prion protein,-related sequence 3. (559 aa)
ndrg4NDRG family member 4. (352 aa)
bace1Beta-secretase 1; Belongs to the peptidase A1 family. (221 aa)
lama2Laminin, alpha 2. (845 aa)
hmgcs13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa)
dock1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1840 aa)
dync1h1Dynein, cytoplasmic 1, heavy chain 1. (1765 aa)
adgrg1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (648 aa)
etfaElectron-transfer-flavoprotein, alpha polypeptide. (333 aa)
rragaRas-related GTP-binding A. (316 aa)
tfebTranscription factor EB. (493 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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