STRINGSTRING
slc40a1 slc40a1 tbx16 tbx16 col1a1a col1a1a acvr1l acvr1l hmcn1 hmcn1 gpc4 gpc4 bmpr1aa bmpr1aa dag1 dag1 chrd chrd tob1a tob1a atp6v1e1b atp6v1e1b fcho2 fcho2 smad5 smad5 tll1 tll1 nphp1 nphp1 bmp4 bmp4 fzd2 fzd2 plod1a plod1a hhip hhip frem1a frem1a zmynd11 zmynd11 itga3b itga3b smad4a smad4a piezo1 piezo1 frem2a frem2a iqck iqck bmp2b bmp2b max max clint1a clint1a piwil2 piwil2 perp perp mtm1 mtm1 clocka clocka fcho1 fcho1 sufu sufu szl szl ap1g2 ap1g2 cep55l cep55l fras1 fras1 apela apela myo5b myo5b col22a1 col22a1 apc apc col2a1b col2a1b ap1g1 ap1g1 acd acd zdhhc13 zdhhc13 mgaa mgaa bmp1a bmp1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
slc40a1Solute carrier family 40 member 1; May be involved in iron export and also in transfer of iron between maternal and fetal circulation. (562 aa)
tbx16T-box transcription factor 16. (470 aa)
col1a1aCollagen, type I, alpha 1a. (1447 aa)
acvr1lReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
hmcn1Hemicentin 1. (5616 aa)
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
bmpr1aaReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
dag1Dystroglycan 1. (866 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
tob1aTransducer of ERBB2, 1a. (322 aa)
atp6v1e1bATPase H+-transporting V1 subunit E1b. (226 aa)
fcho2F-BAR domain only protein 2; May function in an early step of clathrin-mediated endocytosis. (848 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
tll1Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. (1022 aa)
nphp1Nephronophthisis 1. (667 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
plod1aProcollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a. (730 aa)
hhipHedgehog-interacting protein. (693 aa)
frem1aFras1-related extracellular matrix 1a. (2167 aa)
zmynd11Zinc finger, MYND-type-containing 11. (640 aa)
itga3bIntegrin, alpha 3b; Belongs to the integrin alpha chain family. (1041 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
piezo1Piezo-type mechanosensitive ion channel component. (2436 aa)
frem2aFras1-like extracellular matrix protein 2a. (3119 aa)
iqckSimilar to IQ motif containing K. (225 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
maxProtein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity). (160 aa)
clint1aClathrin interactor 1a. (633 aa)
piwil2Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in germ cell differentiation and meiosis, independently of the function in transposable elements repression. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosyn [...] (1087 aa)
perpP53 apoptosis effector-related to pmp22. (185 aa)
mtm1Myotubularin 1. (639 aa)
clockaClock circadian regulator a. (892 aa)
fcho1F-BAR domain only protein 1. (1144 aa)
sufuSuppressor of fused homolog. (485 aa)
szlSzl protein. (282 aa)
ap1g2AP-1 complex subunit gamma. (794 aa)
cep55lCentrosomal protein of 55 kDa; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation (By similarity). Plays a role in the development of the brain and kidney. (435 aa)
fras1Fraser extracellular matrix complex subunit 1. (4003 aa)
apelaApelin receptor early endogenous ligand; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast m [...] (58 aa)
myo5bMyosin VB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1839 aa)
col22a1Collagen, type XXII, alpha 1. (1622 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
col2a1bCollagen, type II, alpha 1b. (1344 aa)
ap1g1AP-1 complex subunit gamma. (819 aa)
acdACD shelterin complex subunit and telomerase recruitment factor. (469 aa)
zdhhc13Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (645 aa)
mgaaMAX dimerization protein MGA a. (2838 aa)
bmp1aMetalloendopeptidase. (986 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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