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| | dpm2 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (83 aa) |
| | thraa | Thyroid hormone receptor alpha-A; High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (427 aa) |
| | rnf2 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa) |
| | nfe2 | Nuclear factor, erythroid 2. (466 aa) |
| | dmd | Dystrophin. (594 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | rab5b | RAB5B, member RAS oncogene family. (214 aa) |
| | noc3l | Nucleolar complex protein 3 homolog; Belongs to the CBF/MAK21 family. (800 aa) |
| | nkx2.7 | NK2 transcription factor-related 7. (269 aa) |
| | prdm1a | PR domain-containing 1a, with ZNF domain. (776 aa) |
| | myl1 | Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (190 aa) |
| | lama4 | Laminin, alpha 4. (1871 aa) |
| | gpc4 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | dnajb6a | DnaJ heat shock protein family (Hsp40) member B6a. (316 aa) |
| | myod1 | Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa) |
| | cdkn1ca | Cyclin-dependent kinase inhibitor 1C (P57, Kip2). (212 aa) |
| | spns1 | Protein spinster homolog 1; Sphingolipid transporter. (504 aa) |
| | erbb2 | Receptor protein-tyrosine kinase. (1275 aa) |
| | myog | Myogenin. (256 aa) |
| | dnajb6b | DnaJ heat shock protein family (Hsp40) member B6b. (237 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | ddx39ab | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Ab. (427 aa) |
| | ptbp1a | Polypyrimidine tract-binding protein 1a. (574 aa) |
| | vcp | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa) |
| | klhl41b | Kelch-like protein 41b; Involved in skeletal muscle development and maintenance. (605 aa) |
| | heg1 | Protein HEG; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. (977 aa) |
| | hsp90b1 | Heat shock protein 90, beta (Grp94), member 1. (793 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | casr | Calcium-sensing receptor. (946 aa) |
| | barx1 | Homeobox protein BarH-like 1; Transcription factor, is involved in craniofacial development, and in stomach organogenesis; Belongs to the BAR homeobox family. (248 aa) |
| | tbx6 | T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa) |
| | naa15a | N(alpha)-acetyltransferase 15, NatA auxiliary subunit a. (867 aa) |
| | wls | Wnt ligand secretion mediator. (542 aa) |
| | nkx2.5 | NK2 homeobox 5. (314 aa) |
| | rbfox1l | RNA binding protein fox-1 homolog 1-like; RNA-binding protein that regulates alternative splicing events by binding to 5'-GCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. (382 aa) |
| | hdac8 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (378 aa) |
| | shox2 | Short stature homeobox 2. (299 aa) |
| | pax3b | Paired box 3b. (469 aa) |
| | dag1 | Dystroglycan 1. (866 aa) |
| | chrna1 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa) |
| | hsp90aa1.1 | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa) |
| | ccm2 | Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). (455 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | unc45b | Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa) |
| | smad7 | Mothers against decapentaplegic homolog. (372 aa) |
| | lamc1 | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa) |
| | hspb11 | Heat shock protein beta-11; Belongs to the small heat shock protein (HSP20) family. (205 aa) |
| | smyd1a | SET and MYND domain-containing 1a. (465 aa) |
| | tcap | Titin-cap (telethonin). (179 aa) |
| | six1b | Homeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa) |
| | spi1b | SI:bY184L24.2.1 (Transcription factor spi1). (296 aa) |
| | med29 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (179 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | dpf3 | Zinc finger protein DPF3; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). Plays an essential role in heart and skeletal [...] (391 aa) |
| | tbx5a | T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa) |
| | rab5c | RAB5C, member RAS oncogene family. (221 aa) |
| | tnni2a.4 | Troponin I type 2a (skeletal, fast), tandem duplicate 4. (176 aa) |
| | pax3a | Transcription factor PAX3. (509 aa) |
| | chchd4a | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] (146 aa) |
| | tbx1 | T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa) |
| | myh11a | Myosin, heavy polypeptide 11, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa) |
| | kif7 | Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa) |
| | glra1 | Glycine receptor subunit alphaZ1; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity); Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily. (459 aa) |
| | pard6gb | Par-6 partitioning defective 6-like protein gamma. (434 aa) |
| | cars1 | Cysteinyl-tRNA synthetase. (824 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | tcf21 | Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa) |
| | cxcl12a | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | scube2 | Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa) |
| | pls3 | Plastin 3 (T isoform). (627 aa) |
| | fer1l6 | Fer-1-like family member 6. (1790 aa) |
| | bag3 | BCL2-associated athanogene 3. (480 aa) |
| | fbxo32 | F-box protein 32. (356 aa) |
| | hspb1 | Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (199 aa) |
| | cryaba | Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (168 aa) |
| | st8sia3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (374 aa) |
| | cct5 | Chaperonin-containing TCP1, subunit 5 (epsilon). (541 aa) |
