node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ccbe1 | flt4 | ENSDARP00000106577 | ENSDARP00000133227 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.868 |
ccbe1 | prox1a | ENSDARP00000106577 | ENSDARP00000071943 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Prospero homeobox 1a. | 0.745 |
ccbe1 | svep1 | ENSDARP00000106577 | ENSDARP00000142845 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1. | 0.442 |
ccbe1 | vegfc | ENSDARP00000106577 | ENSDARP00000092263 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.960 |
dcc | ntn1a | ENSDARP00000137236 | ENSDARP00000133934 | DCC netrin 1 receptor. | Netrin-1a. | 0.748 |
flt4 | ccbe1 | ENSDARP00000133227 | ENSDARP00000106577 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | 0.868 |
flt4 | npas4l | ENSDARP00000133227 | ENSDARP00000151859 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Neuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. | 0.414 |
flt4 | prox1a | ENSDARP00000133227 | ENSDARP00000071943 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Prospero homeobox 1a. | 0.832 |
flt4 | vegfc | ENSDARP00000133227 | ENSDARP00000092263 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.999 |
npas4l | flt4 | ENSDARP00000151859 | ENSDARP00000133227 | Neuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.414 |
ntn1a | dcc | ENSDARP00000133934 | ENSDARP00000137236 | Netrin-1a. | DCC netrin 1 receptor. | 0.748 |
prox1a | ccbe1 | ENSDARP00000071943 | ENSDARP00000106577 | Prospero homeobox 1a. | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | 0.745 |
prox1a | flt4 | ENSDARP00000071943 | ENSDARP00000133227 | Prospero homeobox 1a. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.832 |
prox1a | vegfc | ENSDARP00000071943 | ENSDARP00000092263 | Prospero homeobox 1a. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.849 |
svep1 | ccbe1 | ENSDARP00000142845 | ENSDARP00000106577 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1. | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | 0.442 |
vegfc | ccbe1 | ENSDARP00000092263 | ENSDARP00000106577 | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | 0.960 |
vegfc | flt4 | ENSDARP00000092263 | ENSDARP00000133227 | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.999 |
vegfc | prox1a | ENSDARP00000092263 | ENSDARP00000071943 | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | Prospero homeobox 1a. | 0.849 |