STRINGSTRING
rnf2 rnf2 sox9a sox9a gpc4 gpc4 ctsk ctsk rer1 rer1 mbtps1 mbtps1 dlx1a dlx1a ube2ib ube2ib smo smo wls wls gata3 gata3 fam20b fam20b slc35b2 slc35b2 chrna1 chrna1 ewsr1a ewsr1a irx7 irx7 frzb frzb coro1ca coro1ca sec61a1 sec61a1 sec24d sec24d nup107 nup107 chst11 chst11 tmem165 tmem165 enpp2 enpp2 matn1 matn1 hdac1 hdac1 kmt2d kmt2d disp1 disp1 cnbpa cnbpa pax9 pax9 cog4 cog4 sec13 sec13 uxs1 uxs1 ext2 ext2 tapt1b tapt1b xylt1 xylt1 nolc1 nolc1 ccn6 ccn6 sox10 sox10 rerea rerea dlx2a dlx2a kif5ba kif5ba sec31a sec31a wnt9a wnt9a gnptab gnptab fzd7a fzd7a marcksa marcksa loxl3b loxl3b znf385c znf385c shox shox chd7 chd7 rbms3 rbms3 cacna1c cacna1c eif2ak3 eif2ak3 scfd1 scfd1 extl3 extl3 b3gat3 b3gat3 col11a2 col11a2 ostn ostn creb3l2 creb3l2 sufu sufu wnt5b wnt5b sec23a sec23a lpar1 lpar1 fis1 fis1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rnf2E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa)
sox9aHMG box transcription factor Sox9a. (462 aa)
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
ctskCathepsin K; Belongs to the peptidase C1 family. (333 aa)
rer1Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (196 aa)
mbtps1Membrane-bound transcription factor peptidase, site 1. (1074 aa)
dlx1aHomeobox protein Dlx1a. (252 aa)
ube2ibSUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
wlsWnt ligand secretion mediator. (542 aa)
gata3Transcription factor GATA-3. (438 aa)
fam20bGlycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases (By similarity). Belongs to the FAM20 family. (409 aa)
slc35b2Solute carrier family 35, member B2. (435 aa)
chrna1Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa)
ewsr1aEWS RNA-binding protein 1a. (626 aa)
irx7Iroquois homeodomain transcription factor Ziro7. (314 aa)
frzbFrizzled-related protein. (315 aa)
coro1caCoronin-1C-A; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (Probable). Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. [...] (474 aa)
sec61a1Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. (476 aa)
sec24dSEC24 homolog D, COPII coat complex component. (1030 aa)
nup107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (919 aa)
chst11Carbohydrate sulfotransferase 11; Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. (352 aa)
tmem165GDT1 family protein. (305 aa)
enpp2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (850 aa)
matn1Matrilin 1. (489 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
kmt2dLysine (K)-specific methyltransferase 2D. (3325 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
cnbpaCCHC-type zinc finger, nucleic acid-binding protein a. (163 aa)
pax9Paired box 9. (343 aa)
cog4Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in the vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity); Belongs to the COG4 family. (781 aa)
sec13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
uxs1UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Essential during embryogenesis for craniofacial development. Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (418 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
tapt1bTransmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. Involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells. May act as a downstream effector of hoxc8 during development (By similarity). (567 aa)
xylt1Xylosyltransferase I. (919 aa)
nolc1Nucleolar and coiled-body phosphoprotein 1. (1001 aa)
ccn6WNT1 inducible signaling pathway protein 3. (338 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
rereaArginine-glutamic acid dipeptide (RE) repeats a. (1531 aa)
dlx2aHomeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa)
kif5baKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (968 aa)
sec31aProtein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1250 aa)
wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
gnptabN-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. (1219 aa)
fzd7aFrizzled class receptor 7a; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
marcksaMyristoylated alanine-rich protein kinase C substrate a. (236 aa)
loxl3bLysyl oxidase homolog 3B; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (By similarity). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (By similarity). Can mediate oxidation of lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues (By similarity). Required for maturation of neural crest derived car [...] (807 aa)
znf385cZinc finger protein 385C. (459 aa)
shoxShort stature homeobox. (285 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
rbms3RNA-binding motif, single stranded-interacting protein. (409 aa)
cacna1cVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2196 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa)
scfd1Sec1 family domain-containing 1; Belongs to the STXBP/unc-18/SEC1 family. (632 aa)
extl3Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (917 aa)
b3gat3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (330 aa)
col11a2Collagen, type XI, alpha 2. (1803 aa)
ostnOsteocrin. (134 aa)
creb3l2Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...] (519 aa)
sufuSuppressor of fused homolog. (485 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
sec23aProtein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (280 aa)
fis1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (153 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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