STRINGSTRING
rnf2 rnf2 sox9a sox9a jag1b jag1b fgf8a fgf8a slc35b2 slc35b2 ptch1 ptch1 tgfb3 tgfb3 panx3 panx3 emx2 emx2 sox9b sox9b atp2b1a atp2b1a uxs1 uxs1 ext2 ext2 ihha ihha furina furina plcb3 plcb3 mef2ca mef2ca edn1 edn1 acvr2aa acvr2aa gba gba rspo2 rspo2 cyp26b1 cyp26b1 acvr2ba acvr2ba sp7 sp7 notch2 notch2 sbds sbds b3gat3 b3gat3 grem2b grem2b brpf1 brpf1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rnf2E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa)
sox9aHMG box transcription factor Sox9a. (462 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
slc35b2Solute carrier family 35, member B2. (435 aa)
ptch1Protein patched homolog 1. (1475 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
panx3Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (444 aa)
emx2Empty spiracles homeobox 2. (247 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
atp2b1aCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1228 aa)
uxs1UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Essential during embryogenesis for craniofacial development. Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (418 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
furinaFurin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (806 aa)
plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1244 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
edn1Endothelin 1. (188 aa)
acvr2aaSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (538 aa)
gbaGlucosylceramidase. (518 aa)
rspo2R-spondin 2_variant1. (248 aa)
cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa)
acvr2baSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
sp7Sp7 transcription factor. (528 aa)
notch2Notch receptor 2. (2475 aa)
sbdsSBDS ribosome maturation factor. (250 aa)
b3gat3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (330 aa)
grem2bGremlin. (166 aa)
brpf1Bromodomain and PHD finger-containing, 1. (1248 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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