STRINGSTRING
thraa thraa usb1 usb1 ugdh ugdh prdm1a prdm1a sox9a sox9a mbtps1 mbtps1 gli2a gli2a smo smo nkx2.5 nkx2.5 mafba mafba fgf8a fgf8a mkks mkks c19h1orf109 c19h1orf109 nup88 nup88 tbx1 tbx1 rps19 rps19 rarga rarga atp6v1e1b atp6v1e1b hdac1 hdac1 smad5 smad5 egr1 egr1 atoh8 atoh8 wnt9b wnt9b gdf3 gdf3 pold1 pold1 arl6ip1 arl6ip1 vgll2a vgll2a disp1 disp1 cax1 cax1 cnbpa cnbpa stra6 stra6 htt htt aldh1a2 aldh1a2 sec13 sec13 tm4sf5 tm4sf5 ext2 ext2 chaf1b chaf1b ptpn11a ptpn11a gpatch3 gpatch3 kat2b kat2b polr3b polr3b wnt3a wnt3a yap1 yap1 dmrt2b dmrt2b crip2 crip2 edn1 edn1 ids ids ocrl ocrl polr1b polr1b cyp26b1 cyp26b1 birc5a birc5a rerea rerea pappa2 pappa2 wnt9a wnt9a zcchc7 zcchc7 foxd3 foxd3 myf5 myf5 pknox1.2 pknox1.2 polr1c polr1c chd7 chd7 eif2ak3 eif2ak3 extl3 extl3 b3gat3 b3gat3 mych mych ep300b ep300b polr1a polr1a ptpn12 ptpn12 fgf3 fgf3 mib1 mib1 mcm2 mcm2 hmgcrb hmgcrb sufu sufu foxi1 foxi1 rtn4b rtn4b sox32 sox32 ep300a ep300a ttc8 ttc8 smarca4a smarca4a esrra esrra phf8 phf8 kat2a kat2a tfap2a tfap2a
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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thraaThyroid hormone receptor alpha-A; High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (427 aa)
usb1U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (276 aa)
ugdhUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (493 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
sox9aHMG box transcription factor Sox9a. (462 aa)
mbtps1Membrane-bound transcription factor peptidase, site 1. (1074 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
nkx2.5NK2 homeobox 5. (314 aa)
mafbaTranscription factor MafB; May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. Belongs to the bZIP family. Maf subfamily. (397 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
mkksMcKusick-Kaufman syndrome. (563 aa)
c19h1orf109Uncharacterized protein C1orf109 homolog; Plays an essential role in early embryonic development. (218 aa)
nup88Nucleoporin 88; Component of the nuclear pore complex. (720 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
rps19Ribosomal protein S19. (146 aa)
rargaRetinoic acid receptor gamma-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches; Belongs to the nuclear hormone receptor family. NR1 subfamily. (499 aa)
atp6v1e1bATPase H+-transporting V1 subunit E1b. (226 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
egr1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa)
atoh8Protein atonal homolog 8; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). During development, is required for heart looping and swim bladder formation by acting in concert with GATA4 AND ZFPM1. During the development of both the retina and skeletal muscles is required for neural retinal cell through modulating PAX6 and NEUROG3 expression and myogenic differentiation. (266 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
gdf3Protein DVR-1; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. (355 aa)
pold1DNA polymerase. (1105 aa)
arl6ip1ADP-ribosylation factor-like 6-interacting protein 1. (203 aa)
vgll2aVestigial-like family member 2a. (296 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
cax1Type II CAX cation/proton exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (764 aa)
cnbpaCCHC-type zinc finger, nucleic acid-binding protein a. (163 aa)
stra6Receptor for retinol uptake stra6; Retinol transporter. Accepts retinol from the extracellular retinol-binding protein rbp4, mediates retinol transport across the cell membrane, and then transmits retinol to the cytoplasmic retinol- binding protein rbp1. Required for normal vitamin A homeostasis. (670 aa)
httHuntingtin. (3121 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
sec13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
tm4sf5Transmembrane 4 L six family member 5. (201 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
chaf1bChromatin assembly factor 1, subunit B. (613 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
gpatch3G patch domain-containing 3. (669 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
polr3bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1130 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
dmrt2bDoublesex and mab-3-related transcription factor 2b. (364 aa)
crip2Cysteine-rich protein 2. (206 aa)
edn1Endothelin 1. (188 aa)
idsIduronate 2-sulfatase. (561 aa)
ocrlOCRL inositol polyphosphate-5-phosphatase. (953 aa)
polr1bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1132 aa)
cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa)
birc5aBaculoviral IAP repeat-containing 5a. (190 aa)
rereaArginine-glutamic acid dipeptide (RE) repeats a. (1531 aa)
pappa2Pappalysin 2. (1731 aa)
wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
zcchc7Zinc finger, CCHC domain-containing 7. (627 aa)
foxd3Forkhead box D3. (371 aa)
myf5Myogenic factor. (237 aa)
pknox1.2Pbx/knotted 1 homeobox 1.2. (445 aa)
polr1cRNA polymerase I and III subunit C. (362 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa)
extl3Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (917 aa)
b3gat3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (330 aa)
mychTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (360 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
polr1aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1693 aa)
ptpn12Protein tyrosine phosphatase non-receptor type 12. (170 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
mcm2DNA helicase; Belongs to the MCM family. (889 aa)
hmgcrb3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa)
sufuSuppressor of fused homolog. (485 aa)
foxi1Forkhead box I1. (377 aa)
rtn4bReticulon. (876 aa)
sox32SRY-box transcription factor 32. (307 aa)
ep300aE1A-binding protein p300 a. (2679 aa)
ttc8Tetratricopeptide repeat domain 8. (268 aa)
smarca4aSWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4a. (1627 aa)
esrraEstrogen-related receptor alpha. (436 aa)
phf8Histone lysine demethylase PHF8; Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys- 20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivato [...] (1032 aa)
kat2aHistone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for [...] (819 aa)
tfap2aTranscription factor AP-2 alpha. (450 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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