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| | pcgf1 | Polycomb group RING finger protein 1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. (295 aa) |
| | ewsr1b | Ewing sarcoma breakpoint region 1b. (579 aa) |
| | traf3ip1 | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). (629 aa) |
| | flt1 | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa) |
| | esco2 | N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development. (609 aa) |
| | nsd2 | Nuclear receptor-binding SET domain protein 2. (1461 aa) |
| | col1a1b | Collagen, type I, alpha 1b. (1449 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | col1a1a | Collagen, type I, alpha 1a. (1447 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | prkci | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa) |
| | sec63 | SEC63 homolog, protein translocation regulator. (751 aa) |
| | kif11 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1062 aa) |
| | degs1 | Delta(4)-desaturase, sphingolipid 1. (323 aa) |
| | smarcd1 | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 1. (510 aa) |
| | jag2b | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1254 aa) |
| | zc4h2 | Zinc finger C4H2 domain-containing protein; Plays a role in GABAergic and V2 interneurons differentiation. Involved in motoneuron development and in neuromuscular junction formation. (224 aa) |
| | plod2 | Procollagen lysine 2-oxoglutarate 5-dioxygenase 2b isoform. (754 aa) |
| | dla | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] (772 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | rras | Related RAS viral (R-ras) oncogene homolog. (196 aa) |
| | pink1 | PTEN-induced kinase 1. (574 aa) |
| | prdm12b | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (366 aa) |
| | nedd1 | NEDD1 gamma-tubulin ring complex targeting factor. (677 aa) |
| | neflb | Neurofilament, light polypeptide b; Belongs to the intermediate filament family. (579 aa) |
| | gata3 | Transcription factor GATA-3. (438 aa) |
| | chm | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa) |
| | dvl2 | Dishevelled segment polarity protein 2. (747 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | ewsr1a | EWS RNA-binding protein 1a. (626 aa) |
| | pes | Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa) |
| | eftud2 | Elongation factor Tu GTP-binding domain-containing 2. (973 aa) |
| | spast | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (570 aa) |
| | glra4a | Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa) |
| | nek1 | NIMA-related kinase 1. (1200 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | rfx4 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family. (735 aa) |
| | asah1b | N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. (395 aa) |
| | tdgf1 | Teratocarcinoma-derived growth factor 1. (190 aa) |
| | plxna3 | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. (1892 aa) |
| | dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9. (252 aa) |
| | adarb1a | Adenosine deaminase RNA-specific B1a. (720 aa) |
| | capn1a | Calpain 1, (mu/I) large subunit a; Belongs to the peptidase C2 family. (704 aa) |
| | gmds | GDP-mannose 4,6 dehydratase. (370 aa) |
| | kif1b | Kinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1770 aa) |
| | slc25a46 | Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission. (405 aa) |
| | lingo1b | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. (622 aa) |
| | ache | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa) |
| | scrt2 | Scratch family zinc finger 2. (312 aa) |
| | pmm2 | Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (250 aa) |
| | cln3 | Battenin. (446 aa) |
| | gdf3 | Protein DVR-1; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. (355 aa) |
| | sulf1 | Sulfatase FP1c. (1099 aa) |
| | fer1l6 | Fer-1-like family member 6. (1790 aa) |
| | terfa | Telomeric repeat-binding factor a. (574 aa) |
| | utp11 | U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (250 aa) |
| | gli3 | GLI family zinc finger 3. (1553 aa) |
| | prickle1a | Prickle homolog 1a. (793 aa) |
| | olig2 | Oligodendrocyte lineage transcription factor 2. (273 aa) |
| | dharma | Dharma. (192 aa) |
| | coasy | CoA synthase. (554 aa) |
| | ppm1e | Protein phosphatase, Mg2+/Mn2+-dependent, 1E. (633 aa) |
| | wdr78 | WD repeat domain 78. (778 aa) |
| | abcc4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4. (1327 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | rdh10a | Retinol dehydrogenase 10-A; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa) |
