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| | foxi3b | Forkhead box I3b. (383 aa) |
| | nfe2 | Nuclear factor, erythroid 2. (466 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | atp1b1a | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | prkci | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa) |
| | irf4a | Interferon regulatory factor 4a. (460 aa) |
| | hmcn1 | Hemicentin 1. (5616 aa) |
| | anos1a | Anosmin 1a. (652 aa) |
| | jag1b | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa) |
| | prps1a | Phosphoribosyl pyrophosphate synthetase 1A. (320 aa) |
| | wdr36 | WD repeat domain 36. (896 aa) |
| | olfm1a | Olfactomedin 1a. (485 aa) |
| | tcf7l2 | Transcription factor 7-like 2 (T-cell specific, HMG-box). (477 aa) |
| | rad21a | Double-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...] (643 aa) |
| | mep1a.2 | Meprin A subunit. (689 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | utp25 | Digestive organ expansion factor; Regulates the p53 pathway to control the expansion growth of digestive organs. Required for the expansion growth of intestine, liver and exocrine pancreas, but not endocrine pancreas. May not play a major role during the early stage of endodermal organogenesis. (753 aa) |
| | ptbp1a | Polypyrimidine tract-binding protein 1a. (574 aa) |
| | plod2 | Procollagen lysine 2-oxoglutarate 5-dioxygenase 2b isoform. (754 aa) |
| | mylipa | E3 ubiquitin-protein ligase MYLIP-A; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway. (472 aa) |
| | mmp13a | Matrix metallopeptidase 13a. (476 aa) |
| | ubiad1 | UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzym [...] (336 aa) |
| | bloc1s1 | Biogenesis of lysosomal organelles complex-1, subunit 1. (125 aa) |
| | dnmt1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa) |
| | dla | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] (772 aa) |
| | fgfr1a | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa) |
| | traf4a | TNF receptor-associated factor. (470 aa) |
| | pip5k1ab | Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b. (584 aa) |
| | atp6v0ca | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa) |
| | copz1 | Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (198 aa) |
| | sept9a | Septin 9a; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (587 aa) |
| | igf1ra | Tyrosine-protein kinase receptor. (1405 aa) |
| | rsph9 | Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. (277 aa) |
| | col14a1a | Collagen, type XIV, alpha 1a. (1864 aa) |
| | gfi1aa | Growth factor-independent 1A transcription repressor a. (385 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | chm | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa) |
| | znf503 | Zinc finger protein 503; Required for segmental gene expression during hindbrain development. May function as a transcriptional repressor. Belongs to the Elbow/Noc family. (563 aa) |
| | mab21l2 | Protein mab-21-like 2; Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells; Belongs to the mab-21 family. (359 aa) |
| | rnpc3 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprise less than 1% of all non-coding sequences. (505 aa) |
| | wif1 | Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. (378 aa) |
| | ptgs2a | Prostaglandin-endoperoxide synthase 2a. (601 aa) |
| | cse1l | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). Negatively regulates fluid secretion and plays a role in fluid homeostasis by downregulating cftr activity. (971 aa) |
| | ezh2 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa) |
| | ptch1 | Protein patched homolog 1. (1475 aa) |
| | slc12a3 | Solute carrier family 12 member 3. (1012 aa) |
| | hsf4 | Heat shock transcription factor 4. (286 aa) |
| | gata5 | Transcription factor gata5. (383 aa) |
| | dhrs9 | Dehydrogenase/reductase (SDR family) member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa) |
| | six1b | Homeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa) |
| | slc24a5 | Sodium/potassium/calcium exchanger 5; Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (513 aa) |
| | tbx5a | T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa) |
| | sec61a1 | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. (476 aa) |
| | pax8 | Paired box 8. (448 aa) |
| | suv39h1a | Histone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa) |
| | llgl2 | LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family. (1020 aa) |
| | slc45a2 | Solute carrier family 45 member 2. (554 aa) |
| | sparc | Secreted protein, acidic, cysteine-rich (osteonectin). (291 aa) |
| | nup107 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (919 aa) |
| | tbx1 | T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa) |