| | b3galnt2 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O- glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (dag1) glycosylation; Belongs to the glycosyltransferase 31 family. (491 aa) |
| | rbfox2 | RNA-binding fox-1 homolog 2. (241 aa) |
| | ptpmt1 | Protein tyrosine phosphatase, mitochondrial 1. (183 aa) |
| | aldh1a2 | Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) |
| | smyd2a | N-lysine methyltransferase SMYD2-A; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. (435 aa) |
| | ret | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1106 aa) |
| | ldb3a | Cypher/ZASP splice variant 1 gamma. (596 aa) |
| | ext2 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa) |
| | cavin4b | Caveolae-associated protein 4b. (318 aa) |
| | ilk | Integrin-linked kinase. (452 aa) |
| | dpm1 | Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (250 aa) |
| | ctsd | Ctsd protein; Belongs to the peptidase A1 family. (398 aa) |
| | bves | Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa) |
| | popdc3 | Popeye domain-containing 3. (294 aa) |
| | desma | Desmin a; Belongs to the intermediate filament family. (488 aa) |
| | ihha | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa) |
| | dysf | Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive). (2097 aa) |
| | atcaya | ATCAY kinesin light chain-interacting caytaxin a. (367 aa) |
| | mtmr12 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location. By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis. In skeletal muscle cells, does not regulate mtm1 subcellular localization. (736 aa) |
| | rnf121 | Ring finger protein 121. (331 aa) |
| | pgm5 | Phosphoglucomutase 5. (567 aa) |
| | pxnb | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa) |
| | ripor2 | Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis an [...] (1083 aa) |
| | col15a1b | Collagen, type XV, alpha 1b. (1245 aa) |
| | slc8a1a | Solute carrier family 8 member 1a; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (969 aa) |
| | pleca | Plectin a. (4577 aa) |
| | golga2 | Cis-Golgi matrix protein GM130. (1028 aa) |
| | nup210 | Nucleoporin 210. (1873 aa) |
| | robo1 | Roundabout, axon guidance receptor, homolog 1 (Drosophila). (1687 aa) |
| | hmgcra | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa) |
| | ppargc1a | Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (859 aa) |
| | ambra1a | Activating molecule in beclin-1-regulated autophagy. (1315 aa) |
| | mef2ca | Myocyte enhancer factor 2ca. (465 aa) |
| | rabggtb | Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (331 aa) |
| | klhl41a | Kelch-like protein 41a; Involved in skeletal muscle development and differentiation. (599 aa) |
| | mstnb | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa) |
| | popdc2 | Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding. (370 aa) |
| | thbs4b | Thrombospondin-4-B; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response (By similarity); Belongs to the thrombospondin family. (949 aa) |
| | foxf2b | Forkhead box F2b. (429 aa) |
| | chac1 | Glutathione-specific gamma-glutamylcyclotransferase 1; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Not [...] (196 aa) |
| | tnnt3a | Troponin T type 3a (skeletal, fast). (230 aa) |
| | pdgfra | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa) |
| | scn4ab | Sodium channel protein type 4 subunit alpha B; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles. (1835 aa) |
| | pbx4 | Pre-B-cell leukemia transcription factor 4. (343 aa) |
| | edn1 | Endothelin 1. (188 aa) |
| | meox1 | Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa) |
| | lrrc39 | Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress (By similarity). May regulate expression of other M-band proteins via an SRF-dependent pathway (By similarity). Important for normal contractile function in heart. (343 aa) |
| | fhl1a | Four and a half LIM domains 1a. (297 aa) |
| | plekho1b | Pleckstrin homology domain-containing, family O member 1b. (402 aa) |
| | itga6a | Integrin, alpha 6a; Belongs to the integrin alpha chain family. (1092 aa) |
| | ttn.2 | Titin, tandem duplicate 2. (26265 aa) |
| | f11r.1 | F11 receptor, tandem duplicate 1. (292 aa) |
| | myot | Myotilin. (561 aa) |
| | cyp26b1 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa) |
| | b4gat1 | Beta-1,4-glucuronyltransferase 1; Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose- beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O- mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G- like domain-containing extracellular proteins with high affinity. Required for [...] (431 aa) |
| | col6a1 | Collagen, type VI, alpha 1. (1007 aa) |
| | ddx27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; Belongs to the DEAD box helicase family. (776 aa) |
| | foxc1a | Forkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa) |
| | wnt9a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa) |
| | f10 | Coagulation factor X. (504 aa) |
| | gfra3 | GDNF family receptor alpha 3. (458 aa) |
| | pomk | Protein O-mannose kinase; Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)- beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4- (phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (dag1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only [...] (347 aa) |
| | appb | Amyloid beta (A4) precursor protein b. (694 aa) |
| | iqce | IQ motif-containing E. (680 aa) |
| | tmod4 | Tropomodulin 4 (Muscle). (343 aa) |
| | dpm3 | Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa) |
