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| | esco2 | N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development. (609 aa) |
| | mmp2 | Matrix metalloproteinase 2. (657 aa) |
| | sec63 | SEC63 homolog, protein translocation regulator. (751 aa) |
| | kif11 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1062 aa) |
| | degs1 | Delta(4)-desaturase, sphingolipid 1. (323 aa) |
| | erbb2 | Receptor protein-tyrosine kinase. (1275 aa) |
| | ptf1a | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. (265 aa) |
| | dla | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] (772 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | fat1b | FAT atypical cadherin 1b. (4503 aa) |
| | gli2b | GLI family zinc finger 2b. (1225 aa) |
| | smn1 | Survival motor neuron protein 1; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites. (281 aa) |
| | snx5 | Sorting nexin; Involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. (399 aa) |
| | mmp14a | Matrix metallopeptidase 14a (membrane-inserted). (574 aa) |
| | sfpq | Splicing factor proline/glutamine-rich. (638 aa) |
| | ptch1 | Protein patched homolog 1. (1475 aa) |
| | rbpja | Recombination signal-binding protein for immunoglobulin kappa J region a. (496 aa) |
| | pes | Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa) |
| | slitrk2 | SLIT and NTRK-like family, member 2. (854 aa) |
| | itga5 | Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1053 aa) |
| | eftud2 | Elongation factor Tu GTP-binding domain-containing 2. (973 aa) |
| | epha4b | Eph receptor A4b. (976 aa) |
| | vsx2 | Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. (372 aa) |
| | itgb1a | Integrin beta; Belongs to the integrin beta chain family. (798 aa) |
| | xirp1 | Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization. Belongs to the Xin family. (2297 aa) |
| | dctn2 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). (405 aa) |
| | mpp6b | Membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6); Belongs to the MAGUK family. (539 aa) |
| | gmds | GDP-mannose 4,6 dehydratase. (370 aa) |
| | enpp2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2. (850 aa) |
| | copa | Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1224 aa) |
| | kif1b | Kinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1770 aa) |
| | vps11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa) |
| | egr1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa) |
| | cln3 | Battenin. (446 aa) |
| | etfdh | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (617 aa) |
| | lamb4 | Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1827 aa) |
| | utp11 | U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (250 aa) |
| | olig2 | Oligodendrocyte lineage transcription factor 2. (273 aa) |
| | myo6b | Myosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1267 aa) |
| | cadm1b | Cell adhesion molecule 1b. (370 aa) |
| | nphp1 | Nephronophthisis 1. (667 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | bace2 | Zgc:103530 protein; Belongs to the peptidase A1 family. (372 aa) |
| | spg11 | SPG11 vesicle-trafficking-associated, spatacsin. (1612 aa) |
| | gdf6a | Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) |
| | id2a | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a. (137 aa) |
| | leo1 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. (696 aa) |
| | wnt1 | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa) |
| | ihhb | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa) |
| | tgif1 | TGFB-induced factor homeobox 1. (273 aa) |
| | ranbp9 | Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. (597 aa) |
| | tfpi2 | Tissue factor pathway inhibitor. (233 aa) |
| | sypb | Synaptophysin b. (297 aa) |
| | kifbp | KIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. (631 aa) |
| | cadm2b | Cell adhesion molecule 2b. (381 aa) |
| | actr10 | Actin-related protein 10; Belongs to the actin family. (415 aa) |
| | swap70b | Switching B cell complex subunit SWAP70b. (588 aa) |
| | abhd11 | Protein ABHD11; Belongs to the AB hydrolase superfamily. (317 aa) |
| | timp2b | TIMP metallopeptidase inhibitor 2b. (265 aa) |
| | itga6b | Integrin, alpha 6b; Belongs to the integrin alpha chain family. (1085 aa) |
| | tuba8l3 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa) |
| | stat3 | Signal transducer and activator of transcription. (806 aa) |
| | abhd12 | Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase act [...] (382 aa) |
| | nav1b | Neuron navigator 1b. (1790 aa) |
| | boc | BOC cell adhesion-associated, oncogene-regulated. (1032 aa) |
| | mak16 | Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa) |
| | sox10 | HMG-box transcription factor Sox10. (485 aa) |
| | abcd1 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination. (766 aa) |
| | cdhr1a | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. (857 aa) |
| | apcdd1l | Adenomatosis polyposis coli down-regulated 1-like. (512 aa) |
