STRINGSTRING
rnf2 rnf2 col1a1a col1a1a prdm1a prdm1a sox9a sox9a gpc4 gpc4 fgf20a fgf20a jag1b jag1b smo smo kcnk5b kcnk5b wls wls fgf8a fgf8a slc35b2 slc35b2 hand2 hand2 ewsr1a ewsr1a ptch1 ptch1 tgfb3 tgfb3 panx3 panx3 tbx5a tbx5a fgf10a fgf10a hoxa13b hoxa13b polr1d polr1d emx2 emx2 prkcz prkcz sox9b sox9b pax9 pax9 atp2b1a atp2b1a uxs1 uxs1 ext2 ext2 ihha ihha hhip hhip kat2b kat2b furina furina plcb3 plcb3 mef2ca mef2ca eda eda dll4 dll4 skib skib clcn7 clcn7 edn1 edn1 acvr2aa acvr2aa meox1 meox1 ahr2 ahr2 ids ids gba gba rspo2 rspo2 cyp26b1 cyp26b1 gnptab gnptab acvr2ba acvr2ba sp7 sp7 polr1c polr1c notch2 notch2 enpp1 enpp1 lef1 lef1 scxa scxa pth1a pth1a sbds sbds tgfb2 tgfb2 b3gat3 b3gat3 shha shha col11a2 col11a2 ostn ostn nomo nomo grem2b grem2b slc10a7 slc10a7 edar edar brpf1 brpf1 hoxa13a hoxa13a sox32 sox32 col22a1 col22a1 hdac4 hdac4 pdlim7 pdlim7 evx1 evx1 trpm7 trpm7 bmp1a bmp1a kat2a kat2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rnf2E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa)
col1a1aCollagen, type I, alpha 1a. (1447 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
sox9aHMG box transcription factor Sox9a. (462 aa)
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
fgf20aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
kcnk5bPotassium channel, subfamily K, member 5b; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (448 aa)
wlsWnt ligand secretion mediator. (542 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
slc35b2Solute carrier family 35, member B2. (435 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
ewsr1aEWS RNA-binding protein 1a. (626 aa)
ptch1Protein patched homolog 1. (1475 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
panx3Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (444 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
fgf10aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
hoxa13bHomeobox protein Hox-A13b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (289 aa)
polr1dDNA-directed RNA polymerases I and III subunit RPAC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). (112 aa)
emx2Empty spiracles homeobox 2. (247 aa)
prkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
pax9Paired box 9. (343 aa)
atp2b1aCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1228 aa)
uxs1UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Essential during embryogenesis for craniofacial development. Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (418 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
hhipHedgehog-interacting protein. (693 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
furinaFurin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (806 aa)
plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1244 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
edaEctodysplasin A; Belongs to the tumor necrosis factor family. (359 aa)
dll4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (683 aa)
skibV-ski avian sarcoma viral oncogene homolog b. (695 aa)
clcn7Chloride channel protein. (795 aa)
edn1Endothelin 1. (188 aa)
acvr2aaSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (538 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
ahr2Aryl hydrocarbon receptor 2. (1027 aa)
idsIduronate 2-sulfatase. (561 aa)
gbaGlucosylceramidase. (518 aa)
rspo2R-spondin 2_variant1. (248 aa)
cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa)
gnptabN-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. (1219 aa)
acvr2baSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
sp7Sp7 transcription factor. (528 aa)
polr1cRNA polymerase I and III subunit C. (362 aa)
notch2Notch receptor 2. (2475 aa)
enpp1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
scxaScleraxis bHLH transcription factor a. (199 aa)
pth1aParathyroid hormone 1a. (102 aa)
sbdsSBDS ribosome maturation factor. (250 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
b3gat3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (330 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
col11a2Collagen, type XI, alpha 2. (1803 aa)
ostnOsteocrin. (134 aa)
nomoNodal modulator. (1208 aa)
grem2bGremlin. (166 aa)
slc10a7Sodium/bile acid cotransporter 7; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix (By similarity). Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates. (336 aa)
edarEctodysplasin A receptor. (460 aa)
brpf1Bromodomain and PHD finger-containing, 1. (1248 aa)
hoxa13aHomeobox protein Hox-A13a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (310 aa)
sox32SRY-box transcription factor 32. (307 aa)
col22a1Collagen, type XXII, alpha 1. (1622 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
pdlim7PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity). (419 aa)
evx1Even-skipped homeobox 1. (377 aa)
trpm7Transient receptor potential cation channel, subfamily M, member 7. (1787 aa)
bmp1aMetalloendopeptidase. (986 aa)
kat2aHistone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for [...] (819 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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