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dmrt2a dmrt2a lft1 lft1 mespaa mespaa llgl2 llgl2 prrx1a prrx1a znf703 znf703 dand5 dand5 rps14 rps14 cftr cftr MYO1D MYO1D fsd1 fsd1 ephb4b ephb4b atp6ap1b atp6ap1b cenpf cenpf atr atr cep162 cep162 cntrob cntrob meis3 meis3 nme3 nme3 wtip wtip mcm2 mcm2 cfap53 cfap53 axin1 axin1 tekt1 tekt1 tbxta tbxta
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dmrt2aDoublesex and mab-3-related transcription factor 2a. (507 aa)
lft1Left-right determination factor; Belongs to the TGF-beta family. (358 aa)
mespaaMesp-related bHLH transcription factor mesp-a. (223 aa)
llgl2LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family. (1020 aa)
prrx1aPaired-related homeobox 1a. (245 aa)
znf703Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Required for segmental gene expression during hindbrain development. May regulate cell adhesion, migration and proliferation. (589 aa)
dand5DAN domain family, member 5. (243 aa)
rps14Ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1485 aa)
MYO1DUnconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric developm [...] (1004 aa)
fsd1Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. (495 aa)
ephb4bEphrin type-B receptor 4b; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] (976 aa)
atp6ap1bATPase H+-transporting accessory protein 1b. (459 aa)
cenpfCentromere protein F. (2708 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
cep162Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. (1367 aa)
cntrobCentrobin, centrosomal BRCA2-interacting protein. (77 aa)
meis3Myeloid ecotropic viral integration site 3. (415 aa)
nme3Nucleoside diphosphate kinase. (169 aa)
wtipWilms tumor protein 1-interacting protein homolog; May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development (By similarity); Belongs to the zyxin/ajuba family. (648 aa)
mcm2DNA helicase; Belongs to the MCM family. (889 aa)
cfap53Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis; Belongs to the CFAP53 family. (519 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
tekt1Tektin 1. (402 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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