STRINGSTRING
cdh2 cdh2 fgf8a fgf8a fgf16 fgf16 kctd13 kctd13 gas2l3 gas2l3 fgf22 fgf22 auts2a auts2a nlk2 nlk2 lef1 lef1 pcdh19 pcdh19 fgfr2 fgfr2 cad cad znf644a znf644a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
fgf16Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa)
kctd13BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (By similarity). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission. (330 aa)
gas2l3Growth arrest-specific 2-like 3. (550 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
auts2aActivator of transcription and developmental regulator AUTS2 a. (1278 aa)
nlk2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
pcdh19Protocadherin 19. (1088 aa)
fgfr2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa)
cadCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2230 aa)
znf644aZinc finger protein 644a. (1169 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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