STRINGSTRING
gbx2 gbx2 pnn pnn elavl3 elavl3 her2 her2 id1 id1 fgf16 fgf16 pax2a pax2a klf8 klf8 actr10 actr10 ocrl ocrl csrnp1b csrnp1b fgf22 fgf22 auts2a auts2a nlk2 nlk2 lrp5 lrp5 appb appb lef1 lef1 kmt2a kmt2a met met fgfr2 fgfr2 med12 med12 gldc gldc adgrg1 adgrg1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gbx2Gastrulation brain homeo box 2. (342 aa)
pnnPinin, desmosome-associated protein. (667 aa)
elavl3ELAV-like protein; Belongs to the RRM elav family. (359 aa)
her2Hairy-related 2. (108 aa)
id1Inhibitor of DNA-binding 1, HLH protein. (128 aa)
fgf16Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
klf8Kruppel-like factor 8. (343 aa)
actr10Actin-related protein 10; Belongs to the actin family. (415 aa)
ocrlOCRL inositol polyphosphate-5-phosphatase. (953 aa)
csrnp1bCysteine-serine-rich nuclear protein 1b. (566 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
auts2aActivator of transcription and developmental regulator AUTS2 a. (1278 aa)
nlk2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1615 aa)
appbAmyloid beta (A4) precursor protein b. (694 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4218 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
fgfr2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa)
med12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa)
gldcGlycine dehydrogenase (decarboxylating). (981 aa)
adgrg1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (648 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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