STRINGSTRING
pdhb pdhb ddc ddc chm chm chrna1 chrna1 lamc1 lamc1 chata chata cdh23 cdh23 crx crx glra4a glra4a pigk pigk tmc2b tmc2b glra1 glra1 atat1 atat1 ache ache dhdds dhdds pglyrp5 pglyrp5 ifng1r ifng1r glrbb glrbb c1ql4l c1ql4l slc6a9 slc6a9 lhfpl5b lhfpl5b slc17a8 slc17a8 mtmr14 mtmr14 cplx4a cplx4a cep131 cep131 cnnm2a cnnm2a nyx nyx atp1b2b atp1b2b atp6v0d1 atp6v0d1 atoh7 atoh7 nbeaa nbeaa nsfa nsfa cdipt cdipt cnnm2b cnnm2b pigu pigu get1 get1 akap12b akap12b col6a1 col6a1 cfap298 cfap298 bbs4 bbs4 ush1c ush1c adcy1b adcy1b tmie tmie pax5 pax5 pkd2l1 pkd2l1 synj1 synj1 ifng1 ifng1 slc26a2 slc26a2 grhl1 grhl1 grhl2b grhl2b cyfip2 cyfip2 mtm1 mtm1 pcdh15a pcdh15a eya4 eya4 lamb1a lamb1a cacna1ab cacna1ab nos1 nos1 arnt2 arnt2 clrn1 clrn1 tomt tomt denr denr cntn2 cntn2 robo3 robo3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdhbPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
ddcDopa decarboxylase. (480 aa)
chmRab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa)
chrna1Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa)
lamc1Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa)
chataCholine O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Belongs to the carnitine/choline acetyltransferase family. (637 aa)
cdh23Cadherin-related 23. (2883 aa)
crxCone-rod homeobox. (281 aa)
glra4aGlycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
pigkGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (389 aa)
tmc2bTransmembrane channel-like protein 2-B; Belongs to the TMC family. (892 aa)
glra1Glycine receptor subunit alphaZ1; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity); Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily. (459 aa)
atat1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (305 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
dhddsAlkyl transferase; Belongs to the UPP synthase family. (335 aa)
pglyrp5Peptidoglycan recognition protein 5. (238 aa)
ifng1rInterferon gamma-related. (170 aa)
glrbbGlycine receptor beta subunit 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (494 aa)
c1ql4lCerebellin 5. (213 aa)
slc6a9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (653 aa)
lhfpl5bLHFPL tetraspan subfamily member 5b. (221 aa)
slc17a8Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. (590 aa)
mtmr14Myotubularin-related protein 14. (630 aa)
cplx4aSi:ch211-233a1.5. (159 aa)
cep131Centrosomal protein of 131 kDa; Cilium-specific protein required for the regulation of cilium/flagellum formation. Involved in centriole duplication (By similarity). May play a role in melanosome trafficking ; Belongs to the CEP131 family. (1111 aa)
cnnm2aCyclin and CBS domain divalent metal cation transport mediator 2a. (811 aa)
nyxNyctalopin. (469 aa)
atp1b2bSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (292 aa)
atp6v0d1V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) p [...] (350 aa)
atoh7Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. (134 aa)
nbeaaNeurobeachin a. (2998 aa)
nsfaN-ethylmaleimide-sensitive factor a. (744 aa)
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
cnnm2bCyclin and CBS domain divalent metal cation transport mediator 2b. (807 aa)
piguPhosphatidylinositol glycan anchor biosynthesis, class U. (435 aa)
get1Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. (170 aa)
akap12bA kinase (PRKA) anchor protein 12b. (1533 aa)
col6a1Collagen, type VI, alpha 1. (1007 aa)
cfap298Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity ; Belongs to the CFAP298 family. (290 aa)
bbs4Bardet-Biedl syndrome 4. (528 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
adcy1bAdenylate cyclase 1b; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (834 aa)
tmieTransmembrane inner ear. (231 aa)
pax5Paired box 5. (396 aa)
pkd2l1Polycystic kidney disease 2-like 1. (790 aa)
synj1Synaptojanin 1. (1308 aa)
ifng1Interferon gamma 1. (179 aa)
slc26a2Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (699 aa)
grhl1Grainyhead-like transcription factor 1. (613 aa)
grhl2bGrainyhead-like transcription factor 2b. (601 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa)
mtm1Myotubularin 1. (639 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (638 aa)
lamb1aLaminin, beta 1a. (1785 aa)
cacna1abCalcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b. (2319 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
arnt2Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor. (737 aa)
clrn1Clrn1 protein. (232 aa)
tomtTransmembrane O-methyltransferase homolog; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity. (259 aa)
denrDensity-regulated protein; May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). (208 aa)
cntn2Contactin 2. (1040 aa)
robo3Roundabout, axon guidance receptor, homolog 3 (Drosophila). (1420 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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