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| | thraa | Thyroid hormone receptor alpha-A; High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (427 aa) |
| | hey2 | Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. (324 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | atp1b1a | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | nkx2.7 | NK2 transcription factor-related 7. (269 aa) |
| | gbx2 | Gastrulation brain homeo box 2. (342 aa) |
| | lft1 | Left-right determination factor; Belongs to the TGF-beta family. (358 aa) |
| | irf4a | Interferon regulatory factor 4a. (460 aa) |
| | jag1b | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa) |
| | tbx4 | T-box transcription factor 4. (543 aa) |
| | efhc2 | EF-hand domain-containing family member C2. (748 aa) |
| | ube2ib | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | isl1 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa) |
| | tbx6 | T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa) |
| | amh | Anti-Mullerian hormone. (549 aa) |
| | nkx2.5 | NK2 homeobox 5. (314 aa) |
| | gfi1aa | Growth factor-independent 1A transcription repressor a. (385 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | snap25a | Synaptosomal-associated protein 25-A; May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion; Belongs to the SNAP-25 family. (204 aa) |
| | sfpq | Splicing factor proline/glutamine-rich. (638 aa) |
| | racgap1 | Rac GTPase-activating protein 1. (654 aa) |
| | rb1 | Retinoblastoma 1. (903 aa) |
| | ccm2 | Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). (455 aa) |
| | marcksb | Myristoylated alanine-rich protein kinase C substrate b. (227 aa) |
| | gata5 | Transcription factor gata5. (383 aa) |
| | pkd2 | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...] (904 aa) |
| | tbx2a | T-box transcription factor 2a. (686 aa) |
| | mycbp2 | E3 ubiquitin-protein ligase MYCBP2; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probabl [...] (4574 aa) |
| | lbx2 | Ladybird homeobox homolog 2 (Drosophila). (257 aa) |
| | tbx5a | T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa) |
| | sim1a | Single-minded homolog 1-A; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (745 aa) |
| | slco1c1 | Solute carrier organic anion transporter family member. (710 aa) |
| | kif7 | Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa) |
| | cyp26a1 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa) |
| | irx3b | Iroquois homeobox 3b. (343 aa) |
| | dicer1 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1865 aa) |
| | lnx2a | Ligand of numb-protein X 2a. (737 aa) |
| | ins | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | znf703 | Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Required for segmental gene expression during hindbrain development. May regulate cell adhesion, migration and proliferation. (589 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | dand5 | DAN domain family, member 5. (243 aa) |
| | cxcl12a | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | wnt9b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | th2 | Tyrosine hydroxylase 2. (471 aa) |
| | cep41 | Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of tubulin polyglutamylases between the basal body and the cilium. Belongs to the CEP41 family. (374 aa) |
| | cacnb1 | Calcium channel, voltage-dependent, beta 1 subunit. (603 aa) |
| | emx1 | Homeobox protein EMX1; May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system; Belongs to the EMX homeobox family. (231 aa) |
| | fosl2 | FOS-like 2, AP-1 transcription factor subunit. (341 aa) |
| | hsbp1b | Heat shock factor-binding protein 1b. (76 aa) |
| | lpar2b | Lysophosphatidic acid receptor 2b; Belongs to the G-protein coupled receptor 1 family. (369 aa) |
| | ccn2a | Novel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa) |
| | lft2 | Left-right determination factor. (362 aa) |
| | id4 | Inhibitor of DNA-binding 4. (126 aa) |
| | fzd8a | Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa) |
| | snai1b | Snail family zinc finger 1b. (256 aa) |
| | kcnj11 | Potassium inwardly-rectifying channel, subfamily J, member 11. (381 aa) |
| | kcng4b | Potassium voltage-gated channel, subfamily G, member 4b; Belongs to the potassium channel family. (535 aa) |
| | scrib | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa) |
| | rx3 | Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa) |
