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| | dmd | Dystrophin. (594 aa) |
| | prdm1a | PR domain-containing 1a, with ZNF domain. (776 aa) |
| | her7 | Hairy and enhancer of split-related-7. (206 aa) |
| | mmp2 | Matrix metalloproteinase 2. (657 aa) |
| | gpc4 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | sulf2a | Extracellular sulfatase. (873 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | plod2 | Procollagen lysine 2-oxoglutarate 5-dioxygenase 2b isoform. (754 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | tbx6 | T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa) |
| | mafba | Transcription factor MafB; May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. Belongs to the bZIP family. Maf subfamily. (397 aa) |
| | dag1 | Dystroglycan 1. (866 aa) |
| | npnta | Nephronectin a. (605 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | gmppb | Mannose-1-phosphate guanyltransferase beta; Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. (360 aa) |
| | orai1b | Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores; Belongs to the Orai family. (222 aa) |
| | unc45b | Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa) |
| | kmo | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (474 aa) |
| | ptch1 | Protein patched homolog 1. (1475 aa) |
| | tcap | Titin-cap (telethonin). (179 aa) |
| | scxb | Scleraxis bHLH transcription factor b. (200 aa) |
| | itga5 | Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1053 aa) |
| | dpf3 | Zinc finger protein DPF3; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). Plays an essential role in heart and skeletal [...] (391 aa) |
| | llgl2 | LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family. (1020 aa) |
| | itgb1a | Integrin beta; Belongs to the integrin beta chain family. (798 aa) |
| | myh11a | Myosin, heavy polypeptide 11, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa) |
| | chrd | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | myo1ca | Unconventional myosin-Ic; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). (1045 aa) |
| | nr3c1 | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa) |
| | scube2 | Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa) |
| | hdac3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa) |
| | atoh8 | Protein atonal homolog 8; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). During development, is required for heart looping and swim bladder formation by acting in concert with GATA4 AND ZFPM1. During the development of both the retina and skeletal muscles is required for neural retinal cell through modulating PAX6 and NEUROG3 expression and myogenic differentiation. (266 aa) |
| | sulf1 | Sulfatase FP1c. (1099 aa) |
| | fer1l6 | Fer-1-like family member 6. (1790 aa) |
| | cacnb1 | Calcium channel, voltage-dependent, beta 1 subunit. (603 aa) |
| | dharma | Dharma. (192 aa) |
| | myo6b | Myosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1267 aa) |
| | cadm1b | Cell adhesion molecule 1b. (370 aa) |
| | lurap1 | Leucine-rich adaptor protein 1. (286 aa) |
| | disp1 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa) |
| | st8sia3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (374 aa) |
| | b3galnt2 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O- glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (dag1) glycosylation; Belongs to the glycosyltransferase 31 family. (491 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) |
| | ext2 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa) |
| | kirrel1b | Kirre-like nephrin family adhesion molecule 1b. (790 aa) |
| | ctsd | Ctsd protein; Belongs to the peptidase A1 family. (398 aa) |
| | bves | Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa) |
| | gars1 | Glycyl-tRNA synthetase. (690 aa) |
| | fktn | Fukutin. (457 aa) |
| | tecta | Tectorin alpha. (2201 aa) |
| | ptger3 | Prostaglandin E receptor 3 (subtype EP3). (401 aa) |
| | col6a2 | Collagen, type VI, alpha 2. (1015 aa) |
| | sypb | Synaptophysin b. (297 aa) |
| | ripor2 | Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis an [...] (1083 aa) |
| | col15a1b | Collagen, type XV, alpha 1b. (1245 aa) |
| | myo18ab | Myosin XVIIIAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2557 aa) |
| | ambra1a | Activating molecule in beclin-1-regulated autophagy. (1315 aa) |
| | itga6b | Integrin, alpha 6b; Belongs to the integrin alpha chain family. (1085 aa) |
| | cd2ap | CD2-associated protein. (657 aa) |
| | usp40 | Ubiquitin-specific peptidase 40; Belongs to the peptidase C19 family. (1263 aa) |
| | meox1 | Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa) |
| | nav1b | Neuron navigator 1b. (1790 aa) |
| | itga6a | Integrin, alpha 6a; Belongs to the integrin alpha chain family. (1092 aa) |
| | cdhr1a | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. (857 aa) |
| | blzf1 | Basic leucine zipper nuclear factor 1. (394 aa) |
| | col6a4a | Collagen, type VI, alpha 4a. (2543 aa) |
| | dzip1 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa) |
