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gli2a gli2a isl1 isl1 tbx6 tbx6 chodl chodl plxna3 plxna3 plod3 plod3 insm1a insm1a disc1 disc1 notch1a notch1a thsd7aa thsd7aa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
gli2aGLI family zinc finger 2a. (1439 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
chodlChondrolectin; Plays a role in the development of the nervous system such as in neurite outgrowth and elongation. Involved in motor axon growth and guidance. Required for correct interactions of motor axons with the horizontal myoseptum. (296 aa)
plxna3Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. (1892 aa)
plod3Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3. (730 aa)
insm1aInsulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa)
disc1DISC1 scaffold protein. (994 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
thsd7aaThrombospondin type-1 domain-containing protein 7A; Required for normal sprouting angiogenesis and normal embryonic development of intersegmental vessels (ISV). Required for normal function of the glomerular filtration barrier. Required for normal axon outgrowth on embryonic motor neurons at the level of the horizontal myoseptum. Required for normal expression of notch1b, suggesting that its functions in angiogenesis and neuron outgrowth are due to decreased expression of notch1b. Plays a role in actin cytoskeleton rearrangement (By similarity). (1684 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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