STRINGSTRING
hoxb8a hoxb8a cxcl12a cxcl12a cxcr4b cxcr4b ext2 ext2 kremen1 kremen1 src src sh3pxd2aa sh3pxd2aa prnprs3 prnprs3 apc apc il17rd il17rd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hoxb8aHomeobox protein Hox-B8a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (245 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
kremen1Kringle-containing transmembrane protein 1. (465 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
sh3pxd2aaSH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation; Belongs to the SH3PXD2 family. (1085 aa)
prnprs3Prion protein,-related sequence 3. (559 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
il17rdInterleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. (743 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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