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| | esco2 | N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development. (609 aa) |
| | mmp2 | Matrix metalloproteinase 2. (657 aa) |
| | ptf1a | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. (265 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | fat1b | FAT atypical cadherin 1b. (4503 aa) |
| | gli2b | GLI family zinc finger 2b. (1225 aa) |
| | snx5 | Sorting nexin; Involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. (399 aa) |
| | mmp14a | Matrix metallopeptidase 14a (membrane-inserted). (574 aa) |
| | sfpq | Splicing factor proline/glutamine-rich. (638 aa) |
| | ptch1 | Protein patched homolog 1. (1475 aa) |
| | rbpja | Recombination signal-binding protein for immunoglobulin kappa J region a. (496 aa) |
| | pes | Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa) |
| | slitrk2 | SLIT and NTRK-like family, member 2. (854 aa) |
| | itga5 | Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1053 aa) |
| | vsx2 | Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. (372 aa) |
| | itgb1a | Integrin beta; Belongs to the integrin beta chain family. (798 aa) |
| | xirp1 | Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization. Belongs to the Xin family. (2297 aa) |
| | dctn2 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). (405 aa) |
| | mpp6b | Membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6); Belongs to the MAGUK family. (539 aa) |
| | vps11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa) |
| | egr1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa) |
| | cln3 | Battenin. (446 aa) |
| | lamb4 | Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1827 aa) |
| | utp11 | U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (250 aa) |
| | myo6b | Myosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1267 aa) |
| | cadm1b | Cell adhesion molecule 1b. (370 aa) |
| | nphp1 | Nephronophthisis 1. (667 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | gdf6a | Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) |
| | id2a | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a. (137 aa) |
| | tgif1 | TGFB-induced factor homeobox 1. (273 aa) |
| | ranbp9 | Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. (597 aa) |
| | sypb | Synaptophysin b. (297 aa) |
| | cadm2b | Cell adhesion molecule 2b. (381 aa) |
| | abhd11 | Protein ABHD11; Belongs to the AB hydrolase superfamily. (317 aa) |
| | timp2b | TIMP metallopeptidase inhibitor 2b. (265 aa) |
| | itga6b | Integrin, alpha 6b; Belongs to the integrin alpha chain family. (1085 aa) |
| | stat3 | Signal transducer and activator of transcription. (806 aa) |
| | nav1b | Neuron navigator 1b. (1790 aa) |
| | mak16 | Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa) |
| | sox10 | HMG-box transcription factor Sox10. (485 aa) |
| | cdhr1a | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. (857 aa) |
| | apcdd1l | Adenomatosis polyposis coli down-regulated 1-like. (512 aa) |
| | twistnb | DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity). (390 aa) |
| | prmt6 | Protein arginine N-methyltransferase 6; Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on [...] (355 aa) |
| | csnk1a1 | Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (365 aa) |
| | gnl3 | Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa) |
| | cadm4 | Cell adhesion molecule 4. (413 aa) |
| | dcaf8 | DDB1 and CUL4-associated factor 8. (607 aa) |
| | vwc2 | Von Willebrand factor C domain-containing 2. (309 aa) |
| | cadm1a | Cell adhesion molecule 1a. (447 aa) |
| | ppp1r12a | Protein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa) |
| | snx19a | Sorting nexin 19a. (883 aa) |
| | cux2b | Homeobox protein cut-like. (1356 aa) |
| | icn2 | Protein S100; Belongs to the S-100 family. (97 aa) |
| | wt1b | WT1 transcription factor b. (412 aa) |
| | epb41l5 | Erythrocyte membrane protein band 4.1-like 5. (461 aa) |
| | lamb2 | Laminin, beta 2 (laminin S). (1782 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | kirrel1a | Kirre-like nephrin family adhesion molecule 1a. (807 aa) |
| | kmt2a | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4218 aa) |
| | apobec2a | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2a. (266 aa) |
| | hepacama | Hepatic and glial cell adhesion molecule a. (451 aa) |
| | syne2a | Si:ch211-207i1.2. (8864 aa) |
| | kcnj13 | Potassium inwardly rectifying channel subfamily J member 13. (362 aa) |
| | map1ab | Microtubule-associated protein 1Ab. (3737 aa) |
| | sptbn5 | Spectrin, beta, non-erythrocytic 5. (4140 aa) |
| | f8 | Coagulation factor VIII, procoagulant component. (1674 aa) |
| | lamb1a | Laminin, beta 1a. (1785 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | cacnb2a | Calcium channel, voltage-dependent, beta 2a. (636 aa) |
| | nfat5b | Nuclear factor of-activated T cells 5b. (1257 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | irx1a | Iroquois homeobox protein 1, a. (426 aa) |
| | pde6c | Phosphodiesterase. (852 aa) |
| | vwde | Von Willebrand factor D and EGF domains. (212 aa) |
| | gnl2 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (726 aa) |
| | rnaset2 | Ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA. (240 aa) |
| | Reln | Reelin domain-containing protein. (259 aa) |
| | dctn1a | Dynactin 1a. (1257 aa) |
| | apobec2b | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2b. (273 aa) |
| | mmp28 | Matrix metallopeptidase 28. (501 aa) |
| | nphs1 | NPHS1 adhesion molecule, nephrin. (1287 aa) |