| | dtx4a | Deltex 4, E3 ubiquitin ligase a. (704 aa) |
| | twistnb | DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity). (390 aa) |
| | erbb3b | Erb-b2 receptor tyrosine kinase 3b. (1429 aa) |
| | mtor | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa) |
| | prmt6 | Protein arginine N-methyltransferase 6; Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on [...] (355 aa) |
| | ptena | Phosphatase and tensin homolog A; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (467 aa) |
| | csnk1a1 | Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (365 aa) |
| | foxd3 | Forkhead box D3. (371 aa) |
| | pard3ab | Par-3 family cell polarity regulator alpha, b. (1332 aa) |
| | gnl3 | Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa) |
| | gle1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa) |
| | nes | Nestin; Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Required for brain and eye development. (1265 aa) |
| | fbxw7 | F-box and WD repeat domain-containing 7. (544 aa) |
| | cadm4 | Cell adhesion molecule 4. (413 aa) |
| | dcaf8 | DDB1 and CUL4-associated factor 8. (607 aa) |
| | chd7 | Chromodomain helicase DNA-binding protein 7. (3140 aa) |
| | vwc2 | Von Willebrand factor C domain-containing 2. (309 aa) |
| | cadm1a | Cell adhesion molecule 1a. (447 aa) |
| | ppp1r12a | Protein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa) |
| | snx19a | Sorting nexin 19a. (883 aa) |
| | cux2b | Homeobox protein cut-like. (1356 aa) |
| | il7r | Interleukin 7 receptor. (372 aa) |
| | icn2 | Protein S100; Belongs to the S-100 family. (97 aa) |
| | l1camb | Neural cell adhesion molecule L1.1; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1332 aa) |
| | wt1b | WT1 transcription factor b. (412 aa) |
| | epb41l5 | Erythrocyte membrane protein band 4.1-like 5. (461 aa) |
| | lamb2 | Laminin, beta 2 (laminin S). (1782 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | kirrel1a | Kirre-like nephrin family adhesion molecule 1a. (807 aa) |
| | kmt2a | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4218 aa) |
| | epha4a | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa) |
| | apobec2a | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2a. (266 aa) |
| | hepacama | Hepatic and glial cell adhesion molecule a. (451 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | syne2a | Si:ch211-207i1.2. (8864 aa) |
| | kcnj13 | Potassium inwardly rectifying channel subfamily J member 13. (362 aa) |
| | map1ab | Microtubule-associated protein 1Ab. (3737 aa) |
| | sptbn5 | Spectrin, beta, non-erythrocytic 5. (4140 aa) |
| | prnprs3 | Prion protein,-related sequence 3. (559 aa) |
| | cdc73 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa) |
| | f8 | Coagulation factor VIII, procoagulant component. (1674 aa) |
| | nrg1 | Neuregulin 1. (730 aa) |
| | lamb1a | Laminin, beta 1a. (1785 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | cacnb2a | Calcium channel, voltage-dependent, beta 2a. (636 aa) |
| | nfat5b | Nuclear factor of-activated T cells 5b. (1257 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | bmp5 | Bone morphogenetic protein 5. (446 aa) |
| | radil | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. (1124 aa) |
| | rest | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa) |
| | arnt2 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor. (737 aa) |
| | hmgcs1 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa) |
| | irx1a | Iroquois homeobox protein 1, a. (426 aa) |
| | dock1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1840 aa) |
| | dync1h1 | Dynein, cytoplasmic 1, heavy chain 1. (1765 aa) |
| | pde6c | Phosphodiesterase. (852 aa) |
| | adgrg1 | Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (648 aa) |
| | ep300a | E1A-binding protein p300 a. (2679 aa) |
| | vwde | Von Willebrand factor D and EGF domains. (212 aa) |
| | gnl2 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (726 aa) |
| | etfa | Electron-transfer-flavoprotein, alpha polypeptide. (333 aa) |
| | znf16l | Zinc finger protein 16-like; Probable transcription factor (Probable). Important for development and migration of oligodendrocyte precursor cells, and normal myelination of axons in the central nervous system (CNS). Functions autonomously in oligodendrocytes to promote CNS myelination. Seems to act in parallel with notch3 during oligodendrocyte development. Belongs to the krueppel C2H2-type zinc-finger protein family. (528 aa) |
| | rnaset2 | Ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA. (240 aa) |
| | Reln | Reelin domain-containing protein. (259 aa) |
| | dctn1a | Dynactin 1a. (1257 aa) |
| | apobec2b | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2b. (273 aa) |
| | rraga | Ras-related GTP-binding A. (316 aa) |
| | mmp28 | Matrix metallopeptidase 28. (501 aa) |
| | nkx2.2a | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa) |
| | nphs1 | NPHS1 adhesion molecule, nephrin. (1287 aa) |
| | tfeb | Transcription factor EB. (493 aa) |
