STRINGSTRING
prdm1a prdm1a pnn pnn aqp3a aqp3a trim33 trim33 slc24a5 slc24a5 tspan36 tspan36 tyrp1a tyrp1a vps11 vps11 sulf1 sulf1 mitfa mitfa shoc2 shoc2 ltk ltk bace2 bace2 srm srm jam3b jam3b duox duox gja5b gja5b meox1 meox1 kita kita asip1 asip1 adgra2 adgra2 bnc2 bnc2 erbb3b erbb3b alkal2a alkal2a ednrba ednrba mpv17 mpv17 col1a2 col1a2 kcnj13 kcnj13 ubxn4 ubxn4 sox5 sox5 pcdh10a pcdh10a csf1ra csf1ra igsf11 igsf11 tjp1a tjp1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
pnnPinin, desmosome-associated protein. (667 aa)
aqp3aAqp3 protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (296 aa)
trim33E3 ubiquitin-protein ligase TRIM33; May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells. (1176 aa)
slc24a5Sodium/potassium/calcium exchanger 5; Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (513 aa)
tspan36Tetraspanin-36; Plays a role in migration and segregation of pigment cells (melanophores and xanthophores). Contributes to pigment stripe patterning in the epidermis; Belongs to the tetraspanin (TM4SF) family. (243 aa)
tyrp1aTyrosinase-related protein 1a. (524 aa)
vps11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa)
sulf1Sulfatase FP1c. (1099 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
shoc2Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and stimulate raf1 activity at specialized signaling complexes (By similarity). (561 aa)
ltkTyrosine-protein kinase receptor. (1530 aa)
bace2Zgc:103530 protein; Belongs to the peptidase A1 family. (372 aa)
srmSpermidine synthase; Belongs to the spermidine/spermine synthase family. (289 aa)
jam3bJunctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. (333 aa)
duoxDual oxidase. (1519 aa)
gja5bGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (370 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
asip1Agouti-signaling protein 1. (125 aa)
adgra2Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] (1367 aa)
bnc2Basonuclin-2. (1171 aa)
erbb3bErb-b2 receptor tyrosine kinase 3b. (1429 aa)
alkal2aALK and LTK ligand 2a. (169 aa)
ednrbaEndothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (426 aa)
mpv17Protein Mpv17; Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity). Belongs to the peroxisomal membrane protein PXMP2/4 family. (177 aa)
col1a2Collagen, type I, alpha 2. (1352 aa)
kcnj13Potassium inwardly rectifying channel subfamily J member 13. (362 aa)
ubxn4UBX domain protein 4. (126 aa)
sox5SRY-box transcription factor 5. (759 aa)
pcdh10aProtocadherin 10a. (1001 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
igsf11Immunoglobulin superfamily member 11. (442 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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