| | myh11a | Myosin, heavy polypeptide 11, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa) |
| | lama5 | Laminin, alpha 5. (3664 aa) |
| | etv2 | ETS variant transcription factor 2. (366 aa) |
| | pmelb | Premelanosome protein b. (616 aa) |
| | ldlra | Low density lipoprotein receptor a. (911 aa) |
| | igf1rb | Tyrosine-protein kinase receptor. (1380 aa) |
| | tyms | Thymidylate synthetase. (318 aa) |
| | gpr143 | G protein-coupled receptor 143. (412 aa) |
| | paics | Phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase. (1042 aa) |
| | fgf10a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa) |
| | atp6v1e1b | ATPase H+-transporting V1 subunit E1b. (226 aa) |
| | rps6ka3a | Ribosomal protein S6 kinase. (732 aa) |
| | znf703 | Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Required for segmental gene expression during hindbrain development. May regulate cell adhesion, migration and proliferation. (589 aa) |
| | hdac1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa) |
| | pitpnb | Phosphatidylinositol transfer protein, beta. (272 aa) |
| | pard6gb | Par-6 partitioning defective 6-like protein gamma. (434 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | vps11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa) |
| | s1pr2 | Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa) |
| | has2 | Hyaluronan synthase 2. (552 aa) |
| | nr3c1 | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa) |
| | snrnp70 | Small nuclear ribonucleoprotein 70 (U1). (495 aa) |
| | flr | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. (651 aa) |
| | ascl1a | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. (196 aa) |
| | mitfa | Microphthalmia-associated transcription factor a. (412 aa) |
| | nsfb | N-ethylmaleimide-sensitive factor b. (747 aa) |
| | terfa | Telomeric repeat-binding factor a. (574 aa) |
| | emx2 | Empty spiracles homeobox 2. (247 aa) |
| | dync2li1 | Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi- directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length. (358 aa) |
| | rps29 | Ribosomal protein S29. (56 aa) |
| | pip5k1ca | Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a. (682 aa) |
| | vgll2a | Vestigial-like family member 2a. (296 aa) |
| | oxt | Oxytocin; Belongs to the vasopressin/oxytocin family. (154 aa) |
| | cxadr | Coxsackievirus and adenovirus receptor homolog; May function as a homophilic cell adhesion molecule and be essential for tight junction integrity. May also be involved in transepithelial migration of leukocytes through adhesive interactions with jaml. The interaction between both receptors may also mediate the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair (By similarity). (372 aa) |
| | tp63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (588 aa) |
| | abcc4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4. (1327 aa) |
| | atp6v1f | V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa) |
| | stk11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | rag2 | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (530 aa) |
| | rx3 | Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa) |
| | apln | Apelin; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Drives internalization of the apelin receptor (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis (By similarity). (77 aa) |
| | aldh1a2 | Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | fbl | Fibrillarin. (317 aa) |
| | lmx1bb | LIM homeobox transcription factor 1, beta 1. (375 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) |
| | ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) |
| | atp2b1a | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1228 aa) |
| | cdc16 | Cell division cycle 16 homolog (S. cerevisiae). (616 aa) |
| | foxi3a | Forkhead box I3a. (353 aa) |
| | ext2 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa) |
| | ilk | Integrin-linked kinase. (452 aa) |
| | ikzf1 | IKAROS family zinc finger 1 (Ikaros). (526 aa) |
| | wdr34 | WD repeat domain 34. (501 aa) |
| | ctsd | Ctsd protein; Belongs to the peptidase A1 family. (398 aa) |
| | atp1a1a.1 | Sodium/potassium-transporting ATPase subunit alpha. (1028 aa) |
| | stc1l | Stanniocalcin 1,-like. (249 aa) |
| | bves | Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa) |
| | ihha | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa) |
| | gsc | Homeobox protein goosecoid. (240 aa) |
| | homer2 | Homer scaffold protein 2. (175 aa) |
| | tal1 | T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa) |
| | crb2a | Crumbs cell polarity complex component 2a. (1466 aa) |
| | lrrn1 | Leucine-rich repeat neuronal 1. (717 aa) |
| | hhip | Hedgehog-interacting protein. (693 aa) |
