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rpl35 | 60S ribosomal protein L35; Plays an essential role in early embryonic development. May act as a haploinsufficient tumor suppressor. Belongs to the universal ribosomal protein uL29 family. (123 aa) | ||||
lats2 | Large tumor suppressor kinase 2. (1140 aa) | ||||
tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) | ||||
kdm2aa | Lysine (K)-specific demethylase 2Aa. (1242 aa) | ||||
tert | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa) |