(32 nodes) Swim bladder inflation decreased occurrence, abnormal network (Danio rerio)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	wdr36	WD repeat domain 36. (896 aa)
	surf1	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family. (309 aa)
	chm	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa)
	lama5	Laminin, alpha 5. (3664 aa)
	pho	Phoenix. (2798 aa)
	nr3c1	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa)
	prl	Prolactin. (210 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (616 aa)
	eef1g	Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (442 aa)
	hspd1	Heat shock 60kD protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family. (575 aa)
	ctcf	CCCTC-binding factor (zinc finger protein). (798 aa)
	nrg2a	Zgc:162973 protein. (488 aa)
	vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
	pbx4	Pre-B-cell leukemia transcription factor 4. (343 aa)
	nr0b1	Nuclear receptor subfamily 0, group B, member 1. (302 aa)
	prdm5	PR domain-containing 5. (634 aa)
	fam32a	Protein FAM32A-like; May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli; Belongs to the FAM32 family. (109 aa)
	gle1	Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa)
	esr2a	Estrogen receptor beta2. (553 aa)
	pknox1.1	Homeodomain transcription factor Prep1. (433 aa)
	fbxw7	F-box and WD repeat domain-containing 7. (544 aa)
	greb1l	GREB1-like protein; Plays a major role in early metanephros development. Belongs to the GREB1 family. (1942 aa)
	cox5aa	Cytochrome c oxidase subunit 5Aa. (141 aa)
	ahctf1	AT hook-containing transcription factor 1. (2527 aa)
	lamb1a	Laminin, beta 1a. (1785 aa)
	flt4	Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
	slc1a2b	Amino acid transporter. (564 aa)
	ddx46	Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1018 aa)
	itgb1b	Integrin beta; Belongs to the integrin beta chain family. (521 aa)
	cox5ab	Cytochrome c oxidase subunit 5Ab. (138 aa)
	pbx1a	Pre-B-cell leukemia transcription factor 1a. (428 aa)
	tfec	Transcription factor EC. (396 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cox5aa	cox5ab	ENSDARP00000123538	ENSDARP00000138508	Cytochrome c oxidase subunit 5Aa.	Cytochrome c oxidase subunit 5Ab.	0.908
cox5aa	eef1g	ENSDARP00000123538	ENSDARP00000072983	Cytochrome c oxidase subunit 5Aa.	Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.	0.470
cox5aa	surf1	ENSDARP00000123538	ENSDARP00000009060	Cytochrome c oxidase subunit 5Aa.	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	0.600
cox5ab	cox5aa	ENSDARP00000138508	ENSDARP00000123538	Cytochrome c oxidase subunit 5Ab.	Cytochrome c oxidase subunit 5Aa.	0.908
cox5ab	surf1	ENSDARP00000138508	ENSDARP00000009060	Cytochrome c oxidase subunit 5Ab.	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	0.729
eef1g	cox5aa	ENSDARP00000072983	ENSDARP00000123538	Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.	Cytochrome c oxidase subunit 5Aa.	0.470
eef1g	hspd1	ENSDARP00000072983	ENSDARP00000073057	Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.	Heat shock 60kD protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family.	0.496
esr2a	nr0b1	ENSDARP00000110930	ENSDARP00000105523	Estrogen receptor beta2.	Nuclear receptor subfamily 0, group B, member 1.	0.471
flt4	itgb1b	ENSDARP00000133227	ENSDARP00000137182	Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis.	Integrin beta; Belongs to the integrin beta chain family.	0.589
flt4	vegfc	ENSDARP00000133227	ENSDARP00000092263	Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.999
hspd1	eef1g	ENSDARP00000073057	ENSDARP00000072983	Heat shock 60kD protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family.	Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.	0.496
itgb1b	flt4	ENSDARP00000137182	ENSDARP00000133227	Integrin beta; Belongs to the integrin beta chain family.	Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis.	0.589
itgb1b	lama5	ENSDARP00000137182	ENSDARP00000045125	Integrin beta; Belongs to the integrin beta chain family.	Laminin, alpha 5.	0.789
itgb1b	lamb1a	ENSDARP00000137182	ENSDARP00000131540	Integrin beta; Belongs to the integrin beta chain family.	Laminin, beta 1a.	0.808
lama5	itgb1b	ENSDARP00000045125	ENSDARP00000137182	Laminin, alpha 5.	Integrin beta; Belongs to the integrin beta chain family.	0.789
lama5	lamb1a	ENSDARP00000045125	ENSDARP00000131540	Laminin, alpha 5.	Laminin, beta 1a.	0.856
lamb1a	itgb1b	ENSDARP00000131540	ENSDARP00000137182	Laminin, beta 1a.	Integrin beta; Belongs to the integrin beta chain family.	0.808
lamb1a	lama5	ENSDARP00000131540	ENSDARP00000045125	Laminin, beta 1a.	Laminin, alpha 5.	0.856
nr0b1	esr2a	ENSDARP00000105523	ENSDARP00000110930	Nuclear receptor subfamily 0, group B, member 1.	Estrogen receptor beta2.	0.471
nr3c1	prl	ENSDARP00000054263	ENSDARP00000055298	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	Prolactin.	0.463

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