(15 nodes) Retina increased amount, abnormal network (Danio rerio)

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	thraa	Thyroid hormone receptor alpha-A; High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (427 aa)
	hif1ab	Hypoxia-inducible factor 1 subunit alpha b. (777 aa)
	vsx2	Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. (372 aa)
	rbbp4	Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (424 aa)
	hdac1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
	gdf6a	Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
	id2a	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a. (137 aa)
	tgif1	TGFB-induced factor homeobox 1. (273 aa)
	LOC568792	ADAM metallopeptidase with thrombospondin type 1 motif, 16. (1224 aa)
	prom1b	Prominin 1 b. (853 aa)
	kcnj13	Potassium inwardly rectifying channel subfamily J member 13. (362 aa)
	ehmt2	Euchromatic histone-lysine N-methyltransferase 2. (1167 aa)
	znf644b	Zinc finger protein 644b. (1267 aa)
	mib1	E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
	lbhl	LBH domain-containing protein. (182 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ehmt2	hdac1	ENSDARP00000130049	ENSDARP00000051798	Euchromatic histone-lysine N-methyltransferase 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.969
ehmt2	rbbp4	ENSDARP00000130049	ENSDARP00000048143	Euchromatic histone-lysine N-methyltransferase 2.	Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.	0.739
ehmt2	znf644b	ENSDARP00000130049	ENSDARP00000130410	Euchromatic histone-lysine N-methyltransferase 2.	Zinc finger protein 644b.	0.478
hdac1	ehmt2	ENSDARP00000051798	ENSDARP00000130049	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Euchromatic histone-lysine N-methyltransferase 2.	0.969
hdac1	hif1ab	ENSDARP00000051798	ENSDARP00000004329	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Hypoxia-inducible factor 1 subunit alpha b.	0.451
hdac1	id2a	ENSDARP00000051798	ENSDARP00000072092	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a.	0.503
hdac1	rbbp4	ENSDARP00000051798	ENSDARP00000048143	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.	0.993
hdac1	tgif1	ENSDARP00000051798	ENSDARP00000076869	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	TGFB-induced factor homeobox 1.	0.688
hif1ab	hdac1	ENSDARP00000004329	ENSDARP00000051798	Hypoxia-inducible factor 1 subunit alpha b.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.451
id2a	hdac1	ENSDARP00000072092	ENSDARP00000051798	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.503
rbbp4	ehmt2	ENSDARP00000048143	ENSDARP00000130049	Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.	Euchromatic histone-lysine N-methyltransferase 2.	0.739
rbbp4	hdac1	ENSDARP00000048143	ENSDARP00000051798	Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.993
tgif1	hdac1	ENSDARP00000076869	ENSDARP00000051798	TGFB-induced factor homeobox 1.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.688
znf644b	ehmt2	ENSDARP00000130410	ENSDARP00000130049	Zinc finger protein 644b.	Euchromatic histone-lysine N-methyltransferase 2.	0.478

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