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pdhb pdhb traf3ip1 traf3ip1 cyp20a1 cyp20a1 lamc1 lamc1 crx crx glra1 glra1 cnr2 cnr2 rlbp1b rlbp1b gdf6a gdf6a lmx1bb lmx1bb cplx4a cplx4a grk7a grk7a vhl vhl prim1 prim1 get1 get1 napbb napbb mfrp mfrp gucy2d gucy2d celsr3 celsr3 epb41l5 epb41l5 pcdh19 pcdh19 per2 per2 rlbp1a rlbp1a grk1b grk1b lamb1a lamb1a atp6v0e1 atp6v0e1 pde6c pde6c kif5aa kif5aa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdhbPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
traf3ip1TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). (629 aa)
cyp20a1Cytochrome P450, family 20, subfamily A, polypeptide 1. (463 aa)
lamc1Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa)
crxCone-rod homeobox. (281 aa)
glra1Glycine receptor subunit alphaZ1; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity); Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily. (459 aa)
cnr2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (383 aa)
rlbp1bCellular retinaldehyde-binding protein b. (307 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
lmx1bbLIM homeobox transcription factor 1, beta 1. (375 aa)
cplx4aSi:ch211-233a1.5. (159 aa)
grk7aRhodopsin kinase grk7a; Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (549 aa)
vhlVon Hippel-Lindau tumor suppressor. (175 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (425 aa)
get1Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. (170 aa)
napbbN-ethylmaleimide-sensitive factor attachment protein, beta b. (295 aa)
mfrpMembrane frizzled-related protein. (572 aa)
gucy2dGuanylate cyclase. (1176 aa)
celsr3Cadherin, EGF LAG seven-pass G-type receptor 3. (2065 aa)
epb41l5Erythrocyte membrane protein band 4.1-like 5. (461 aa)
pcdh19Protocadherin 19. (1088 aa)
per2Period circadian clock 2. (1399 aa)
rlbp1aRetinaldehyde-binding protein 1a. (312 aa)
grk1bG protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (559 aa)
lamb1aLaminin, beta 1a. (1785 aa)
atp6v0e1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
pde6cPhosphodiesterase. (852 aa)
kif5aaKinesin family member 5A, a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1033 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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