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degs1 degs1 dla dla smo smo pink1 pink1 neflb neflb glra4a glra4a gmds gmds olig2 olig2 fzd8a fzd8a leo1 leo1 ihhb ihhb psenen psenen swap70b swap70b abcd1 abcd1 dtx4a dtx4a mtor mtor auts2a auts2a slc33a1 slc33a1 loxa loxa htr1ab htr1ab il7r il7r l1camb l1camb otpa otpa pitpnaa pitpnaa als2b als2b cdc73 cdc73 mib1 mib1 agrn agrn ap1g2 ap1g2 gabra1 gabra1 hmgcs1 hmgcs1 drd4a drd4a ap1g1 ap1g1 adgrg1 adgrg1 prmt8b prmt8b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
degs1Delta(4)-desaturase, sphingolipid 1. (323 aa)
dlaDelta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] (772 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
pink1PTEN-induced kinase 1. (574 aa)
neflbNeurofilament, light polypeptide b; Belongs to the intermediate filament family. (579 aa)
glra4aGlycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
gmdsGDP-mannose 4,6 dehydratase. (370 aa)
olig2Oligodendrocyte lineage transcription factor 2. (273 aa)
fzd8aFrizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
leo1RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. (696 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
psenenGamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa)
swap70bSwitching B cell complex subunit SWAP70b. (588 aa)
abcd1ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination. (766 aa)
dtx4aDeltex 4, E3 ubiquitin ligase a. (704 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
auts2aActivator of transcription and developmental regulator AUTS2 a. (1278 aa)
slc33a1Solute carrier family 33 member 1. (541 aa)
loxaLysyl oxidase a. (408 aa)
htr1ab5-hydroxytryptamine (serotonin) receptor 1A b. (413 aa)
il7rInterleukin 7 receptor. (372 aa)
l1cambNeural cell adhesion molecule L1.1; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1332 aa)
otpaOrthopedia homeobox a. (332 aa)
pitpnaaPhosphatidylinositol transfer protein, alpha a. (271 aa)
als2bAlsin Rho guanine nucleotide exchange factor ALS2 b. (1681 aa)
cdc73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
agrnAgrin. (1926 aa)
ap1g2AP-1 complex subunit gamma. (794 aa)
gabra1Gamma-aminobutyric acid (GABA) A receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (459 aa)
hmgcs13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa)
drd4aDopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ap1g1AP-1 complex subunit gamma. (819 aa)
adgrg1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (648 aa)
prmt8bProtein arginine N-methyltransferase 8-B; S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily. (420 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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