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| | nsd2 | Nuclear receptor-binding SET domain protein 2. (1461 aa) |
| | prdm1a | PR domain-containing 1a, with ZNF domain. (776 aa) |
| | sox9a | HMG box transcription factor Sox9a. (462 aa) |
| | gpc4 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | cpsf4 | Cleavage and polyadenylation-specific factor 4. (271 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | dlx1a | Homeobox protein Dlx1a. (252 aa) |
| | usp20 | Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2). Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the pe [...] (911 aa) |
| | colec11 | Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis [...] (271 aa) |
| | gata3 | Transcription factor GATA-3. (438 aa) |
| | dvl2 | Dishevelled segment polarity protein 2. (747 aa) |
| | zic2a | ZIC family member 2 (Odd-paired homolog, Drosophila), A. (445 aa) |
| | frzb | Frizzled-related protein. (315 aa) |
| | eftud2 | Elongation factor Tu GTP-binding domain-containing 2. (973 aa) |
| | faf1 | Fas (TNFRSF6)-associated factor 1. (675 aa) |
| | sparc | Secreted protein, acidic, cysteine-rich (osteonectin). (291 aa) |
| | tbx1 | T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa) |
| | mmp14b | Matrix metallopeptidase 14b (membrane-inserted). (621 aa) |
| | adarb1a | Adenosine deaminase RNA-specific B1a. (720 aa) |
| | fgf10a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | kmt2d | Lysine (K)-specific methyltransferase 2D. (3325 aa) |
| | smad5 | Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa) |
| | nr3c1 | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa) |
| | pkdccb | Protein kinase domain-containing, cytoplasmic b. (481 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | arl6ip1 | ADP-ribosylation factor-like 6-interacting protein 1. (203 aa) |
| | vgll2a | Vestigial-like family member 2a. (296 aa) |
| | usp39 | Ubiquitin-specific peptidase 39. (497 aa) |
| | sox9b | HMG box transcription factor Sox9b. (407 aa) |
| | disp1 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa) |
| | nansa | N-acetylneuraminic acid synthase a. (359 aa) |
| | cnbpa | CCHC-type zinc finger, nucleic acid-binding protein a. (163 aa) |
| | rx3 | Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa) |
| | pax9 | Paired box 9. (343 aa) |
| | leo1 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. (696 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | uxs1 | UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Essential during embryogenesis for craniofacial development. Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (418 aa) |
| | fgfrl1a | Fibroblast growth factor receptor-like 1a. (483 aa) |
| | gpatch3 | G patch domain-containing 3. (669 aa) |
| | mecom | MDS1 and EVI1 complex locus. (766 aa) |
| | tinagl1 | Tubulointerstitial nephritis antigen-like 1; Belongs to the peptidase C1 family. (471 aa) |
| | edaradd | EDAR-associated death domain. (219 aa) |
| | kat2b | Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa) |
| | bap1 | Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). (755 aa) |
| | wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | tcf7l1a | Transcription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa) |
| | dmrt2b | Doublesex and mab-3-related transcription factor 2b. (364 aa) |
| | nolc1 | Nucleolar and coiled-body phosphoprotein 1. (1001 aa) |
| | gria2a | Glutamate receptor, ionotropic, AMPA 2a. (875 aa) |
| | pdgfra | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa) |
| | skib | V-ski avian sarcoma viral oncogene homolog b. (695 aa) |
| | uchl3 | Ubiquitin carboxyl-terminal hydrolase. (230 aa) |
| | chsy1 | Hexosyltransferase. (801 aa) |
| | pdgfaa | Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (194 aa) |
| | ahr2 | Aryl hydrocarbon receptor 2. (1027 aa) |
| | tshz2 | Teashirt zinc finger homeobox 2. (1020 aa) |
| | boc | BOC cell adhesion-associated, oncogene-regulated. (1032 aa) |
| | cyp26b1 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa) |
| | rerea | Arginine-glutamic acid dipeptide (RE) repeats a. (1531 aa) |
| | dlx2a | Homeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa) |
| | pappa2 | Pappalysin 2. (1731 aa) |
| | usp18 | Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. (337 aa) |
| | usp44 | Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key role in the spindle assembly checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity). (695 aa) |
| | dzip1 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa) |
| | wnt9a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa) |
| | fzd7a | Frizzled class receptor 7a; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa) |
| | prdm5 | PR domain-containing 5. (634 aa) |
| | fgf20b | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | cyldb | Cylindromatosis (turban tumor syndrome), b. (694 aa) |
| | foxd3 | Forkhead box D3. (371 aa) |
| | prdm16 | Si:ch211-263k4.2. (927 aa) |
| | loxl3b | Lysyl oxidase homolog 3B; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (By similarity). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (By similarity). Can mediate oxidation of lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues (By similarity). Required for maturation of neural crest derived car [...] (807 aa) |
| | sp7 | Sp7 transcription factor. (528 aa) |
| | crispld2 | Cysteine-rich secretory protein LCCL domain-containing 2. (512 aa) |
| | pknox1.1 | Homeodomain transcription factor Prep1. (433 aa) |
| | polr1c | RNA polymerase I and III subunit C. (362 aa) |
| | enpp1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa) |
| | esf1 | ESF1, nucleolar pre-rRNA-processing protein, homolog (S. cerevisiae). (757 aa) |
| | macc1 | MET transcriptional regulator MACC1. (853 aa) |
| | rbms3 | RNA-binding motif, single stranded-interacting protein. (409 aa) |
| | kdm6a | Lysine (K)-specific demethylase 6A. (1390 aa) |
| | ift80 | Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa) |
| | specc1lb | Sperm antigen with calponin homology and coiled-coil domains 1-like b. (1121 aa) |
| | alx1 | ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Required for proper neural crest cell migration into the frontonasal primordia during development ; Belongs to the paired homeobox family. (320 aa) |
| | tnfaip3 | Tumor necrosis factor, alpha-induced protein 3. (756 aa) |
| | cylda | Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (951 aa) |
| | tgfb2 | Transforming growth factor, beta 2. (413 aa) |
| | pcdh19 | Protocadherin 19. (1088 aa) |
| | usp5 | Ubiquitin carboxyl-terminal hydrolase. (834 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | col11a2 | Collagen, type XI, alpha 2. (1803 aa) |
| | eif3f | Eukaryotic translation initiation factor 3, subunit F; Belongs to the eIF-3 subunit F family. (282 aa) |
| | ostn | Osteocrin. (134 aa) |
| | nomo | Nodal modulator. (1208 aa) |
| | gli1 | GLI family zinc finger 1. (1404 aa) |
| | polr1a | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1693 aa) |
| | Usp15 | DUSP domain-containing protein. (143 aa) |
| | hmgcrb | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa) |
| | foxi1 | Forkhead box I1. (377 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | rbm24a | RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (230 aa) |
| | hdac4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa) |
| | ttc8 | Tetratricopeptide repeat domain 8. (268 aa) |
| | fzd6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (617 aa) |
| | smchd1 | Structural maintenance of chromosomes flexible hinge domain-containing 1. (1983 aa) |
| | capzb | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa) |
| | esrra | Estrogen-related receptor alpha. (436 aa) |
| | msx1a | Muscle segment homeobox 1a. (233 aa) |
| | ndnf | Neuron-derived neurotrophic factor. (585 aa) |
| | kat2a | Histone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for [...] (819 aa) |
| | tfap2a | Transcription factor AP-2 alpha. (450 aa) |