| | gdf6a | Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa) |
| | sox3 | Transcription factor Sox-3; Transcriptional activator. (300 aa) |
| | fbl | Fibrillarin. (317 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) |
| | ctsba | Cathepsin B, a; Belongs to the peptidase C1 family. (330 aa) |
| | id2a | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a. (137 aa) |
| | irf8 | Interferon regulatory factor 8. (423 aa) |
| | cybb | Cytochrome b-245, beta polypeptide (chronic granulomatous disease). (565 aa) |
| | fhl1b | Four and a half LIM domains 1b. (280 aa) |
| | cxcr4a | Chemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | snap25b | Synaptosomal-associated protein 25-B; May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion; Belongs to the SNAP-25 family. (203 aa) |
| | crb2a | Crumbs cell polarity complex component 2a. (1466 aa) |
| | cish | Cytokine inducible SH2-containing protein A. (212 aa) |
| | kdm1a | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (833 aa) |
| | ranbp9 | Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. (597 aa) |
| | vps45 | Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (568 aa) |
| | jam3b | Junctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. (333 aa) |
| | col15a1b | Collagen, type XV, alpha 1b. (1245 aa) |
| | amotl2a | Angiomotin-like 2a; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments and for cell movements during embryogenesis. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Belongs to the angiomotin family. (721 aa) |
| | slc8a1a | Solute carrier family 8 member 1a; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (969 aa) |
| | grip2a | Glutamate receptor-interacting protein 2a. (736 aa) |
| | prpf4 | PRP4 pre-mRNA-processing factor 4 homolog (yeast). (507 aa) |
| | ppargc1a | Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (859 aa) |
| | dld | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (717 aa) |
| | tcf7l1a | Transcription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa) |
| | ptger4a | Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (403 aa) |
| | afap1l2 | Actin filament-associated protein 1-like 2. (859 aa) |
| | dll4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (683 aa) |
| | vhl | Von Hippel-Lindau tumor suppressor. (175 aa) |
| | med10 | Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Negative [...] (134 aa) |
| | rcor1 | REST corepressor 1. (458 aa) |
| | eaf1 | ELL-associated factor 1. (253 aa) |
| | pbx4 | Pre-B-cell leukemia transcription factor 4. (343 aa) |
| | edn1 | Endothelin 1. (188 aa) |
| | smad4a | Mothers against decapentaplegic homolog. (547 aa) |
| | atxn7 | Ataxin 7. (866 aa) |
| | amer1 | APC membrane recruitment protein 1; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context (By similarity); Belongs to the Amer family. (953 aa) |
| | brca2 | BRCA2 DNA repair-associated. (2874 aa) |
| | ajuba | Ajuba LIM protein. (688 aa) |
| | vclb | Vinculin b. (987 aa) |
| | becn1 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa) |
| | nup214 | Nucleoporin 214. (1218 aa) |
| | prr7 | Proline-rich 7 (synaptic). (245 aa) |
| | ptgs1 | Prostaglandin-endoperoxide synthase 1. (597 aa) |
| | foxc1a | Forkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa) |
| | nr0b1 | Nuclear receptor subfamily 0, group B, member 1. (302 aa) |
| | bcl11ba | BAF chromatin-remodeling complex subunit BCL11B a. (208 aa) |
| | tbx5b | T-box transcription factor 5b. (430 aa) |
| | tbx2b | T-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa) |
| | insm1a | Insulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa) |
| | lrp5 | Low density lipoprotein receptor-related protein 5. (1615 aa) |
| | iqce | IQ motif-containing E. (680 aa) |
| | ptger2a | Prostaglandin E2 receptor subtype EP2-like; Belongs to the G-protein coupled receptor 1 family. (368 aa) |
| | fat1a | FAT atypical cadherin 1a. (4611 aa) |
| | tbx16l | T-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa) |
| | cdk5rap3 | CDK5 regulatory subunit-associated protein 3. (507 aa) |
| | fdx1b | Ferredoxin 1b. (168 aa) |
| | wnt8a | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa) |
| | lamc3 | Laminin, gamma 3. (1643 aa) |
| | myof | Myoferlin. (2030 aa) |
| | fam49a | Family with sequence similarity 49 member A. (324 aa) |
| | hnf1ba | Hepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa) |
