STRINGSTRING
rbm7 rbm7 cnr1 cnr1 olfm1a olfm1a gli2a gli2a robo2 robo2 isl1 isl1 pink1 pink1 tbx6 tbx6 gli2b gli2b smn1 smn1 sfpq sfpq spast spast rtn4r rtn4r ntn1b ntn1b myf6 myf6 chodl chodl ccsapb ccsapb dpysl3 dpysl3 kctd13 kctd13 aldh1a2 aldh1a2 pgk1 pgk1 coro1a coro1a neurog1 neurog1 rtn4a rtn4a gars1 gars1 col6a2 col6a2 kifbp kifbp adam19b adam19b exosc8 exosc8 sema3d sema3d alcamb alcamb ppp4ca ppp4ca mapk3 mapk3 ttn.2 ttn.2 ascc1 ascc1 col6a4a col6a4a slc33a1 slc33a1 mecp2 mecp2 appb appb chp1 chp1 zfyve27 zfyve27 chd7 chd7 depdc5 depdc5 vwc2 vwc2 ppp1r12a ppp1r12a dpysl2b dpysl2b pitpnaa pitpnaa tpp1 tpp1 tlcd3ba tlcd3ba ncam1a ncam1a washc5 washc5 ntn1a ntn1a lama1 lama1 scn1bb scn1bb hsd17b4 hsd17b4 srrm4 srrm4 trip4 trip4 glrx2 glrx2 exosc3 exosc3 kif22 kif22 kif5aa kif5aa tenm4 tenm4 dagla dagla cntn2 cntn2 dusp26 dusp26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
rbm7RNA-binding protein 7; RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre- mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). (252 aa)
cnr1Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (475 aa)
olfm1aOlfactomedin 1a. (485 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
robo2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (1387 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
pink1PTEN-induced kinase 1. (574 aa)
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
gli2bGLI family zinc finger 2b. (1225 aa)
smn1Survival motor neuron protein 1; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites. (281 aa)
sfpqSplicing factor proline/glutamine-rich. (638 aa)
spastSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (570 aa)
rtn4rReticulon 4 receptor. (479 aa)
ntn1bNetrin 1b. (602 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
chodlChondrolectin; Plays a role in the development of the nervous system such as in neurite outgrowth and elongation. Involved in motor axon growth and guidance. Required for correct interactions of motor axons with the horizontal myoseptum. (296 aa)
ccsapbCentriole, cilia and spindle-associated protein; Plays a role in embryonic development, including proper left- right asymmetry formation. Also required for proper cilia beating. Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (By similarity). (263 aa)
dpysl3Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. (567 aa)
kctd13BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (By similarity). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission. (330 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
pgk1Phosphoglycerate kinase. (417 aa)
coro1aCoronin; Belongs to the WD repeat coronin family. (455 aa)
neurog1Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificati [...] (208 aa)
rtn4aReticulon. (322 aa)
gars1Glycyl-tRNA synthetase. (690 aa)
col6a2Collagen, type VI, alpha 2. (1015 aa)
kifbpKIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. (631 aa)
adam19bADAM metallopeptidase domain 19b. (923 aa)
exosc8Exosome component 8. (277 aa)
sema3dSemaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa)
alcambActivated leukocyte cell adhesion molecule b. (562 aa)
ppp4caSerine/threonine-protein phosphatase 4 catalytic subunit A; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes; Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. (311 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
ttn.2Titin, tandem duplicate 2. (26265 aa)
ascc1Activating signal cointegrator 1 complex subunit 1. (249 aa)
col6a4aCollagen, type VI, alpha 4a. (2543 aa)
slc33a1Solute carrier family 33 member 1. (541 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
appbAmyloid beta (A4) precursor protein b. (694 aa)
chp1Calcineurin-like EF-hand protein 1. (194 aa)
zfyve27Zinc finger, FYVE domain-containing 27. (409 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
depdc5DEP domain-containing 5, GATOR1 subcomplex subunit. (1568 aa)
vwc2Von Willebrand factor C domain-containing 2. (309 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
dpysl2bDihydropyrimidinase-like 2b. (536 aa)
pitpnaaPhosphatidylinositol transfer protein, alpha a. (271 aa)
tpp1Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity). (582 aa)
tlcd3baTLC domain-containing 3Ba. (292 aa)
ncam1aNeural cell adhesion molecule 1a. (898 aa)
washc5WASH complex subunit 5; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. Belongs to the strumpellin family. (1021 aa)
ntn1aNetrin-1a. (603 aa)
lama1Laminin, alpha 1. (3075 aa)
scn1bbSodium channel, voltage-gated, type I, beta b. (204 aa)
hsd17b417-beta-hydroxysteroid dehydrogenase type 4. (725 aa)
srrm4Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2 (By similarity). (574 aa)
trip4Thyroid hormone receptor interactor 4. (564 aa)
glrx2Glutaredoxin 2. (170 aa)
exosc3Exosome component 3. (247 aa)
kif22Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. (634 aa)
kif5aaKinesin family member 5A, a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1033 aa)
tenm4Teneurin-4; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May play a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation of oligodendrocytes and myelination of axons. May function as a cellular signal transducer (By similarity). Belongs to the tenascin family. Teneurin subfamily. (2865 aa)
daglaDiacylglycerol lipase, alpha. (1076 aa)
cntn2Contactin 2. (1040 aa)
dusp26Uncharacterized protein. (594 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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