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| | bysl | Bystin-like. (466 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | sirt2 | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] (379 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | hif1ab | Hypoxia-inducible factor 1 subunit alpha b. (777 aa) |
| | prkci | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa) |
| | rpl5a | Ribosomal protein L5a. (297 aa) |
| | kif11 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1062 aa) |
| | dkc1 | Dyskeratosis congenita 1, dyskerin. (506 aa) |
| | gpr183a | G-protein coupled receptor 183-A; G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses [...] (368 aa) |
| | ube2ib | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | isl1 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa) |
| | dnmt1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | sae1 | SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. (348 aa) |
| | smyd5 | SMYD family member 5. (415 aa) |
| | pdcd2 | Programmed cell death 2. (358 aa) |
| | mafba | Transcription factor MafB; May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. Belongs to the bZIP family. Maf subfamily. (397 aa) |
| | dlc | Delta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (664 aa) |
| | isl2a | Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. (359 aa) |
| | racgap1 | Rac GTPase-activating protein 1. (654 aa) |
| | ptgs2a | Prostaglandin-endoperoxide synthase 2a. (601 aa) |
| | foxf1 | Forkhead box protein F1. (380 aa) |
| | ism1 | Isthmin-1; May specifically influence certain angiogenesis process. (461 aa) |
| | efnb1 | Ephrin-B1; Belongs to the ephrin family. (341 aa) |
| | ptch1 | Protein patched homolog 1. (1475 aa) |
| | tnfa | Tumor necrosis factor a (TNF superfamily, member 2). (234 aa) |
| | snrkb | SNF-related kinase b. (741 aa) |
| | naca | Nascent polypeptide-associated complex subunit alpha; May promote appropriate targeting of ribosome-nascent polypeptide complexes. (215 aa) |
| | pes | Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa) |
| | g6pc3 | Glucose-6-phosphatase 3; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity); Belongs to the glucose-6-phosphatase family. (339 aa) |
| | eftud2 | Elongation factor Tu GTP-binding domain-containing 2. (973 aa) |
| | glra4a | Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa) |
| | klf6a | Kruppel-like factor 6a. (283 aa) |
| | adtrp1 | Androgen-dependent TFPI-regulating protein 1. (242 aa) |
| | tbx1 | T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa) |
| | iqsec1b | IQ motif and Sec7 domain ArfGEF 1b. (1252 aa) |
| | fbxw4 | F-box and WD repeat domain-containing 4. (392 aa) |
| | cdk10 | Cyclin-dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa) |
| | etv2 | ETS variant transcription factor 2. (366 aa) |
| | itga9 | Integrin, alpha 9; Belongs to the integrin alpha chain family. (1032 aa) |
| | fgf10a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa) |
| | rps19 | Ribosomal protein S19. (146 aa) |
| | ddx18 | RNA helicase. (653 aa) |
| | kdr | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa) |
| | notch1b | Notch receptor 1b. (2465 aa) |
| | ncor2 | Nuclear receptor corepressor 2. (2315 aa) |
| | hdac1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa) |
| | cdkn2aip | CDKN2A-interacting protein. (312 aa) |
| | smox | Spermine oxidase. (539 aa) |
| | snrnp70 | Small nuclear ribonucleoprotein 70 (U1). (495 aa) |
| | socs1a | Suppressor of cytokine-signaling 1a. (201 aa) |
| | sfrp5 | Secreted frizzled-related protein 5. (310 aa) |
| | utp11 | U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (250 aa) |
| | pttg1ipb | Pituitary tumor-transforming 1 interacting protein. (172 aa) |
| | snai2 | Snail homolog 2 (Drosophila). (257 aa) |
| | rps29 | Ribosomal protein S29. (56 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | selp | Selectin P. (868 aa) |
| | supt5h | Transcription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] (1084 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | fzd8a | Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa) |