| | scfd1 | Sec1 family domain-containing 1; Belongs to the STXBP/unc-18/SEC1 family. (632 aa) |
| | hoxb1b | Homeobox protein Hox-B1b; Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments; Belongs to the Antp homeobox family. Labial subfamily. (229 aa) |
| | otpa | Orthopedia homeobox a. (332 aa) |
| | epb41l5 | Erythrocyte membrane protein band 4.1-like 5. (461 aa) |
| | hwa | Protein huluwa; Key maternal determinant of the dorsal organizer and body axis formation in vertebrates that acts by promoting stabilization of beta-catenin (ctnnb1). Localizes on the plasma membrane of the future dorsal blastomeres in early blastulas and binds to and promotes the tankyrase-mediated degradation of axin (axin1 and axin2). Axin degradation results in stabilization and nuclear translocation of beta-catenin (ctnnb1) for activating organizer-specific target gene expression. Belongs to the huluwa family. (294 aa) |
| | hars | Histidine--tRNA ligase; Catalyzes the aminoacylation of histidyl-tRNA. Belongs to the class-II aminoacyl-tRNA synthetase family. (520 aa) |
| | epha4a | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa) |
| | atg5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
| | itgb2 | Integrin beta. (768 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | tnnt2a | Troponin T type 2a (cardiac). (282 aa) |
| | buc | Bucky ball; Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis. Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains. Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body. Interaction of BUC protein and mRNA with rbpms2 and d [...] (639 aa) |
| | nova2 | NOVA alternative-splicing regulator 2. (517 aa) |
| | ccdc136b | Coiled-coil domain-containing 136b. (358 aa) |
| | mespbb | Mesoderm posterior bb. (244 aa) |
| | meis3 | Myeloid ecotropic viral integration site 3. (415 aa) |
| | rgs2 | Regulator of G protein-signaling 2. (199 aa) |
| | ankrd55 | Ankyrin repeat domain 55. (650 aa) |
| | znf644a | Zinc finger protein 644a. (1169 aa) |
| | med24 | Mediator of RNA polymerase II transcription subunit 24; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (989 aa) |
| | hif1al | Hypoxia-inducible factor 1 subunit alpha,-like. (626 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | sufu | Suppressor of fused homolog. (485 aa) |
| | bmper | BMP-binding endothelial regulator. (667 aa) |
| | slc30a8 | Solute carrier family 30 member 8. (388 aa) |
| | vegfaa | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa) |
| | atg7 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (711 aa) |
| | uhrf1 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa) |
| | ide | Novel protein similar to H.sapiens IDE, insulin-degrading enzyme (IDE, zgc:162603); Belongs to the peptidase M16 family. (998 aa) |
| | cep128 | Centrosomal protein 128. (533 aa) |
| | rest | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa) |
| | hmgcs1 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa) |
| | sox5 | SRY-box transcription factor 5. (759 aa) |
| | irf2bp2b | Interferon regulatory factor 2-binding protein 2-B; Acts as a transcriptional repressor; Belongs to the IRF2BP family. (501 aa) |
| | tpbga | Trophoblast glycoprotein a. (372 aa) |
| | krit1 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa) |
| | kif5aa | Kinesin family member 5A, a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1033 aa) |
| | apc | APC regulator of WNT-signaling pathway. (2754 aa) |
| | PITPNC1 | Phosphatidylinositol transfer protein cytoplasmic 1. (261 aa) |
| | sprtn | SprT-like N-terminal domain. (636 aa) |
| | twsg1b | Twisted gastrulation protein homolog 1-B; Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd- independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization; Belongs to the twisted gastrulation protein family. (155 aa) |
| | fndc3a | Fibronectin type III domain-containing 3A. (1215 aa) |
| | pparg | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa) |
| | zdhhc13 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (645 aa) |
| | cyp21a2 | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (584 aa) |
| | npas4l | Neuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa) |
| | thrb | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. (508 aa) |
| | sox6 | SRY-box transcription factor 6. (816 aa) |
| | ripply1 | Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. (140 aa) |
| | fer | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (862 aa) |
