STRINGSTRING
hnf1a hnf1a pax4 pax4 klhl42 klhl42 pdx1 pdx1 fitm2 fitm2 ins ins kcnj11 kcnj11 zfand3 zfand3 thada thada gck gck c2cd4a c2cd4a srebf1 srebf1 camk1da camk1da alms1 alms1 bbs1 bbs1 bbs4 bbs4 notch2 notch2 hnf4a hnf4a glis3 glis3 adamts9 adamts9 zgc:153115 zgc:153115 hnf1ba hnf1ba gckr gckr wfs1b wfs1b ankrd55 ankrd55 slc30a8 slc30a8 cdkal1 cdkal1 ide ide pepd pepd pparg pparg
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hnf1aHNF1 homeobox a. (560 aa)
pax4Paired box 4. (344 aa)
klhl42Kelch-like family, member 42. (472 aa)
pdx1Pancreatic and duodenal homeobox 1. (246 aa)
fitm2Fat storage-inducing transmembrane protein 2; May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Plays an important role in lipid droplet accumulation in liver and intestine during embryogenesis. (252 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
kcnj11Potassium inwardly-rectifying channel, subfamily J, member 11. (381 aa)
zfand3Zinc finger, AN1-type domain 3. (226 aa)
thadaTHADA armadillo repeat-containing. (364 aa)
gckPhosphotransferase. (298 aa)
c2cd4aC2 calcium-dependent domain-containing 4A. (457 aa)
srebf1Sterol regulatory element-binding transcription factor 1. (879 aa)
camk1daCalcium/calmodulin-dependent protein kinase 1Da; Belongs to the protein kinase superfamily. (433 aa)
alms1ALMS1 centrosome and basal body-associated protein. (2105 aa)
bbs1Bardet-Biedl syndrome 1. (588 aa)
bbs4Bardet-Biedl syndrome 4. (528 aa)
notch2Notch receptor 2. (2475 aa)
hnf4aHepatocyte nuclear factor 4, alpha. (463 aa)
glis3GLIS family zinc finger 3. (803 aa)
adamts9ADAM metallopeptidase with thrombospondin type 1 motif, 9. (1461 aa)
zgc:153115Zgc:153115. (250 aa)
hnf1baHepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa)
gckrGlucokinase (hexokinase 4) regulator. (281 aa)
wfs1bWolfram syndrome 1b (wolframin). (895 aa)
ankrd55Ankyrin repeat domain 55. (650 aa)
slc30a8Solute carrier family 30 member 8. (388 aa)
cdkal1Threonylcarbamoyladenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Belongs to the methylthiotransferase family. CDKAL1 subfamily. (250 aa)
ideNovel protein similar to H.sapiens IDE, insulin-degrading enzyme (IDE, zgc:162603); Belongs to the peptidase M16 family. (998 aa)
pepdPeptidase D. (496 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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