STRINGSTRING
bysl bysl tbx16 tbx16 sirt2 sirt2 cdh2 cdh2 hif1ab hif1ab prkci prkci rpl5a rpl5a kif11 kif11 dkc1 dkc1 gpr183a gpr183a ube2ib ube2ib isl1 isl1 dnmt1 dnmt1 smo smo sae1 sae1 smyd5 smyd5 pdcd2 pdcd2 mafba mafba dlc dlc isl2a isl2a racgap1 racgap1 ptgs2a ptgs2a foxf1 foxf1 ism1 ism1 efnb1 efnb1 ptch1 ptch1 tnfa tnfa snrkb snrkb naca naca pes pes g6pc3 g6pc3 eftud2 eftud2 glra4a glra4a klf6a klf6a adtrp1 adtrp1 tbx1 tbx1 iqsec1b iqsec1b fbxw4 fbxw4 cdk10 cdk10 etv2 etv2 itga9 itga9 fgf10a fgf10a rps19 rps19 ddx18 ddx18 kdr kdr notch1b notch1b ncor2 ncor2 hdac1 hdac1 cdkn2aip cdkn2aip smox smox snrnp70 snrnp70 socs1a socs1a sfrp5 sfrp5 utp11 utp11 pttg1ipb pttg1ipb snai2 snai2 rps29 rps29 rad51 rad51 selp selp supt5h supt5h pou5f3 pou5f3 fzd8a fzd8a col4a5 col4a5 notch3 notch3 tbl3 tbl3 htt htt myb myb prox1a prox1a neurog1 neurog1 sf3b1 sf3b1 hdac9b hdac9b epas1b epas1b stc1l stc1l myef2 myef2 tal1 tal1 sdc4 sdc4 camsap2b camsap2b ogg1 ogg1 f2r f2r ptger3 ptger3 kdm1a kdm1a lrsam1 lrsam1 trim69 trim69 march2 march2 jam3b jam3b stab1 stab1 IQSEC1 IQSEC1 dld dld swap70b swap70b vegfc vegfc ptger4a ptger4a dll4 dll4 hey1 hey1 vhl vhl fezf2 fezf2 hmx3a hmx3a zdhhc15b zdhhc15b gba gba mak16 mak16 birc5a birc5a kri1 kri1 ifngr1 ifngr1 dtx4a dtx4a mettl22 mettl22 twistnb twistnb ptgs1 ptgs1 tnfrsf1b tnfrsf1b hoxc9a hoxc9a wnt9a wnt9a emilin1a emilin1a ccbe1 ccbe1 prdm16 prdm16 etv5a etv5a junba junba mecp2 mecp2 gnl3 gnl3 gle1 gle1 ecscr ecscr max max runx1 runx1 ptger2a ptger2a fbxw7 fbxw7 myo6a myo6a adora2b adora2b sox18 sox18 chd7 chd7 rap1b rap1b hlx1 hlx1 stab2 stab2 tmem88a tmem88a ppp1r12a ppp1r12a plcg1 plcg1 jag1a jag1a urb2 urb2 birc5b birc5b bloc1s2 bloc1s2 tgfb1b tgfb1b wnt16 wnt16 ifng1 ifng1 epb41l5 epb41l5 wdr43 wdr43 tnnt2a tnnt2a nrp2a nrp2a clocka clocka nova2 nova2 ap2a1 ap2a1 znf644b znf644b cpsf1 cpsf1 lrp2a lrp2a akt1 akt1 lamb1a lamb1a znf644a znf644a junbb junbb mib1 mib1 nop10 nop10 nedd4a nedd4a sufu sufu flt4 flt4 foxi1 foxi1 gipc1 gipc1 wnt5b wnt5b ddx46 ddx46 nos1 nos1 rspo1 rspo1 arnt2 arnt2 cxcl8a cxcl8a metap2b metap2b tfec tfec nop14 nop14 sf3a3 sf3a3 etfa etfa hal hal arap3 arap3 svep1 svep1 iqcg iqcg gfi1b gfi1b aggf1 aggf1 stat4 stat4 tcf7l1b tcf7l1b npas4l npas4l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
byslBystin-like. (466 aa)
tbx16T-box transcription factor 16. (470 aa)
sirt2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] (379 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
prkciProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa)
rpl5aRibosomal protein L5a. (297 aa)
kif11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1062 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (506 aa)
gpr183aG-protein coupled receptor 183-A; G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses [...] (368 aa)
ube2ibSUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
sae1SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. (348 aa)
smyd5SMYD family member 5. (415 aa)
pdcd2Programmed cell death 2. (358 aa)
mafbaTranscription factor MafB; May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. Belongs to the bZIP family. Maf subfamily. (397 aa)
dlcDelta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (664 aa)
isl2aInsulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. (359 aa)
racgap1Rac GTPase-activating protein 1. (654 aa)
ptgs2aProstaglandin-endoperoxide synthase 2a. (601 aa)
foxf1Forkhead box protein F1. (380 aa)
ism1Isthmin-1; May specifically influence certain angiogenesis process. (461 aa)
efnb1Ephrin-B1; Belongs to the ephrin family. (341 aa)
ptch1Protein patched homolog 1. (1475 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
snrkbSNF-related kinase b. (741 aa)
nacaNascent polypeptide-associated complex subunit alpha; May promote appropriate targeting of ribosome-nascent polypeptide complexes. (215 aa)
pesPescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa)
g6pc3Glucose-6-phosphatase 3; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity); Belongs to the glucose-6-phosphatase family. (339 aa)
eftud2Elongation factor Tu GTP-binding domain-containing 2. (973 aa)
glra4aGlycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
klf6aKruppel-like factor 6a. (283 aa)