| | ppp2r3a | Protein phosphatase 2, regulatory subunit B'', alpha. (520 aa) |
| | scxa | Scleraxis bHLH transcription factor a. (199 aa) |
| | actn2b | Actinin, alpha 2b. (894 aa) |
| | LOC101883396 | Artemin b. (189 aa) |
| | neb | Nebulin. (6177 aa) |
| | eya1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa) |
| | myo18aa | Myosin XVIIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2454 aa) |
| | cemip2 | Cell surface hyaluronidase; Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan. Acts as a regulator of angiogenesis in embryos by mediating degradation of extracellular hyaluronan, thereby promoting VEGF signaling. Acts as a regulator of heart development during myocardial and endocardial morphogenesis: involved in the looping stage of heart morphogenesis. Stimulates migration of endocardial cells and increases both myocardial and endocardial fusion. Involved in the restriction of endocardia [...] (1378 aa) |
| | selenon | Selenoprotein N; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Plays an important role [...] (557 aa) |
| | tnnt3b | Troponin T type 3b (skeletal, fast). (284 aa) |
| | tbxas1 | Thromboxane A synthase 1 (platelet); Belongs to the cytochrome P450 family. (546 aa) |
| | epg5 | Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity). (2532 aa) |
| | asxl1 | ASXL transcriptional regulator 1. (1619 aa) |
| | las1l | LAS1-like ribosome biogenesis factor. (580 aa) |
| | kctd10 | Potassium channel tetramerisation domain containing 10. (313 aa) |
| | dok7 | Docking protein 7. (695 aa) |
| | lamb2 | Laminin, beta 2 (laminin S). (1782 aa) |
| | met | MET proto-oncogene, receptor tyrosine kinase. (1382 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | mtm1 | Myotubularin 1. (639 aa) |
| | synpo2lb | Synaptopodin 2-like b. (1184 aa) |
| | rbm24b | RNA-binding motif protein 24b. (245 aa) |
| | ambra1b | Autophagy/beclin-1 regulator 1b. (1360 aa) |
| | cryabb | Crystallin, alpha B, b; Belongs to the small heat shock protein (HSP20) family. (165 aa) |
| | actc1b | Actin, alpha 1, skeletal muscle. (377 aa) |
| | rnf213a | E3 ubiquitin-protein ligase rnf213-alpha; E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of proteins downstream of rspo3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity (By similarity). Also involved in neuromuscular regulation. (5209 aa) |
| | sil1 | SIL1 nucleotide exchange factor. (463 aa) |
| | naa15b | N(alpha)-acetyltransferase 15, NatA auxiliary subunit b. (865 aa) |
| | smyd1b | SET and MYND domain-containing 1b. (486 aa) |
| | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] (448 aa) |
| | washc5 | WASH complex subunit 5; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. Belongs to the strumpellin family. (1021 aa) |
| | lamb1a | Laminin, beta 1a. (1785 aa) |
| | lama2 | Laminin, alpha 2. (845 aa) |
| | mymk | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. (220 aa) |
| | tln1 | Talin 1. (2544 aa) |
| | pyroxd1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily. (485 aa) |
| | hmgcrb | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa) |
| | sufu | Suppressor of fused homolog. (485 aa) |
| | vegfaa | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa) |
| | tpcn2 | Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction (By similarity). (774 aa) |
| | fkrp | Fukutin-related protein. (536 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | fbn2b | Fibrillin 2b. (2868 aa) |
| | scn4aa | Sodium channel protein type 4 subunit alpha A; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily. (1829 aa) |
| | mibp2 | Muscle-specific beta 1 integrin-binding protein 2. (203 aa) |
| | dnm2a | Dynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (860 aa) |
| | rbm24a | RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (230 aa) |
| | adss1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (456 aa) |
| | pggt1b | Protein geranylgeranyltransferase type I, beta subunit. (320 aa) |
| | dnm2b | Dynamin 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (432 aa) |
| | itgb1b | Integrin beta; Belongs to the integrin beta chain family. (521 aa) |
| | gne | Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase. (732 aa) |
| | zbtb42 | Zinc finger and BTB domain-containing 42. (463 aa) |
| | nfixa | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (432 aa) |
| | col22a1 | Collagen, type XXII, alpha 1. (1622 aa) |
| | krit1 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa) |
| | homer1b | Homer scaffold protein 1b. (398 aa) |
| | bmpr1ba | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa) |
| | qkia | Protein quaking-A; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (383 aa) |
| | capzb | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa) |
| | hspg2 | Heparan sulfate proteoglycan 2. (3462 aa) |
| | cbfb | Core-binding factor subunit beta. (201 aa) |
| | trip6 | Uncharacterized protein. (571 aa) |
| | acta2 | Actin, alpha 2, smooth muscle, aorta. (377 aa) |
| | npl | N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). (307 aa) |
| | pxna | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa) |
| | apobec2b | Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2b. (273 aa) |
| | msc | Musculin (activated B-cell factor-1). (160 aa) |
| | megf10 | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa) |
| | Itga7 | Uncharacterized protein. (156 aa) |
| | ripply1 | Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. (140 aa) |
| | plecb | Plectin b. (4535 aa) |
| | nphs1 | NPHS1 adhesion molecule, nephrin. (1287 aa) |
