STRINGSTRING
col1a1b col1a1b col1a1a col1a1a prdm1a prdm1a prkci prkci sox9a sox9a gpc4 gpc4 jag1b jag1b gli2a gli2a ube2ib ube2ib plod2 plod2 kcnk5b kcnk5b tbx6 tbx6 wls wls wdr82 wdr82 slc35b2 slc35b2 hes6 hes6 unc45b unc45b ewsr1a ewsr1a tgfb3 tgfb3 pes pes foxl1 foxl1 itga5 itga5 sec61a1 sec61a1 gpr137ba gpr137ba acvrl1 acvrl1 rarab rarab xpr1b xpr1b pitx2 pitx2 tshr tshr pold1 pold1 emx2 emx2 dcaf7 dcaf7 itga8 itga8 shoc2 shoc2 ift172 ift172 sox9b sox9b abcc6a abcc6a gcm2 gcm2 dstyk dstyk aldh1a2 aldh1a2 pax9 pax9 ngs ngs ptch2 ptch2 cmn cmn uxs1 uxs1 ext2 ext2 ndst1a ndst1a furina furina ptk7a ptk7a col2a1a col2a1a eda eda col8a1a col8a1a clcn7 clcn7 kif6 kif6 pthlhb pthlhb edn1 edn1 tonsl tonsl acvr2aa acvr2aa meox1 meox1 dlx5a dlx5a rspo2 rspo2 cyp26b1 cyp26b1 foxc1a foxc1a wnt9a wnt9a acvr2ba acvr2ba adrb3b adrb3b tp73 tp73 sp7 sp7 rpz rpz enpp1 enpp1 atp6v1h atp6v1h chd7 chd7 scxa scxa adgrg6 adgrg6 ift80 ift80 col1a2 col1a2 h3f3a h3f3a l1camb l1camb csf1rb csf1rb golgb1 golgb1 fsta fsta extl3 extl3 disc1 disc1 tnnt2a tnnt2a col11a2 col11a2 gli1 gli1 grem2b grem2b slc10a7 slc10a7 fgf3 fgf3 edar edar brpf1 brpf1 foxi1 foxi1 wnt5b wnt5b unc45a unc45a fras1 fras1 hdac4 hdac4 trpm7 trpm7 csf1ra csf1ra bmp1a bmp1a slc39a8 slc39a8 tfap2a tfap2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
col1a1bCollagen, type I, alpha 1b. (1449 aa)
col1a1aCollagen, type I, alpha 1a. (1447 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
prkciProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa)
sox9aHMG box transcription factor Sox9a. (462 aa)
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
ube2ibSUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
plod2Procollagen lysine 2-oxoglutarate 5-dioxygenase 2b isoform. (754 aa)
kcnk5bPotassium channel, subfamily K, member 5b; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (448 aa)
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
wlsWnt ligand secretion mediator. (542 aa)
wdr82WD repeat-containing protein 82; Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus; Belongs to the WD repeat SWD2 family. (313 aa)
slc35b2Solute carrier family 35, member B2. (435 aa)
hes6Hes family bHLH transcription factor 6. (226 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
ewsr1aEWS RNA-binding protein 1a. (626 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
pesPescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa)
foxl1Forkhead transcription factor. (360 aa)
itga5Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1053 aa)
sec61a1Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. (476 aa)
gpr137baG protein-coupled receptor 137Ba; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (By similarity). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Acts also as a negative regulator of osteoclast activity. May be involved in interleukin-4-induced M2 macrophage polarization (By similarity). ECO:0000250|UniProtKB:Q8BNQ3, ; Belo [...] (373 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (499 aa)
rarabRetinoic acid receptor alpha-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins; Belongs to the nuclear hormone receptor family. NR1 subfamily. (458 aa)
xpr1bXenotropic and polytropic retrovirus receptor 1 homolog; Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho- inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (By similarity). (693 aa)
pitx2Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa)
tshrThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (757 aa)
pold1DNA polymerase. (1105 aa)
emx2Empty spiracles homeobox 2. (247 aa)
dcaf7Ddb1 and cul4-associated factor 7. (342 aa)
itga8Integrin, alpha 8; Belongs to the integrin alpha chain family. (1059 aa)
shoc2Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and stimulate raf1 activity at specialized signaling complexes (By similarity). (561 aa)
ift172Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
abcc6aATP-binding cassette, sub-family C (CFTR/MRP), member 6a. (1507 aa)
gcm2Glial cells missing homolog 2 (Drosophila). (496 aa)
dstykDual serine/threonine and tyrosine protein kinase; May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death (By similarity). Plays a role in the embryonic development. (857 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
pax9Paired box 9. (343 aa)
ngsNotochord granular surface; Belongs to the intermediate filament family. (539 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
cmnCalymmin. (1207 aa)
uxs1UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Essential during embryogenesis for craniofacial development. Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (418 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
ndst1aN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a. (869 aa)
furinaFurin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (806 aa)
ptk7aProtein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa)
col2a1aCollagen, type II, alpha 1a. (1491 aa)
edaEctodysplasin A; Belongs to the tumor necrosis factor family. (359 aa)
col8a1aCollagen, type VIII, alpha 1a. (711 aa)
clcn7Chloride channel protein. (795 aa)
kif6Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (761 aa)
pthlhbParathyroid hormone-related peptide 2. (162 aa)
edn1Endothelin 1. (188 aa)
tonslTonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks; Belongs to the Tonsoku family. (1427 aa)
acvr2aaSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (538 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
dlx5aHomeobox protein Dlx5a; Belongs to the distal-less homeobox family. (282 aa)
rspo2R-spondin 2_variant1. (248 aa)
cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa)
foxc1aForkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa)
wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
acvr2baSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
adrb3bBeta-3-adrenergic receptor b; Belongs to the G-protein coupled receptor 1 family. (405 aa)
tp73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (640 aa)
sp7Sp7 transcription factor. (528 aa)
rpzProtein rapunzel. (227 aa)
enpp1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
atp6v1hV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (481 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
scxaScleraxis bHLH transcription factor a. (199 aa)
adgrg6Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development. (1240 aa)
ift80Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa)
col1a2Collagen, type I, alpha 2. (1352 aa)
h3f3aH3 histone, family 3B.1. (136 aa)
l1cambNeural cell adhesion molecule L1.1; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1332 aa)
csf1rbColony-stimulating factor 1 receptor, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
golgb1Golgin B1. (3355 aa)
fstaFollistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa)
extl3Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (917 aa)
disc1DISC1 scaffold protein. (994 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
col11a2Collagen, type XI, alpha 2. (1803 aa)
gli1GLI family zinc finger 1. (1404 aa)
grem2bGremlin. (166 aa)
slc10a7Sodium/bile acid cotransporter 7; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix (By similarity). Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates. (336 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
edarEctodysplasin A receptor. (460 aa)
brpf1Bromodomain and PHD finger-containing, 1. (1248 aa)
foxi1Forkhead box I1. (377 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
unc45aUnc-45 myosin chaperone A. (935 aa)
fras1Fraser extracellular matrix complex subunit 1. (4003 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
trpm7Transient receptor potential cation channel, subfamily M, member 7. (1787 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
bmp1aMetalloendopeptidase. (986 aa)
slc39a8Solute carrier family 39 member 8. (198 aa)
tfap2aTranscription factor AP-2 alpha. (450 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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