STRINGSTRING
ofd1 ofd1 csrp1a csrp1a acvr1l acvr1l cdh2 cdh2 prdm1a prdm1a gpc4 gpc4 ift81 ift81 bmp7a bmp7a rhoab rhoab aurka aurka churc1 churc1 mkks mkks ift74 ift74 vangl2 vangl2 ift88 ift88 kif7 kif7 tdgf1 tdgf1 arl6 arl6 smad5 smad5 sulf1 sulf1 bbs5 bbs5 prickle1a prickle1a afp4 afp4 bbs2 bbs2 rack1 rack1 foxd5 foxd5 nphp1 nphp1 scrib scrib bmp4 bmp4 fzd2 fzd2 ptenb ptenb ryk ryk bbs7 bbs7 dact2 dact2 nup210 nup210 arl13b arl13b zic3 zic3 mapk9 mapk9 map2k4b map2k4b bbs1 bbs1 bbs4 bbs4 bmp2b bmp2b foxd3 foxd3 pcdh18a pcdh18a appb appb ift140 ift140 diaph2 diaph2 lpp lpp tmem67 tmem67 ankrd6b ankrd6b ccdc28b ccdc28b bbs10 bbs10 disc1 disc1 inppl1a inppl1a fcho1 fcho1 pacsin3 pacsin3 wnt5b wnt5b mibp2 mibp2 ier2a ier2a cdh1 cdh1 neo1a neo1a ttc8 ttc8 zeb2a zeb2a bbs9 bbs9 dub dub bbs12 bbs12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ofd1Oral-facial-digital syndrome 1 protein homolog; Component of the centrioles controlling mother and daughter centrioles length. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis; Belongs to the OFD1 family. (902 aa)
csrp1aCysteine and glycine-rich protein 1a. (192 aa)
acvr1lReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
ift81Intraflagellar transport 81 homolog. (675 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
aurkaAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
churc1Protein Churchill; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement. Does not bind DNA by itself (By similarity). (112 aa)
mkksMcKusick-Kaufman syndrome. (563 aa)
ift74Intraflagellar transport 74. (583 aa)
vangl2Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
kif7Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
arl6ADP-ribosylation factor-like protein 6; Probably involved in membrane protein trafficking at the base of the ciliary organelle. May function in cilia biogenesis. Isoform 2 is required for proper retinal function and organization. Belongs to the small GTPase superfamily. Arf family. (186 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
sulf1Sulfatase FP1c. (1099 aa)
bbs5Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family. (342 aa)
prickle1aPrickle homolog 1a. (793 aa)
afp4Type IV antifreeze protein A. (130 aa)
bbs2Bardet-Biedl syndrome 2 protein homolog; Required for ciliogenesis. (715 aa)
rack1Guanine nucleotide-binding protein subunit beta-2-like 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (317 aa)
foxd5Forkhead box D5. (321 aa)
nphp1Nephronophthisis 1. (667 aa)
scribProtein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
rykReceptor-like tyrosine kinase. (604 aa)
bbs7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
dact2Dapper homolog 2; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Positive regulator of the Wnt signaling pathway which acts downstream of wnt1 indicative for non- canonical Wnt signaling. Also negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. Required for convergent extension movements in gastrulation. (837 aa)
nup210Nucleoporin 210. (1873 aa)
arl13bADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa)
zic3ZIC family member 3 heterotaxy 1 (Odd-paired homolog, Drosophila). (448 aa)
mapk9Mitogen-activated protein kinase. (421 aa)
map2k4bMitogen-activated protein kinase kinase 4B; Belongs to the protein kinase superfamily. (417 aa)
bbs1Bardet-Biedl syndrome 1. (588 aa)
bbs4Bardet-Biedl syndrome 4. (528 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
foxd3Forkhead box D3. (371 aa)
pcdh18aProtocadherin 18a. (1135 aa)
appbAmyloid beta (A4) precursor protein b. (694 aa)
ift140Intraflagellar transport 140 homolog (Chlamydomonas). (1445 aa)
diaph2Diaphanous-related formin 2. (1077 aa)
lppLIM domain-containing preferred translocation partner in lipoma. (556 aa)
tmem67Transmembrane protein 67. (982 aa)
ankrd6bAnkyrin repeat domain 6b. (728 aa)
ccdc28bCoiled-coil domain-containing 28B. (213 aa)
bbs10Bardet-Biedl syndrome 10. (151 aa)
disc1DISC1 scaffold protein. (994 aa)
inppl1aPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of [...] (1003 aa)
fcho1F-BAR domain only protein 1. (1144 aa)
pacsin3Protein kinase C and casein kinase substrate in neurons 3. (377 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
mibp2Muscle-specific beta 1 integrin-binding protein 2. (203 aa)
ier2aImmediate early response gene 2 protein; DNA-binding protein that seems to act as a transcription factor (By similarity). Mediates with FIBPB FGF-signaling in Kupffer's vesicle ciliogenesis and in the establishment of laterality in the embryo ; Belongs to the IER family. (180 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
neo1aNeogenin 1a. (1428 aa)
ttc8Tetratricopeptide repeat domain 8. (268 aa)
zeb2aZinc finger E-box-binding homeobox 2a. (1242 aa)
bbs9Bardet-Biedl syndrome 9. (842 aa)
dubDuboraya. (305 aa)
bbs12Bardet-Biedl syndrome 12. (763 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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