STRINGSTRING
gli2a gli2a isl1 isl1 smo smo pink1 pink1 tbx6 tbx6 igf1ra igf1ra smn1 smn1 snap25a snap25a isl2a isl2a racgap1 racgap1 noto noto scn8aa scn8aa spast spast pnx pnx nkx6.1 nkx6.1 myf6 myf6 asah1b asah1b chodl chodl plxna3 plxna3 igf1rb igf1rb fus fus fbxo5 fbxo5 rapsn rapsn tbc1d23 tbc1d23 disp1 disp1 pcdh18b pcdh18b inab inab pgk1 pgk1 epas1b epas1b gars1 gars1 sdc4 sdc4 plod3 plod3 col15a1b col15a1b psenen psenen kif15 kif15 wnt11 wnt11 ccndx ccndx col19a1 col19a1 mnx2b mnx2b atl1 atl1 insm1a insm1a mecp2 mecp2 ncaldb ncaldb stim1a stim1a appb appb loxa loxa chp1 chp1 prdm14 prdm14 epb41l3a epb41l3a zfyve27 zfyve27 grna grna lamc3 lamc3 fignl1 fignl1 ppp1r12a ppp1r12a nrxn2a nrxn2a pld1a pld1a las1l las1l pitpnaa pitpnaa mfn2 mfn2 met met disc1 disc1 notum2 notum2 gli1 gli1 plxnb1b plxnb1b mib1 mib1 agrn agrn syn2b syn2b ntn1a ntn1a hnrnpr hnrnpr slc1a2b slc1a2b rest rest dcc dcc neo1a neo1a sema5a sema5a notch1a notch1a plxnb1a plxnb1a thsd7aa thsd7aa musk musk nkx6.2 nkx6.2 nrp1a nrp1a dctn1a dctn1a nckap1 nckap1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gli2aGLI family zinc finger 2a. (1439 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
pink1PTEN-induced kinase 1. (574 aa)
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
igf1raTyrosine-protein kinase receptor. (1405 aa)
smn1Survival motor neuron protein 1; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites. (281 aa)
snap25aSynaptosomal-associated protein 25-A; May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion; Belongs to the SNAP-25 family. (204 aa)
isl2aInsulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. (359 aa)
racgap1Rac GTPase-activating protein 1. (654 aa)
notoNotochord homeobox. (241 aa)
scn8aaSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1949 aa)
spastSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (570 aa)
pnxHomeobox protein pnx; Transcriptional repressor. Activity as a repressor is enhanced by binding to the corepressor tle3a. (182 aa)
nkx6.1NK6 homeobox 1. (312 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
asah1bN-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. (395 aa)
chodlChondrolectin; Plays a role in the development of the nervous system such as in neurite outgrowth and elongation. Involved in motor axon growth and guidance. Required for correct interactions of motor axons with the horizontal myoseptum. (296 aa)
plxna3Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. (1892 aa)
igf1rbTyrosine-protein kinase receptor. (1380 aa)
fusFUS RNA-binding protein. (541 aa)
fbxo5F-box only protein 5; During embryonic development, regulates the integrity of the genome and therefore the cell cycle progression by preventing rereplication through an APC-Cdh1-dependent mechanism. (384 aa)
rapsnReceptor-associated protein of the synapse, 43kD. (412 aa)
tbc1d23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development. May act as a general inhibitor of innate immunity signaling (By similarity). (680 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
pcdh18bProtocadherin 18b. (1150 aa)
inabInternexin neuronal intermediate filament protein, alpha b; Belongs to the intermediate filament family. (469 aa)
pgk1Phosphoglycerate kinase. (417 aa)
epas1bEndothelial PAS domain protein 1b. (834 aa)
gars1Glycyl-tRNA synthetase. (690 aa)
sdc4Syndecan 4. (207 aa)
plod3Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3. (730 aa)
col15a1bCollagen, type XV, alpha 1b. (1245 aa)
psenenGamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa)
kif15Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1378 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ccndxCyclin Dx; Belongs to the cyclin family. (324 aa)
col19a1Collagen, type XIX, alpha 1. (303 aa)
mnx2bMotor neuron and pancreas homeobox 2b. (328 aa)
atl1Atlastin GTPase 1. (554 aa)
insm1aInsulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
ncaldbNeurocalcin-delta B; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). (192 aa)
stim1aStromal interaction molecule 1a. (676 aa)
appbAmyloid beta (A4) precursor protein b. (694 aa)
loxaLysyl oxidase a. (408 aa)
chp1Calcineurin-like EF-hand protein 1. (194 aa)
prdm14PR domain-containing 14. (568 aa)
epb41l3aErythrocyte membrane protein band 4.1-like 3a. (826 aa)
zfyve27Zinc finger, FYVE domain-containing 27. (409 aa)
grnaGranulin a. (1049 aa)
lamc3Laminin, gamma 3. (1643 aa)
fignl1Fidgetin-like 1; Belongs to the AAA ATPase family. (661 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
nrxn2aNeurexin 2a. (648 aa)
pld1aPhospholipase. (1022 aa)
las1lLAS1-like ribosome biogenesis factor. (580 aa)
pitpnaaPhosphatidylinositol transfer protein, alpha a. (271 aa)
mfn2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
disc1DISC1 scaffold protein. (994 aa)
notum2Carboxylesterase notum2; Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling. (495 aa)
gli1GLI family zinc finger 1. (1404 aa)
plxnb1bPlexin b1b. (2220 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
agrnAgrin. (1926 aa)
syn2bSynapsin IIb. (695 aa)
ntn1aNetrin-1a. (603 aa)
hnrnprHeterogeneous nuclear ribonucleoprotein R. (637 aa)
slc1a2bAmino acid transporter. (564 aa)
restRE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa)
dccDCC netrin 1 receptor. (1200 aa)
neo1aNeogenin 1a. (1428 aa)
sema5aSemaphorin-5A. (1048 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
plxnb1aPlexin b1a. (1945 aa)
thsd7aaThrombospondin type-1 domain-containing protein 7A; Required for normal sprouting angiogenesis and normal embryonic development of intersegmental vessels (ISV). Required for normal function of the glomerular filtration barrier. Required for normal axon outgrowth on embryonic motor neurons at the level of the horizontal myoseptum. Required for normal expression of notch1b, suggesting that its functions in angiogenesis and neuron outgrowth are due to decreased expression of notch1b. Plays a role in actin cytoskeleton rearrangement (By similarity). (1684 aa)
muskMuscle, skeletal, receptor tyrosine kinase. (351 aa)
nkx6.2NK6 homeobox 2. (278 aa)
nrp1aNeuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa)
dctn1aDynactin 1a. (1257 aa)
nckap1Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). (1134 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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