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hey2 hey2 gfi1aa gfi1aa noto noto pkd2 pkd2 lbx2 lbx2 prrx1a prrx1a gdf3 gdf3 cftr cftr DNAH10 DNAH10 jam3b jam3b rnf115 rnf115 galnt11 galnt11 slc25a25b slc25a25b numb numb pbx4 pbx4 cdx4 cdx4 pacrg pacrg bmp2b bmp2b atp6ap1b atp6ap1b tctn2 tctn2 wnt8a wnt8a atr atr cntrob cntrob mespbb mespbb lamb1a lamb1a scube1 scube1 tbxta tbxta mmp21 mmp21 npas4l npas4l ripply1 ripply1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hey2Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. (324 aa)
gfi1aaGrowth factor-independent 1A transcription repressor a. (385 aa)
notoNotochord homeobox. (241 aa)
pkd2Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...] (904 aa)
lbx2Ladybird homeobox homolog 2 (Drosophila). (257 aa)
prrx1aPaired-related homeobox 1a. (245 aa)
gdf3Protein DVR-1; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. (355 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1485 aa)
DNAH10Dynein axonemal heavy chain 10. (4626 aa)
jam3bJunctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. (333 aa)
rnf115Ring finger protein 115. (310 aa)
galnt11Polypeptide N-acetylgalactosaminyltransferase. (590 aa)
slc25a25bCalcium-binding mitochondrial carrier protein SCaMC-2-B; Calcium-dependent mitochondrial solute carrier. Belongs to the mitochondrial carrier (TC 2.A.29) family. (524 aa)
numbNUMB endocytic adaptor protein. (680 aa)
pbx4Pre-B-cell leukemia transcription factor 4. (343 aa)
cdx4Caudal type homeo box transcription factor 4. (270 aa)
pacrgPARK2 co-regulated. (236 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
atp6ap1bATPase H+-transporting accessory protein 1b. (459 aa)
tctn2Tectonic family member 2. (709 aa)
wnt8aProtein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
cntrobCentrobin, centrosomal BRCA2-interacting protein. (77 aa)
mespbbMesoderm posterior bb. (244 aa)
lamb1aLaminin, beta 1a. (1785 aa)
scube1Signal peptide, CUB domain, EGF-like 1. (1067 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
mmp21Matrix metallopeptidase-21; Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway; Belongs to the peptidase M10A family. (599 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
ripply1Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. (140 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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