| | col4a5 | Collagen, type IV, alpha 5 (Alport syndrome). (1679 aa) |
| | notch3 | Notch receptor 3. (2468 aa) |
| | tbl3 | Transducin beta-like 3. (897 aa) |
| | htt | Huntingtin. (3121 aa) |
| | myb | V-myb avian myeloblastosis viral oncogene homolog. (641 aa) |
| | prox1a | Prospero homeobox 1a. (739 aa) |
| | neurog1 | Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificati [...] (208 aa) |
| | sf3b1 | Splicing factor 3b, subunit 1. (1315 aa) |
| | hdac9b | Histone deacetylase 9-B; Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2- dependent transcription (By similarity). (612 aa) |
| | epas1b | Endothelial PAS domain protein 1b. (834 aa) |
| | stc1l | Stanniocalcin 1,-like. (249 aa) |
| | myef2 | Myelin expression factor 2. (553 aa) |
| | tal1 | T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa) |
| | sdc4 | Syndecan 4. (207 aa) |
| | camsap2b | Calmodulin-regulated spectrin-associated protein family, member 2b. (834 aa) |
| | ogg1 | 8-oxoguanine DNA glycosylase. (391 aa) |
| | f2r | Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa) |
| | ptger3 | Prostaglandin E receptor 3 (subtype EP3). (401 aa) |
| | kdm1a | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (833 aa) |
| | lrsam1 | Leucine-rich repeat and sterile alpha motif-containing 1. (721 aa) |
| | trim69 | Tripartite motif-containing 69. (548 aa) |
| | march2 | E3 ubiquitin-protein ligase MARCHF2; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (249 aa) |
| | jam3b | Junctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. (333 aa) |
| | stab1 | Stabilin 1. (2553 aa) |
| | IQSEC1 | SEC7 domain-containing protein. (953 aa) |
| | dld | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (717 aa) |
| | swap70b | Switching B cell complex subunit SWAP70b. (588 aa) |
| | vegfc | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa) |
| | ptger4a | Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (403 aa) |
| | dll4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (683 aa) |
| | hey1 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. (317 aa) |
| | vhl | Von Hippel-Lindau tumor suppressor. (175 aa) |
| | fezf2 | Fez family zinc finger protein 2; Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons. (438 aa) |
| | hmx3a | Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (297 aa) |
| | zdhhc15b | Palmitoyltransferase ZDHHC15B; Catalyzes palmitoylation of Cys residues on target proteins. (332 aa) |
| | gba | Glucosylceramidase. (518 aa) |
| | mak16 | Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa) |
| | birc5a | Baculoviral IAP repeat-containing 5a. (190 aa) |
| | kri1 | Protein KRI1 homolog; Belongs to the KRI1 family. (765 aa) |
| | ifngr1 | Interferon gamma receptor 1. (394 aa) |
| | dtx4a | Deltex 4, E3 ubiquitin ligase a. (704 aa) |
| | mettl22 | Methyltransferase-like 22. (357 aa) |
| | twistnb | DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity). (390 aa) |
| | ptgs1 | Prostaglandin-endoperoxide synthase 1. (597 aa) |
| | tnfrsf1b | Tumor necrosis factor receptor superfamily, member 1B. (425 aa) |
| | hoxc9a | Homeobox protein Hox-C9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (270 aa) |
| | wnt9a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa) |
| | emilin1a | Elastin microfibril interfacer 1a. (1014 aa) |
| | ccbe1 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. (401 aa) |
| | prdm16 | Si:ch211-263k4.2. (927 aa) |
| | etv5a | ETS variant transcription factor 5a. (524 aa) |
| | junba | JunB proto-oncogene, AP-1 transcription factor subunit a. (325 aa) |
| | mecp2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa) |
| | gnl3 | Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa) |
| | gle1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa) |
| | ecscr | Endothelial cell surface-expressed chemotaxis and apoptosis regulator. (249 aa) |
| | max | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity). (160 aa) |
| | runx1 | Runt-related transcription factor. (451 aa) |
| | ptger2a | Prostaglandin E2 receptor subtype EP2-like; Belongs to the G-protein coupled receptor 1 family. (368 aa) |
