STRINGSTRING
foxi3b foxi3b prdm12b prdm12b ctr9 ctr9 bmp7a bmp7a racgap1 racgap1 noto noto ppdpfa ppdpfa klf2a klf2a fzd8a fzd8a foxh1 foxh1 foxi3a foxi3a ihhb ihhb evx2 evx2 adgra2 adgra2 tbx2b tbx2b mixl1 mixl1 rtf1 rtf1 nr2e3 nr2e3 polr1c polr1c tmem88a tmem88a her5 her5 disc1 disc1 mych mych med12 med12 nrg1 nrg1 mib1 mib1 sox32 sox32 evx1 evx1 eomesa eomesa klf2b klf2b nkx2.2a nkx2.2a tfap2a tfap2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
foxi3bForkhead box I3b. (383 aa)
prdm12bPR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (366 aa)
ctr9CTR9 homolog, Paf1/RNA polymerase II complex component. (1160 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
racgap1Rac GTPase-activating protein 1. (654 aa)
notoNotochord homeobox. (241 aa)
ppdpfaPancreatic progenitor cell differentiation and proliferation factor A; Probable regulator of exocrine pancreas development. (117 aa)
klf2aKruppel-like factor 2a. (380 aa)
fzd8aFrizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
foxh1Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
foxi3aForkhead box I3a. (353 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
evx2Even-skipped homeobox 2. (418 aa)
adgra2Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] (1367 aa)
tbx2bT-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa)
mixl1Mix paired-like homeobox. (327 aa)
rtf1RTF1 homolog, Paf1/RNA polymerase II complex component. (701 aa)
nr2e3Nuclear receptor subfamily 2, group E, member 3. (426 aa)
polr1cRNA polymerase I and III subunit C. (362 aa)
tmem88aTransmembrane protein 88 a. (219 aa)
her5Hairy-related 5. (214 aa)
disc1DISC1 scaffold protein. (994 aa)
mychTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (360 aa)
med12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa)
nrg1Neuregulin 1. (730 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
sox32SRY-box transcription factor 32. (307 aa)
evx1Even-skipped homeobox 1. (377 aa)
eomesaT-box transcription factor eomesodermin. (661 aa)
klf2bKruppel-like factor 2b. (363 aa)
nkx2.2aHomeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa)
tfap2aTranscription factor AP-2 alpha. (450 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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