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slc40a1 slc40a1 adam8a adam8a gata1a gata1a hey2 hey2 sh3gl3b sh3gl3b rad21a rad21a bco2l bco2l dnmt1 dnmt1 itga2b itga2b pdcd2 pdcd2 gfi1aa gfi1aa racgap1 racgap1 trim33 trim33 tdg.1 tdg.1 epb41b epb41b mylka mylka rps19 rps19 dnmt3bb.1 dnmt3bb.1 socs1a socs1a alas2 alas2 fbxo5 fbxo5 lrrc32 lrrc32 shoc2 shoc2 rad51 rad51 s1pr1 s1pr1 ccnb1 ccnb1 rpl11 rpl11 bambia bambia gata2a gata2a jam3b jam3b slc25a37 slc25a37 lrrc15 lrrc15 opa1 opa1 arhgef7b arhgef7b tet2 tet2 piezo1 piezo1 esama esama tnfrsf1b tnfrsf1b pard3ab pard3ab vegfba vegfba rps7 rps7 slc4a1a slc4a1a ncoa1 ncoa1 cald1b cald1b sptb sptb pank2 pank2 sh3kbp1 sh3kbp1 epg5 epg5 dcbld2 dcbld2 tert tert aldh1l1 aldh1l1 f8 f8 tpcn2 tpcn2 tfr1a tfr1a apela apela uchl5 uchl5 ptpn21 ptpn21 fer fer
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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slc40a1Solute carrier family 40 member 1; May be involved in iron export and also in transfer of iron between maternal and fetal circulation. (562 aa)
adam8aA disintegrin and metalloproteinase domain 8a. (843 aa)
gata1aGATA-binding protein 1a. (418 aa)
hey2Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. (324 aa)
sh3gl3bSH3-domain GRB2-like 3b. (386 aa)
rad21aDouble-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...] (643 aa)
bco2lBeta-carotene 15, 15-dioxygenase 2,-like. (549 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
itga2bIntegrin, alpha 2b (Platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B); Belongs to the integrin alpha chain family. (1037 aa)
pdcd2Programmed cell death 2. (358 aa)
gfi1aaGrowth factor-independent 1A transcription repressor a. (385 aa)
racgap1Rac GTPase-activating protein 1. (654 aa)
trim33E3 ubiquitin-protein ligase TRIM33; May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells. (1176 aa)
tdg.1Thymine DNA glycosylase, tandem duplicate 1. (441 aa)
epb41bErythrocyte membrane protein band 4.1 (Elliptocytosis 1, RH-linked). (1534 aa)
mylkaMyosin, light chain kinase a. (899 aa)
rps19Ribosomal protein S19. (146 aa)
dnmt3bb.1DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (816 aa)
socs1aSuppressor of cytokine-signaling 1a. (201 aa)
alas25-aminolevulinate synthase, erythroid-specific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (583 aa)
fbxo5F-box only protein 5; During embryonic development, regulates the integrity of the genome and therefore the cell cycle progression by preventing rereplication through an APC-Cdh1-dependent mechanism. (384 aa)
lrrc32Leucine-rich repeat-containing 32. (659 aa)
shoc2Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and stimulate raf1 activity at specialized signaling complexes (By similarity). (561 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
s1pr1Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. (362 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (397 aa)
rpl1160S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
bambiaBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (258 aa)
gata2aGATA-binding protein 2a. (456 aa)
jam3bJunctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. (333 aa)
slc25a37Mitoferrin-1; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. (332 aa)
lrrc15Leucine-rich repeat-containing 15. (564 aa)
opa1Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). (966 aa)
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b. (799 aa)
tet2Tet methylcytosine dioxygenase 2. (1715 aa)
piezo1Piezo-type mechanosensitive ion channel component. (2436 aa)
esamaEndothelial cell adhesion molecule a. (428 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
pard3abPar-3 family cell polarity regulator alpha, b. (1332 aa)
vegfbaVascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family. (246 aa)
rps740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
slc4a1aAnion exchange protein. (905 aa)
ncoa1Nuclear receptor coactivator 1. (1349 aa)
cald1bCaldesmon 1b. (560 aa)
sptbSpectrin beta chain; Belongs to the spectrin family. (2357 aa)
pank2Pantothenate kinase 2. (437 aa)
sh3kbp1SH3-domain kinase-binding protein 1. (669 aa)
epg5Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity). (2532 aa)
dcbld2Discoidin, CUB and LCCL domain-containing 2. (661 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa)
aldh1l110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (903 aa)
f8Coagulation factor VIII, procoagulant component. (1674 aa)
tpcn2Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction (By similarity). (774 aa)
tfr1aTransferrin receptor 1a. (770 aa)
apelaApelin receptor early endogenous ligand; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast m [...] (58 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
ptpn21Protein tyrosine phosphatase non-receptor type 21. (1204 aa)
ferTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (862 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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