STRINGSTRING
pdhb pdhb rnf2 rnf2 ednraa ednraa noc3l noc3l prdm1a prdm1a rad21a rad21a psen2 psen2 ric8b ric8b mylipa mylipa smo smo atp6v0ca atp6v0ca aqp3a aqp3a rb1 rb1 noto noto poc1b poc1b slc24a5 slc24a5 tspan36 tspan36 pax3a pax3a slc45a2 slc45a2 pigk pigk atp6v1e1b atp6v1e1b tyrp1a tyrp1a hdac1 hdac1 hoxa13b hoxa13b vps11 vps11 nr3c1 nr3c1 scube2 scube2 mitfa mitfa dharma dharma hsd3b1 hsd3b1 ltk ltk gnat2 gnat2 sox9b sox9b bace2 bace2 atp6v1f atp6v1f htt htt gdf6a gdf6a atp1a1a.1 atp1a1a.1 ptpn11a ptpn11a lmln lmln atp6v0d1 atp6v0d1 gja5b gja5b atoh7 atoh7 nsfa nsfa hps5 hps5 meox1 meox1 itga3b itga3b ocrl ocrl kita kita vps39 vps39 kitlga kitlga erbb3b erbb3b eif3ea eif3ea fto fto foxd3 foxd3 pmela pmela atp6ap1b atp6ap1b ednrba ednrba pknox1.1 pknox1.1 tyr tyr atp6v1h atp6v1h chd7 chd7 mpv17 mpv17 edn3b edn3b snap29 snap29 med23 med23 scn1lab scn1lab kcnj13 kcnj13 mmp17b mmp17b mib1 mib1 szl szl slc12a2 slc12a2 ece2b ece2b hoxa13a hoxa13a psen1 psen1 dync1h1 dync1h1 kif5aa kif5aa capzb capzb smarca4a smarca4a ptpn21 ptpn21 pcdh10a pcdh10a trpm7 trpm7 csf1ra csf1ra denr denr dhrsx dhrsx med14 med14 igsf11 igsf11 tjp1a tjp1a tfap2a tfap2a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdhbPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
rnf2E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa)
ednraaEndothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (422 aa)
noc3lNucleolar complex protein 3 homolog; Belongs to the CBF/MAK21 family. (800 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
rad21aDouble-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...] (643 aa)
psen2Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. (441 aa)
ric8bSynembryn-B; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. (536 aa)
mylipaE3 ubiquitin-protein ligase MYLIP-A; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway. (472 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
atp6v0caV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
aqp3aAqp3 protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (296 aa)
rb1Retinoblastoma 1. (903 aa)
notoNotochord homeobox. (241 aa)
poc1bPOC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. (490 aa)
slc24a5Sodium/potassium/calcium exchanger 5; Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (513 aa)
tspan36Tetraspanin-36; Plays a role in migration and segregation of pigment cells (melanophores and xanthophores). Contributes to pigment stripe patterning in the epidermis; Belongs to the tetraspanin (TM4SF) family. (243 aa)
pax3aTranscription factor PAX3. (509 aa)
slc45a2Solute carrier family 45 member 2. (554 aa)
pigkGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (389 aa)
atp6v1e1bATPase H+-transporting V1 subunit E1b. (226 aa)
tyrp1aTyrosinase-related protein 1a. (524 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
hoxa13bHomeobox protein Hox-A13b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (289 aa)
vps11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa)
nr3c1Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa)
scube2Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
dharmaDharma. (192 aa)
hsd3b1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (374 aa)
ltkTyrosine-protein kinase receptor. (1530 aa)
gnat2Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 2. (354 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
bace2Zgc:103530 protein; Belongs to the peptidase A1 family. (372 aa)
atp6v1fV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
httHuntingtin. (3121 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
atp1a1a.1Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
lmlnLeishmanolysin-like peptidase. (664 aa)
atp6v0d1V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) p [...] (350 aa)
gja5bGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (370 aa)
atoh7Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. (134 aa)
nsfaN-ethylmaleimide-sensitive factor a. (744 aa)
hps5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1133 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
itga3bIntegrin, alpha 3b; Belongs to the integrin alpha chain family. (1041 aa)
ocrlOCRL inositol polyphosphate-5-phosphatase. (953 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
vps39VPS39 subunit of HOPS complex. (875 aa)
kitlgaKit ligand a. (272 aa)
erbb3bErb-b2 receptor tyrosine kinase 3b. (1429 aa)
eif3eaEukaryotic translation initiation factor 3 subunit E-A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (446 aa)
ftoFTO alpha-ketoglutarate-dependent dioxygenase. (567 aa)
foxd3Forkhead box D3. (371 aa)
pmelaPremelanosome protein a. (825 aa)
atp6ap1bATPase H+-transporting accessory protein 1b. (459 aa)
ednrbaEndothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (426 aa)
pknox1.1Homeodomain transcription factor Prep1. (433 aa)
tyrTyrosinase. (535 aa)
atp6v1hV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (481 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
mpv17Protein Mpv17; Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity). Belongs to the peroxisomal membrane protein PXMP2/4 family. (177 aa)
edn3bEndothelin 3b. (153 aa)
snap29Synaptosome-associated protein 29. (232 aa)
med23Mediator of RNA polymerase II transcription subunit 23; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1387 aa)
scn1labSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1996 aa)
kcnj13Potassium inwardly rectifying channel subfamily J member 13. (362 aa)
mmp17bMatrix metallopeptidase 17b. (613 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
szlSzl protein. (282 aa)
slc12a2Solute carrier family 12 member 2. (1136 aa)
ece2bEndothelin-converting enzyme 2b. (765 aa)
hoxa13aHomeobox protein Hox-A13a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (310 aa)
psen1Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa)
dync1h1Dynein, cytoplasmic 1, heavy chain 1. (1765 aa)
kif5aaKinesin family member 5A, a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1033 aa)
capzbF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa)
smarca4aSWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4a. (1627 aa)
ptpn21Protein tyrosine phosphatase non-receptor type 21. (1204 aa)
pcdh10aProtocadherin 10a. (1001 aa)
trpm7Transient receptor potential cation channel, subfamily M, member 7. (1787 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
denrDensity-regulated protein; May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). (208 aa)
dhrsxDehydrogenase/reductase (SDR family) X-linked. (324 aa)
med14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1451 aa)
igsf11Immunoglobulin superfamily member 11. (442 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
tfap2aTranscription factor AP-2 alpha. (450 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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