STRINGSTRING
syk syk zap70 zap70 prox1a prox1a vegfc vegfc prox3 prox3 ccbe1 ccbe1 elmo1 elmo1 flt4 flt4 ntn1a ntn1a dcc dcc lpar1 lpar1 svep1 svep1 npas4l npas4l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sykTyrosine-protein kinase. (608 aa)
zap70Tyrosine-protein kinase. (604 aa)
prox1aProspero homeobox 1a. (739 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
prox3Prospero-like protein Prox1b. (659 aa)
ccbe1Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. (401 aa)
elmo1Engulfment and Cell motility 1 (Ced-12 homolog, C. elegans). (726 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
ntn1aNetrin-1a. (603 aa)
dccDCC netrin 1 receptor. (1200 aa)
lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (280 aa)
svep1Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1. (3615 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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