STRINGSTRING
cnpy1 cnpy1 fgf8a fgf8a tspan7 tspan7 itgav itgav chrd chrd enpp2 enpp2 fermt2 fermt2 znf703 znf703 dnmt3bb.1 dnmt3bb.1 prickle1a prickle1a cxcr4b cxcr4b foxh1 foxh1 cxcr4a cxcr4a sdc2 sdc2 fibpb fibpb fgf2 fgf2 ier2a ier2a itgb1b itgb1b tspan4a tspan4a eomesa eomesa lpar3 lpar3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cnpy1Protein canopy-1; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development. (187 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
tspan7Tetraspanin. (251 aa)
itgavIntegrin, alpha V; Belongs to the integrin alpha chain family. (1045 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
enpp2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (850 aa)
fermt2Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and ce [...] (684 aa)
znf703Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Required for segmental gene expression during hindbrain development. May regulate cell adhesion, migration and proliferation. (589 aa)
dnmt3bb.1DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (816 aa)
prickle1aPrickle homolog 1a. (793 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
foxh1Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
cxcr4aChemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family. (360 aa)
sdc2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (208 aa)
fibpbEGF-containing fibulin extracellular matrix protein 2b. (440 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
ier2aImmediate early response gene 2 protein; DNA-binding protein that seems to act as a transcription factor (By similarity). Mediates with FIBPB FGF-signaling in Kupffer's vesicle ciliogenesis and in the establishment of laterality in the embryo ; Belongs to the IER family. (180 aa)
itgb1bIntegrin beta; Belongs to the integrin beta chain family. (521 aa)
tspan4aTetraspanin. (239 aa)
eomesaT-box transcription factor eomesodermin. (661 aa)
lpar3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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