adtrp1Androgen-dependent TFPI-regulating protein 1. (242 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
iqsec1bIQ motif and Sec7 domain ArfGEF 1b. (1252 aa)
fbxw4F-box and WD repeat domain-containing 4. (392 aa)
cdk10Cyclin-dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa)
etv2ETS variant transcription factor 2. (366 aa)
itga9Integrin, alpha 9; Belongs to the integrin alpha chain family. (1032 aa)
fgf10aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
rps19Ribosomal protein S19. (146 aa)
ddx18RNA helicase. (653 aa)
kdrVascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa)
notch1bNotch receptor 1b. (2465 aa)
ncor2Nuclear receptor corepressor 2. (2315 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
cdkn2aipCDKN2A-interacting protein. (312 aa)
smoxSpermine oxidase. (539 aa)
snrnp70Small nuclear ribonucleoprotein 70 (U1). (495 aa)
socs1aSuppressor of cytokine-signaling 1a. (201 aa)
sfrp5Secreted frizzled-related protein 5. (310 aa)
utp11U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (250 aa)
pttg1ipbPituitary tumor-transforming 1 interacting protein. (172 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
rps29Ribosomal protein S29. (56 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
selpSelectin P. (868 aa)
supt5hTranscription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] (1084 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
fzd8aFrizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
col4a5Collagen, type IV, alpha 5 (Alport syndrome). (1679 aa)
notch3Notch receptor 3. (2468 aa)
tbl3Transducin beta-like 3. (897 aa)
httHuntingtin. (3121 aa)
mybV-myb avian myeloblastosis viral oncogene homolog. (641 aa)
prox1aProspero homeobox 1a. (739 aa)
neurog1Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificati [...] (208 aa)
sf3b1Splicing factor 3b, subunit 1. (1315 aa)
hdac9bHistone deacetylase 9-B; Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2- dependent transcription (By similarity). (612 aa)
epas1bEndothelial PAS domain protein 1b. (834 aa)
stc1lStanniocalcin 1,-like. (249 aa)
myef2Myelin expression factor 2. (553 aa)
tal1T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa)
sdc4Syndecan 4. (207 aa)
camsap2bCalmodulin-regulated spectrin-associated protein family, member 2b. (834 aa)
ogg18-oxoguanine DNA glycosylase. (391 aa)
f2rCoagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa)
ptger3Prostaglandin E receptor 3 (subtype EP3). (401 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (833 aa)
lrsam1Leucine-rich repeat and sterile alpha motif-containing 1. (721 aa)
trim69Tripartite motif-containing 69. (548 aa)
march2E3 ubiquitin-protein ligase MARCHF2; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (249 aa)
jam3bJunctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. (333 aa)
stab1Stabilin 1. (2553 aa)
IQSEC1SEC7 domain-containing protein. (953 aa)
dldDelta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (717 aa)
swap70bSwitching B cell complex subunit SWAP70b. (588 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
ptger4aProstaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (403 aa)
dll4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (683 aa)
hey1Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. (317 aa)
vhlVon Hippel-Lindau tumor suppressor. (175 aa)
fezf2Fez family zinc finger protein 2; Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons. (438 aa)
hmx3aHomeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (297 aa)
zdhhc15bPalmitoyltransferase ZDHHC15B; Catalyzes palmitoylation of Cys residues on target proteins. (332 aa)
gbaGlucosylceramidase. (518 aa)
mak16Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa)
birc5aBaculoviral IAP repeat-containing 5a. (190 aa)
kri1Protein KRI1 homolog; Belongs to the KRI1 family. (765 aa)
ifngr1Interferon gamma receptor 1. (394 aa)
dtx4aDeltex 4, E3 ubiquitin ligase a. (704 aa)
mettl22Methyltransferase-like 22. (357 aa)
twistnbDNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity). (390 aa)
ptgs1Prostaglandin-endoperoxide synthase 1. (597 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
hoxc9aHomeobox protein Hox-C9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (270 aa)
wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
emilin1aElastin microfibril interfacer 1a. (1014 aa)