| | fzd8a | Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa) |
| | ist1 | IST1 factor-associated with ESCRT-III. (354 aa) |
| | gdf6a | Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa) |
| | aldh1a2 | Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | sox3 | Transcription factor Sox-3; Transcriptional activator. (300 aa) |
| | lmx1bb | LIM homeobox transcription factor 1, beta 1. (375 aa) |
| | pogza | Pogo transposable element-derived with ZNF domain a. (1277 aa) |
| | leo1 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. (696 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | cybb | Cytochrome b-245, beta polypeptide (chronic granulomatous disease). (565 aa) |
| | cdk5 | Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | chaf1b | Chromatin assembly factor 1, subunit B. (613 aa) |
| | gabra2a | Gamma-aminobutyric acid type A receptor alpha2 subunit a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa) |
| | Nfascb | Uncharacterized protein. (380 aa) |
| | plk1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | ctnnb2 | Catenin, beta 2. (778 aa) |
| | ihhb | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa) |
| | evx2 | Even-skipped homeobox 2. (418 aa) |
| | sdc4 | Syndecan 4. (207 aa) |
| | gba2 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (851 aa) |
| | kifbp | KIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. (631 aa) |
| | shank3a | SH3 and multiple ankyrin repeat domains 3a. (1509 aa) |
| | peli1b | Pellino E3 ubiquitin protein ligase 1b. (425 aa) |
| | syngap1b | Synaptic Ras GTPase-activating protein 1b. (1507 aa) |
| | prpf4 | PRP4 pre-mRNA-processing factor 4 homolog (yeast). (507 aa) |
| | msi1 | Musashi RNA-binding protein 1. (297 aa) |
| | ptk7a | Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa) |
| | actr10 | Actin-related protein 10; Belongs to the actin family. (415 aa) |
| | psenen | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa) |
| | swap70b | Switching B cell complex subunit SWAP70b. (588 aa) |
| | sptan1 | Spectrin alpha, non-erythrocytic 1. (2480 aa) |
| | gria2a | Glutamate receptor, ionotropic, AMPA 2a. (875 aa) |
| | skib | V-ski avian sarcoma viral oncogene homolog b. (695 aa) |
| | vsx1 | Visual system homeobox 1; May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells. May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems; Belongs to the paired homeobox family. (340 aa) |
| | stat3 | Signal transducer and activator of transcription. (806 aa) |
| | abhd12 | Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase act [...] (382 aa) |
| | gbx1 | Gastrulation brain homeobox 1. (316 aa) |
| | glra2 | Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa) |
| | ids | Iduronate 2-sulfatase. (561 aa) |
| | cdx4 | Caudal type homeo box transcription factor 4. (270 aa) |
| | gba | Glucosylceramidase. (518 aa) |
| | ocrl | OCRL inositol polyphosphate-5-phosphatase. (953 aa) |
| | mak16 | Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa) |
| | ascc1 | Activating signal cointegrator 1 complex subunit 1. (249 aa) |
| | sox10 | HMG-box transcription factor Sox10. (485 aa) |
| | cluap1 | Clusterin-associated protein 1 homolog; Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Belongs to the CLUAP1 family. (427 aa) |
| | abcd1 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination. (766 aa) |
| | twist2 | Twist2. (163 aa) |
| | dtx4a | Deltex 4, E3 ubiquitin ligase a. (704 aa) |
| | adgra2 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] (1367 aa) |
| | twistnb | DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity). (390 aa) |
| | mtor | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa) |
| | ptena | Phosphatase and tensin homolog A; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (467 aa) |
| | auts2a | Activator of transcription and developmental regulator AUTS2 a. (1278 aa) |
| | rab11fip4a | Rab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa) |
| | slc33a1 | Solute carrier family 33 member 1. (541 aa) |
| | pard3ab | Par-3 family cell polarity regulator alpha, b. (1332 aa) |
| | fshb | Follicle-stimulating hormone beta subunit. (130 aa) |
| | gnl3 | Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa) |
| | clu | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa) |
| | gle1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa) |
