STRINGSTRING
tbx6 tbx6 smn1 smn1 isl2a isl2a chodl chodl plxna3 plxna3 fus fus tbc1d23 tbc1d23 epas1b epas1b gars1 gars1 sdc4 sdc4 plod3 plod3 col15a1b col15a1b kif15 kif15 ccndx ccndx col19a1 col19a1 mnx2b mnx2b insm1a insm1a mecp2 mecp2 ncaldb ncaldb stim1a stim1a appb appb chp1 chp1 prdm14 prdm14 grna grna fignl1 fignl1 ppp1r12a ppp1r12a nrxn2a nrxn2a met met notum2 notum2 plxnb1b plxnb1b agrn agrn syn2b syn2b hnrnpr hnrnpr sema5a sema5a notch1a notch1a nrp1a nrp1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
smn1Survival motor neuron protein 1; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites. (281 aa)
isl2aInsulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. (359 aa)
chodlChondrolectin; Plays a role in the development of the nervous system such as in neurite outgrowth and elongation. Involved in motor axon growth and guidance. Required for correct interactions of motor axons with the horizontal myoseptum. (296 aa)
plxna3Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. (1892 aa)
fusFUS RNA-binding protein. (541 aa)
tbc1d23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development. May act as a general inhibitor of innate immunity signaling (By similarity). (680 aa)
epas1bEndothelial PAS domain protein 1b. (834 aa)
gars1Glycyl-tRNA synthetase. (690 aa)
sdc4Syndecan 4. (207 aa)
plod3Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3. (730 aa)
col15a1bCollagen, type XV, alpha 1b. (1245 aa)
kif15Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1378 aa)
ccndxCyclin Dx; Belongs to the cyclin family. (324 aa)
col19a1Collagen, type XIX, alpha 1. (303 aa)
mnx2bMotor neuron and pancreas homeobox 2b. (328 aa)
insm1aInsulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
ncaldbNeurocalcin-delta B; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). (192 aa)
stim1aStromal interaction molecule 1a. (676 aa)
appbAmyloid beta (A4) precursor protein b. (694 aa)
chp1Calcineurin-like EF-hand protein 1. (194 aa)
prdm14PR domain-containing 14. (568 aa)
grnaGranulin a. (1049 aa)
fignl1Fidgetin-like 1; Belongs to the AAA ATPase family. (661 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
nrxn2aNeurexin 2a. (648 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
notum2Carboxylesterase notum2; Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling. (495 aa)
plxnb1bPlexin b1b. (2220 aa)
agrnAgrin. (1926 aa)
syn2bSynapsin IIb. (695 aa)
hnrnprHeterogeneous nuclear ribonucleoprotein R. (637 aa)
sema5aSemaphorin-5A. (1048 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
nrp1aNeuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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