STRINGSTRING
hoxb8a hoxb8a cxcl12a cxcl12a tgfb1a tgfb1a ackr3b ackr3b snai1b snai1b ext2 ext2 esr1 esr1 kremen1 kremen1 prpf4 prpf4 sema3d sema3d src src sh3pxd2aa sh3pxd2aa prnprs3 prnprs3 cdh4 cdh4 apc apc il17rd il17rd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hoxb8aHomeobox protein Hox-B8a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (245 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
ackr3bAtypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family. (362 aa)
snai1bSnail family zinc finger 1b. (256 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
kremen1Kringle-containing transmembrane protein 1. (465 aa)
prpf4PRP4 pre-mRNA-processing factor 4 homolog (yeast). (507 aa)
sema3dSemaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
sh3pxd2aaSH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation; Belongs to the SH3PXD2 family. (1085 aa)
prnprs3Prion protein,-related sequence 3. (559 aa)
cdh4Cadherin 4, type 1, R-cadherin (retinal); Cadherins are calcium-dependent cell adhesion proteins. (931 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
il17rdInterleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. (743 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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