| | loxa | Lysyl oxidase a. (408 aa) |
| | fbxw7 | F-box and WD repeat domain-containing 7. (544 aa) |
| | grna | Granulin a. (1049 aa) |
| | ccnk | Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). (526 aa) |
| | htr1ab | 5-hydroxytryptamine (serotonin) receptor 1A b. (413 aa) |
| | med23 | Mediator of RNA polymerase II transcription subunit 23; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1387 aa) |
| | ppp1r12a | Protein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa) |
| | col1a2 | Collagen, type I, alpha 2. (1352 aa) |
| | dnaaf3 | Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family. (469 aa) |
| | il7r | Interleukin 7 receptor. (372 aa) |
| | vegfab | Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (251 aa) |
| | prpf8 | Pre-mRNA-processing factor 8. (2342 aa) |
| | l1camb | Neural cell adhesion molecule L1.1; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1332 aa) |
| | sox11b | Transcription factor SOX. (368 aa) |
| | fut8a | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (581 aa) |
| | otpa | Orthopedia homeobox a. (332 aa) |
| | pitpnaa | Phosphatidylinositol transfer protein, alpha a. (271 aa) |
| | col17a1a | Collagen, type XVII, alpha 1a. (1408 aa) |
| | cenph | Centromere protein H. (233 aa) |
| | lrrk2 | Leucine-rich repeat kinase 2. (2532 aa) |
| | als2b | Alsin Rho guanine nucleotide exchange factor ALS2 b. (1681 aa) |
| | tert | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa) |
| | pla2g6 | Phospholipase A2, group VI (cytosolic, calcium-independent). (824 aa) |
| | cntnap1 | Contactin-associated protein 1. (1309 aa) |
| | cdc73 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa) |
| | slc6a6b | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (574 aa) |
| | psd2 | Pleckstrin and Sec7 domain-containing 2. (837 aa) |
| | dnaaf4 | Dynein axonemal assembly factor 4. (420 aa) |
| | ptpn12 | Protein tyrosine phosphatase non-receptor type 12. (170 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | agrn | Agrin. (1926 aa) |
| | cfap53 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis; Belongs to the CFAP53 family. (519 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | ap1g2 | AP-1 complex subunit gamma. (794 aa) |
| | gabra1 | Gamma-aminobutyric acid (GABA) A receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (459 aa) |
| | psen1 | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa) |
| | rtn4b | Reticulon. (876 aa) |
| | trip4 | Thyroid hormone receptor interactor 4. (564 aa) |
| | cdh1 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa) |
| | glrx2 | Glutaredoxin 2. (170 aa) |
| | hmgcs1 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa) |
| | exosc3 | Exosome component 3. (247 aa) |
| | drd4a | Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (380 aa) |
| | ptmab | Prothymosin alpha-B. (106 aa) |
| | notch1a | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa) |
| | dync1h1 | Dynein, cytoplasmic 1, heavy chain 1. (1765 aa) |
| | thsd7aa | Thrombospondin type-1 domain-containing protein 7A; Required for normal sprouting angiogenesis and normal embryonic development of intersegmental vessels (ISV). Required for normal function of the glomerular filtration barrier. Required for normal axon outgrowth on embryonic motor neurons at the level of the horizontal myoseptum. Required for normal expression of notch1b, suggesting that its functions in angiogenesis and neuron outgrowth are due to decreased expression of notch1b. Plays a role in actin cytoskeleton rearrangement (By similarity). (1684 aa) |
| | ap1g1 | AP-1 complex subunit gamma. (819 aa) |
| | adgrg1 | Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (648 aa) |
| | etfa | Electron-transfer-flavoprotein, alpha polypeptide. (333 aa) |
| | evx1 | Even-skipped homeobox 1. (377 aa) |
| | ndr2 | Nodal-related 2. (505 aa) |
| | nptx2a | Neuronal pentraxin 2a. (433 aa) |
| | tmem33 | Transmembrane protein 33. (252 aa) |
| | csf1ra | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa) |
| | prmt8b | Protein arginine N-methyltransferase 8-B; S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily. (420 aa) |
| | bmp1a | Metalloendopeptidase. (986 aa) |
| | rraga | Ras-related GTP-binding A. (316 aa) |
| | gdpd5a | Glycerophosphodiester phosphodiesterase domain-containing 5a. (621 aa) |
| | nkx2.2a | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa) |
| | tfeb | Transcription factor EB. (493 aa) |
