STRINGSTRING
smo smo fgf8a fgf8a ptch1 ptch1 pax8 pax8 sparc sparc s1pr2 s1pr2 crbn crbn hhip hhip atp1b2b atp1b2b hmx3a hmx3a sox10 sox10 rerea rerea ahi1 ahi1 eya4 eya4 cul4a cul4a fgf3 fgf3 foxi1 foxi1 slc12a2 slc12a2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
ptch1Protein patched homolog 1. (1475 aa)
pax8Paired box 8. (448 aa)
sparcSecreted protein, acidic, cysteine-rich (osteonectin). (291 aa)
s1pr2Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa)
crbnProtein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (446 aa)
hhipHedgehog-interacting protein. (693 aa)
atp1b2bSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (292 aa)
hmx3aHomeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (297 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
rereaArginine-glutamic acid dipeptide (RE) repeats a. (1531 aa)
ahi1Abelson helper integration site 1. (1193 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (638 aa)
cul4aCullin 4A; Belongs to the cullin family. (635 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
foxi1Forkhead box I1. (377 aa)
slc12a2Solute carrier family 12 member 2. (1136 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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