ccbe1Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. (401 aa)
prdm16Si:ch211-263k4.2. (927 aa)
etv5aETS variant transcription factor 5a. (524 aa)
junbaJunB proto-oncogene, AP-1 transcription factor subunit a. (325 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
gnl3Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa)
gle1Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa)
ecscrEndothelial cell surface-expressed chemotaxis and apoptosis regulator. (249 aa)
maxProtein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity). (160 aa)
runx1Runt-related transcription factor. (451 aa)
ptger2aProstaglandin E2 receptor subtype EP2-like; Belongs to the G-protein coupled receptor 1 family. (368 aa)
fbxw7F-box and WD repeat domain-containing 7. (544 aa)
myo6aMyosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1288 aa)
adora2bAdenosine A2b receptor. (351 aa)
sox18SRY-box transcription factor 18. (431 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
rap1bRas-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
hlx1H2.0-like homeo box 1 (Drosophila). (356 aa)
stab2Stabilin 2. (2543 aa)
tmem88aTransmembrane protein 88 a. (219 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
plcg1Phosphoinositide phospholipase C. (1020 aa)
jag1aProtein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa)
urb2URB2 ribosome biogenesis homolog. (1495 aa)
birc5bBaculoviral IAP repeat-containing 5b. (144 aa)
bloc1s2Biogenesis of lysosomal organelles complex-1, subunit 2. (177 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
ifng1Interferon gamma 1. (179 aa)
epb41l5Erythrocyte membrane protein band 4.1-like 5. (461 aa)
wdr43WD repeat domain 43. (650 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
nrp2aNeuropilin; Belongs to the neuropilin family. (927 aa)
clockaClock circadian regulator a. (892 aa)
nova2NOVA alternative-splicing regulator 2. (517 aa)
ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa)
znf644bZinc finger protein 644b. (1267 aa)
cpsf1Cleavage and polyadenylation-specific factor 1. (1451 aa)
lrp2aLow density lipoprotein receptor-related protein 2a. (4673 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
lamb1aLaminin, beta 1a. (1785 aa)
znf644aZinc finger protein 644a. (1169 aa)
junbbJunB proto-oncogene, AP-1 transcription factor subunit b. (310 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
nop10H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (64 aa)
nedd4aE3 ubiquitin-protein ligase. (787 aa)
sufuSuppressor of fused homolog. (485 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
foxi1Forkhead box I1. (377 aa)
gipc1Regulator of G-protein signaling 19-interacting protein 1. (335 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
ddx46Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1018 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
rspo1R-spondin-1; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Belongs to the R-spondin family. (261 aa)
arnt2Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor. (737 aa)
cxcl8aInterleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
metap2bMethionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (476 aa)
tfecTranscription factor EC. (396 aa)
nop14NOP14 nucleolar protein homolog (yeast). (767 aa)
sf3a3Splicing factor 3a, subunit 3. (501 aa)
etfaElectron-transfer-flavoprotein, alpha polypeptide. (333 aa)
halHistidine ammonia-lyase; Belongs to the PAL/histidase family. (654 aa)
arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1664 aa)
svep1Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1. (3615 aa)
iqcgDynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (camk4) activity; contributes to the regulation of camk4 signaling cascades. Plays a role in the regulation of definitive hematopoiesis via its effects on camk4. Belo [...] (346 aa)
gfi1bGrowth factor-independent 1B transcription repressor. (334 aa)
aggf1Angiogenic factor with G patch and FHA domains 1. (775 aa)
stat4Signal transducer and activator of transcription. (741 aa)
tcf7l1bTranscription factor 7-like 1-B; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Also required for hindbrain morphogenesis. Belongs to the TCF/LEF family. (585 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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