STRINGSTRING
tbx16 tbx16 jag2b jag2b smo smo pink1 pink1 neflb neflb pmm2 pmm2 gdf3 gdf3 olig2 olig2 fzd8a fzd8a cdk5 cdk5 ihhb ihhb psenen psenen auts2a auts2a slc33a1 slc33a1 loxa loxa htr1ab htr1ab otpa otpa pitpnaa pitpnaa als2b als2b mib1 mib1 agrn agrn ap1g2 ap1g2 gabra1 gabra1 drd4a drd4a ap1g1 ap1g1 prmt8b prmt8b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbx16T-box transcription factor 16. (470 aa)
jag2bDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1254 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
pink1PTEN-induced kinase 1. (574 aa)
neflbNeurofilament, light polypeptide b; Belongs to the intermediate filament family. (579 aa)
pmm2Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (250 aa)
gdf3Protein DVR-1; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. (355 aa)
olig2Oligodendrocyte lineage transcription factor 2. (273 aa)
fzd8aFrizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
psenenGamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa)
auts2aActivator of transcription and developmental regulator AUTS2 a. (1278 aa)
slc33a1Solute carrier family 33 member 1. (541 aa)
loxaLysyl oxidase a. (408 aa)
htr1ab5-hydroxytryptamine (serotonin) receptor 1A b. (413 aa)
otpaOrthopedia homeobox a. (332 aa)
pitpnaaPhosphatidylinositol transfer protein, alpha a. (271 aa)
als2bAlsin Rho guanine nucleotide exchange factor ALS2 b. (1681 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
agrnAgrin. (1926 aa)
ap1g2AP-1 complex subunit gamma. (794 aa)
gabra1Gamma-aminobutyric acid (GABA) A receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (459 aa)
drd4aDopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ap1g1AP-1 complex subunit gamma. (819 aa)
prmt8bProtein arginine N-methyltransferase 8-B; S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily. (420 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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