| | prmt6 | Protein arginine N-methyltransferase 6; Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on [...] (355 aa) |
| | insm1a | Insulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa) |
| | plce1 | Phospholipase C, epsilon 1. (2248 aa) |
| | elp3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] (533 aa) |
| | cadm4 | Cell adhesion molecule 4. (413 aa) |
| | dcaf8 | DDB1 and CUL4-associated factor 8. (607 aa) |
| | scxa | Scleraxis bHLH transcription factor a. (199 aa) |
| | tyro3 | Tyrosine-protein kinase receptor TYRO3; May be involved in cell adhesion processes, particularly in the central nervous system; Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. (868 aa) |
| | arhgef28a | Rho guanine nucleotide exchange factor (GEF) 28a. (1753 aa) |
| | mef2aa | Myocyte enhancer factor 2aa. (458 aa) |
| | neb | Nebulin. (6177 aa) |
| | myof | Myoferlin. (2030 aa) |
| | cux2b | Homeobox protein cut-like. (1356 aa) |
| | selenon | Selenoprotein N; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Plays an important role [...] (557 aa) |
| | tbc1d8b | TBC1 domain family member 8B; Involved in vesicular recycling, probably as a GTPase- activating protein for Rab family protein(s). (1108 aa) |
| | las1l | LAS1-like ribosome biogenesis factor. (580 aa) |
| | iqgap2 | IQ motif-containing GTPase-activating protein 2. (1680 aa) |
| | epb41l5 | Erythrocyte membrane protein band 4.1-like 5. (461 aa) |
| | lamb2 | Laminin, beta 2 (laminin S). (1782 aa) |
| | fxr1 | Fragile X mental retardation, autosomal homolog 1. (645 aa) |
| | apobec2a | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2a. (266 aa) |
| | myh9a | Myosin, heavy chain 9a, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | myo1cb | Myosin Ic, paralog b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1028 aa) |
| | synpo2lb | Synaptopodin 2-like b. (1184 aa) |
| | nova2 | NOVA alternative-splicing regulator 2. (517 aa) |
| | map1ab | Microtubule-associated protein 1Ab. (3737 aa) |
| | kank2 | KN motif and ankyrin repeat domain-containing protein 2; May be involved in different biological processes including transcription and apoptosis by sequestering specific proteins outside of the nucleus (By similarity). Involved in actin stress fibers formation probably through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. (1085 aa) |
| | sptbn5 | Spectrin, beta, non-erythrocytic 5. (4140 aa) |
| | p4htm | Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum). (510 aa) |
| | ambra1b | Autophagy/beclin-1 regulator 1b. (1360 aa) |
| | actc1b | Actin, alpha 1, skeletal muscle. (377 aa) |
| | f8 | Coagulation factor VIII, procoagulant component. (1674 aa) |
| | sil1 | SIL1 nucleotide exchange factor. (463 aa) |
| | lama2 | Laminin, alpha 2. (845 aa) |
| | coq8b | Atypical kinase COQ8B, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration. (624 aa) |
| | fkrp | Fukutin-related protein. (536 aa) |
| | ntn1a | Netrin-1a. (603 aa) |
| | mibp2 | Muscle-specific beta 1 integrin-binding protein 2. (203 aa) |
| | apol1 | Apolipoprotein L, 1. (326 aa) |
| | uhrf1 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa) |
| | ints1 | Integrator complex subunit 1. (2192 aa) |
| | lama1 | Laminin, alpha 1. (3075 aa) |
| | adss1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (456 aa) |
| | itgb1b | Integrin beta; Belongs to the integrin beta chain family. (521 aa) |
| | dcc | DCC netrin 1 receptor. (1200 aa) |
| | col22a1 | Collagen, type XXII, alpha 1. (1622 aa) |
| | thsd7aa | Thrombospondin type-1 domain-containing protein 7A; Required for normal sprouting angiogenesis and normal embryonic development of intersegmental vessels (ISV). Required for normal function of the glomerular filtration barrier. Required for normal axon outgrowth on embryonic motor neurons at the level of the horizontal myoseptum. Required for normal expression of notch1b, suggesting that its functions in angiogenesis and neuron outgrowth are due to decreased expression of notch1b. Plays a role in actin cytoskeleton rearrangement (By similarity). (1684 aa) |
| | shroom3 | Shroom family member 3. (1565 aa) |
| | kirrel3l | Kirre-like nephrin family adhesion molecule 3, like. (755 aa) |
| | musk | Muscle, skeletal, receptor tyrosine kinase. (351 aa) |
| | tbcd | Tubulin folding cofactor D. (1191 aa) |
| | vwde | Von Willebrand factor D and EGF domains. (212 aa) |
| | hspg2 | Heparan sulfate proteoglycan 2. (3462 aa) |
| | cav1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa) |
| | tbxta | T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa) |
| | obscnb | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b. (1660 aa) |
| | anln | Anillin, actin-binding protein. (1171 aa) |
| | pxna | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa) |
| | apobec2b | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2b. (273 aa) |
| | megf10 | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa) |
| | mmp28 | Matrix metallopeptidase 28. (501 aa) |
| | inf2 | GBD/FH3 domain-containing protein. (238 aa) |
| | nphs1 | NPHS1 adhesion molecule, nephrin. (1287 aa) |