| | foxp3a | Forkhead box protein. (419 aa) |
| | ush2a | Usher syndrome 2A (autosomal recessive, mild). (5236 aa) |
| | vps45 | Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (568 aa) |
| | dot1l | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1454 aa) |
| | stra6l | STRA6-like. (609 aa) |
| | pllp | Novel protein similar to vertebrate transmembrane 4 superfamily member 11 (Plasmolipin) (TM4SF11). (173 aa) |
| | foxe3 | Forkhead box E3. (422 aa) |
| | polr3b | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1130 aa) |
| | yap1 | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa) |
| | slc25a37 | Mitoferrin-1; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. (332 aa) |
| | atp6v0d1 | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) p [...] (350 aa) |
| | sema3d | Semaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa) |
| | pik3c3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa) |
| | vegfc | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa) |
| | ptger4a | Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (403 aa) |
| | bcor | BCL6 corepressor. (1796 aa) |
| | clcn7 | Chloride channel protein. (795 aa) |
| | vhl | Von Hippel-Lindau tumor suppressor. (175 aa) |
| | cdipt | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa) |
| | chsy1 | Hexosyltransferase. (801 aa) |
| | hps5 | Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1133 aa) |
| | mif | Macrophage migration inhibitory factor. (115 aa) |
| | camk2g1 | Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1. (560 aa) |
| | grhl3 | Grainyhead-like transcription factor 3. (557 aa) |
| | klf4 | Kruppel-like factor 4. (340 aa) |
| | atxn7 | Ataxin 7. (866 aa) |
| | arhgef19 | Rho guanine nucleotide exchange factor (GEF) 19. (958 aa) |
| | kank3 | KN motif and ankyrin repeat domains 3. (914 aa) |
| | sox10 | HMG-box transcription factor Sox10. (485 aa) |
| | dlx5a | Homeobox protein Dlx5a; Belongs to the distal-less homeobox family. (282 aa) |
| | get1 | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. (170 aa) |
| | vps39 | VPS39 subunit of HOPS complex. (875 aa) |
| | pwp2h | PWP2 small subunit processome component. (937 aa) |
| | hmx1 | H6 family homeobox 1. (282 aa) |
| | frem2a | Fras1-like extracellular matrix protein 2a. (3119 aa) |
| | adgra2 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] (1367 aa) |
| | ptgs1 | Prostaglandin-endoperoxide synthase 1. (597 aa) |
| | wnt3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | erbb3b | Erb-b2 receptor tyrosine kinase 3b. (1429 aa) |
| | mtor | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa) |
| | prox3 | Prospero-like protein Prox1b. (659 aa) |
| | zic1 | ZIC family member 1 (Odd-paired homolog, Drosophila). (442 aa) |
| | marcksa | Myristoylated alanine-rich protein kinase C substrate a. (236 aa) |
| | cyp1b1 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa) |
| | kif3a | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa) |
| | bcl6aa | BCL6A transcription repressor a. (718 aa) |
| | pmela | Premelanosome protein a. (825 aa) |
| | kif17 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (823 aa) |
| | pard3ab | Par-3 family cell polarity regulator alpha, b. (1332 aa) |
| | atp6ap2 | ATPase H+-transporting accessory protein 2. (386 aa) |
| | mecp2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa) |
| | atp6ap1b | ATPase H+-transporting accessory protein 1b. (459 aa) |
| | gle1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa) |
| | mfrp | Membrane frizzled-related protein. (572 aa) |
| | dnmt3bb.2 | DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1448 aa) |
| | esr2a | Estrogen receptor beta2. (553 aa) |
| | tyr | Tyrosinase. (535 aa) |
| | fn1a | Fibronectin 1a. (2480 aa) |
| | hnf4a | Hepatocyte nuclear factor 4, alpha. (463 aa) |
| | atp6v1h | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (481 aa) |
| | sox18 | SRY-box transcription factor 18. (431 aa) |
| | clint1a | Clathrin interactor 1a. (633 aa) |
| | lrmda | Leucine-rich melanocyte differentiation-associated. (234 aa) |
| | chd7 | Chromodomain helicase DNA-binding protein 7. (3140 aa) |
| | pomgnt2 | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affini [...] (585 aa) |
| | snap29 | Synaptosome-associated protein 29. (232 aa) |
| | eya1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa) |
| | pth1a | Parathyroid hormone 1a. (102 aa) |
| | plcg1 | Phosphoinositide phospholipase C. (1020 aa) |
| | abca12 | ATP-binding cassette, sub-family A (ABC1), member 12. (1809 aa) |
| | epg5 | Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity). (2532 aa) |
| | ap1b1 | AP complex subunit beta. (947 aa) |
| | col17a1a | Collagen, type XVII, alpha 1a. (1408 aa) |
