STRINGSTRING
prdm1a prdm1a prps1a prps1a chm chm trim33 trim33 vps11 vps11 mitfa mitfa arl6ip1 arl6ip1 ltk ltk sox9b sox9b gpatch3 gpatch3 vps18 vps18 alkal1 alkal1 sox10 sox10 bnc2 bnc2 foxd3 foxd3 alkal2a alkal2a ednrba ednrba tyr tyr mpv17 mpv17 edn3b edn3b oca2 oca2 cpsf1 cpsf1 rab18b rab18b ece2b ece2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
prps1aPhosphoribosyl pyrophosphate synthetase 1A. (320 aa)
chmRab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa)
trim33E3 ubiquitin-protein ligase TRIM33; May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells. (1176 aa)
vps11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
arl6ip1ADP-ribosylation factor-like 6-interacting protein 1. (203 aa)
ltkTyrosine-protein kinase receptor. (1530 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
gpatch3G patch domain-containing 3. (669 aa)
vps18Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). May be involved in vesicle trafficking to the hepatocyte apical membrane and p [...] (974 aa)
alkal1ALK and LTK ligand 1. (170 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
bnc2Basonuclin-2. (1171 aa)
foxd3Forkhead box D3. (371 aa)
alkal2aALK and LTK ligand 2a. (169 aa)
ednrbaEndothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (426 aa)
tyrTyrosinase. (535 aa)
mpv17Protein Mpv17; Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity). Belongs to the peroxisomal membrane protein PXMP2/4 family. (177 aa)
edn3bEndothelin 3b. (153 aa)
oca2Oculocutaneous albinism II. (809 aa)
cpsf1Cleavage and polyadenylation-specific factor 1. (1451 aa)
rab18bRas-related protein Rab-18-B; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration; Belongs to the small GTPase superfamily. Rab family. (205 aa)
ece2bEndothelin-converting enzyme 2b. (765 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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