| | fbxw7 | F-box and WD repeat domain-containing 7. (544 aa) |
| | myo6a | Myosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1288 aa) |
| | adora2b | Adenosine A2b receptor. (351 aa) |
| | sox18 | SRY-box transcription factor 18. (431 aa) |
| | chd7 | Chromodomain helicase DNA-binding protein 7. (3140 aa) |
| | rap1b | Ras-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa) |
| | hlx1 | H2.0-like homeo box 1 (Drosophila). (356 aa) |
| | stab2 | Stabilin 2. (2543 aa) |
| | tmem88a | Transmembrane protein 88 a. (219 aa) |
| | ppp1r12a | Protein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa) |
| | plcg1 | Phosphoinositide phospholipase C. (1020 aa) |
| | jag1a | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa) |
| | urb2 | URB2 ribosome biogenesis homolog. (1495 aa) |
| | birc5b | Baculoviral IAP repeat-containing 5b. (144 aa) |
| | bloc1s2 | Biogenesis of lysosomal organelles complex-1, subunit 2. (177 aa) |
| | tgfb1b | Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa) |
| | wnt16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa) |
| | ifng1 | Interferon gamma 1. (179 aa) |
| | epb41l5 | Erythrocyte membrane protein band 4.1-like 5. (461 aa) |
| | wdr43 | WD repeat domain 43. (650 aa) |
| | tnnt2a | Troponin T type 2a (cardiac). (282 aa) |
| | nrp2a | Neuropilin; Belongs to the neuropilin family. (927 aa) |
| | clocka | Clock circadian regulator a. (892 aa) |
| | nova2 | NOVA alternative-splicing regulator 2. (517 aa) |
| | ap2a1 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa) |
| | znf644b | Zinc finger protein 644b. (1267 aa) |
| | cpsf1 | Cleavage and polyadenylation-specific factor 1. (1451 aa) |
| | lrp2a | Low density lipoprotein receptor-related protein 2a. (4673 aa) |
| | akt1 | Non-specific serine/threonine protein kinase. (247 aa) |
| | lamb1a | Laminin, beta 1a. (1785 aa) |
| | znf644a | Zinc finger protein 644a. (1169 aa) |
| | junbb | JunB proto-oncogene, AP-1 transcription factor subunit b. (310 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | nop10 | H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (64 aa) |
| | nedd4a | E3 ubiquitin-protein ligase. (787 aa) |
| | sufu | Suppressor of fused homolog. (485 aa) |
| | flt4 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa) |
| | foxi1 | Forkhead box I1. (377 aa) |
| | gipc1 | Regulator of G-protein signaling 19-interacting protein 1. (335 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | ddx46 | Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1018 aa) |
| | nos1 | Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa) |
| | rspo1 | R-spondin-1; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Belongs to the R-spondin family. (261 aa) |
| | arnt2 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor. (737 aa) |
| | cxcl8a | Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (98 aa) |
| | metap2b | Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (476 aa) |
| | tfec | Transcription factor EC. (396 aa) |
| | nop14 | NOP14 nucleolar protein homolog (yeast). (767 aa) |
| | sf3a3 | Splicing factor 3a, subunit 3. (501 aa) |
| | etfa | Electron-transfer-flavoprotein, alpha polypeptide. (333 aa) |
| | hal | Histidine ammonia-lyase; Belongs to the PAL/histidase family. (654 aa) |
| | arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1664 aa) |
| | svep1 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1. (3615 aa) |
| | iqcg | Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (camk4) activity; contributes to the regulation of camk4 signaling cascades. Plays a role in the regulation of definitive hematopoiesis via its effects on camk4. Belo [...] (346 aa) |
| | gfi1b | Growth factor-independent 1B transcription repressor. (334 aa) |
| | aggf1 | Angiogenic factor with G patch and FHA domains 1. (775 aa) |
| | stat4 | Signal transducer and activator of transcription. (741 aa) |
| | tcf7l1b | Transcription factor 7-like 1-B; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Also required for hindbrain morphogenesis. Belongs to the TCF/LEF family. (585 aa) |
| | npas4l | Neuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa) |
