STRINGSTRING
aqp3a aqp3a tspan36 tspan36 ltk ltk bace2 bace2 srm srm gja5b gja5b kita kita adgra2 adgra2 erbb3b erbb3b alkal2a alkal2a mpv17 mpv17 kcnj13 kcnj13 csf1ra csf1ra igsf11 igsf11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aqp3aAqp3 protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (296 aa)
tspan36Tetraspanin-36; Plays a role in migration and segregation of pigment cells (melanophores and xanthophores). Contributes to pigment stripe patterning in the epidermis; Belongs to the tetraspanin (TM4SF) family. (243 aa)
ltkTyrosine-protein kinase receptor. (1530 aa)
bace2Zgc:103530 protein; Belongs to the peptidase A1 family. (372 aa)
srmSpermidine synthase; Belongs to the spermidine/spermine synthase family. (289 aa)
gja5bGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (370 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
adgra2Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] (1367 aa)
erbb3bErb-b2 receptor tyrosine kinase 3b. (1429 aa)
alkal2aALK and LTK ligand 2a. (169 aa)
mpv17Protein Mpv17; Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity). Belongs to the peroxisomal membrane protein PXMP2/4 family. (177 aa)
kcnj13Potassium inwardly rectifying channel subfamily J member 13. (362 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
igsf11Immunoglobulin superfamily member 11. (442 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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