| | greb1l | GREB1-like protein; Plays a major role in early metanephros development. Belongs to the GREB1 family. (1942 aa) |
| | epb41l5 | Erythrocyte membrane protein band 4.1-like 5. (461 aa) |
| | lhx2b | LIM homeobox 2b. (427 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | oca2 | Oculocutaneous albinism II. (809 aa) |
| | mllt10 | MLLT10 histone lysine methyltransferase DOT1L cofactor. (1133 aa) |
| | pcdh19 | Protocadherin 19. (1088 aa) |
| | grhl2b | Grainyhead-like transcription factor 2b. (601 aa) |
| | wdr43 | WD repeat domain 43. (650 aa) |
| | tnnt2a | Troponin T type 2a (cardiac). (282 aa) |
| | tert | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | kcnj13 | Potassium inwardly rectifying channel subfamily J member 13. (362 aa) |
| | ahctf1 | AT hook-containing transcription factor 1. (2527 aa) |
| | p4htm | Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum). (510 aa) |
| | pip5k1aa | Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a. (559 aa) |
| | cib2 | Calcium and integrin-binding family member 2. (187 aa) |
| | sphk2 | Sphingosine kinase 2. (869 aa) |
| | gart | Phosphoribosylglycinamide formyltransferase. (1015 aa) |
| | sbno2a | Strawberry notch homolog 2a. (1350 aa) |
| | tmprss4a | Transmembrane serine protease 4a; Belongs to the peptidase S1 family. (430 aa) |
| | crb2b | Crumbs cell polarity complex component 2b. (1010 aa) |
| | tln1 | Talin 1. (2544 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | atp6v0e1 | V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa) |
| | ca5a | Carbonic anhydrase Va; Belongs to the alpha-carbonic anhydrase family. (310 aa) |
| | kif3b | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (775 aa) |
| | sufu | Suppressor of fused homolog. (485 aa) |
| | foxi1 | Forkhead box I1. (377 aa) |
| | pycr1a | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa) |
| | sept15 | Septin 15; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (429 aa) |
| | uhrf1 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa) |
| | ddx46 | Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1018 aa) |
| | axin1 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa) |
| | unc45a | Unc-45 myosin chaperone A. (935 aa) |
| | fras1 | Fraser extracellular matrix complex subunit 1. (4003 aa) |
| | myo5b | Myosin VB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1839 aa) |
| | krit1 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa) |
| | apc | APC regulator of WNT-signaling pathway. (2754 aa) |
| | irf6 | Interferon regulatory factor 6. (492 aa) |
| | crb3a | Crumbs-like protein 3a. (109 aa) |
| | pdzd7a | PDZ domain-containing 7a. (954 aa) |
| | nop14 | NOP14 nucleolar protein homolog (yeast). (767 aa) |
| | sf3a3 | Splicing factor 3a, subunit 3. (501 aa) |
| | clrn1 | Clrn1 protein. (232 aa) |
| | qkia | Protein quaking-A; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (383 aa) |
| | nrp1a | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa) |
| | sbno1 | Strawberry notch homolog 1 (Drosophila). (1385 aa) |
| | cav1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa) |
| | pycr1b | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (329 aa) |
| | cbfb | Core-binding factor subunit beta. (201 aa) |
| | svep1 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1. (3615 aa) |
| | smarca4a | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4a. (1627 aa) |
| | slc2a3a | Solute carrier family 2 member 3a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa) |
| | lingo2a | Leucine-rich repeat and Ig domain-containing 2a. (628 aa) |
| | tomt | Transmembrane O-methyltransferase homolog; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity. (259 aa) |
| | sox7 | SRY-box transcription factor 7. (390 aa) |
| | tie1 | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. (1150 aa) |
| | spint1a | Serine peptidase inhibitor, Kunitz type 1 a. (523 aa) |
| | npas4l | Neuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa) |
| | pax6b | Paired box 6b. (450 aa) |
| | cdx1b | Caudal type homeodomain protein. (255 aa) |
| | DYNC2H1 | Dynein cytoplasmic 2 heavy chain 1. (4208 aa) |
| | ripply1 | Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. (140 aa) |
| | ubr3 | E3 ubiquitin-protein ligase ubr3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (By similarity). Positively regulates hedgehog/shh-signaling pathways that function in eye development, neuronal specification and somite development. Activation of shh up-regulates transcription of ubr3, which in turn promotes hedgehog/shh signaling possibly by controlling negative regulators such as Kif7. (1863 aa) |
| | tfap2a | Transcription factor AP-2 alpha. (450 aa) |
