STRINGSTRING
cdh2 cdh2 gli2a gli2a jag2b jag2b smo smo pink1 pink1 prdm12b prdm12b bmp7a bmp7a vldlr vldlr scn8aa scn8aa ptch1 ptch1 mdga2a mdga2a vangl2 vangl2 sim1a sim1a ift88 ift88 llgl2 llgl2 pax3a pax3a brd2a brd2a dicer1 dicer1 hdac1 hdac1 cxcl12a cxcl12a marcksl1a marcksl1a arl6ip1 arl6ip1 olig2 olig2 cxcr4b cxcr4b ackr3b ackr3b gdf6a gdf6a bves bves ogg1 ogg1 ctnnd2b ctnnd2b nrg2a nrg2a pbx4 pbx4 meox1 meox1 her3 her3 ttn.2 ttn.2 ascc1 ascc1 sox10 sox10 hoxb1a hoxb1a her8a her8a pax5 pax5 ppp1r12a ppp1r12a prickle1b prickle1b nhsl1b nhsl1b hnf1ba hnf1ba hoxb1b hoxb1b epb41l5 epb41l5 cyfip2 cyfip2 cib2 cib2 znf644b znf644b nrg1 nrg1 znf644a znf644a tsc2 tsc2 pcdh10b pcdh10b lama1 lama1 axin1 axin1 trip4 trip4 cdh1 cdh1 notch1a notch1a dab1a dab1a sox32 sox32 Reln Reln dctn1a dctn1a cntn2 cntn2 cc2d2a cc2d2a ndnf ndnf nkx2.2a nkx2.2a adgrl3.1 adgrl3.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
jag2bDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1254 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
pink1PTEN-induced kinase 1. (574 aa)
prdm12bPR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (366 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
vldlrVery low density lipoprotein receptor. (866 aa)
scn8aaSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1949 aa)
ptch1Protein patched homolog 1. (1475 aa)
mdga2aMAM domain-containing glycosylphosphatidylinositol anchor 2a. (957 aa)
vangl2Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa)
sim1aSingle-minded homolog 1-A; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (745 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
llgl2LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family. (1020 aa)
pax3aTranscription factor PAX3. (509 aa)
brd2aBromodomain-containing protein 2a. (836 aa)
dicer1Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1865 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
marcksl1aMARCKS-related protein 1-A; Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. (213 aa)
arl6ip1ADP-ribosylation factor-like 6-interacting protein 1. (203 aa)
olig2Oligodendrocyte lineage transcription factor 2. (273 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ackr3bAtypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family. (362 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
bvesBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa)
ogg18-oxoguanine DNA glycosylase. (391 aa)
ctnnd2bCatenin (cadherin-associated protein), delta 2b. (1210 aa)
nrg2aZgc:162973 protein. (488 aa)
pbx4Pre-B-cell leukemia transcription factor 4. (343 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
her3Hairy-related 3. (253 aa)
ttn.2Titin, tandem duplicate 2. (26265 aa)
ascc1Activating signal cointegrator 1 complex subunit 1. (249 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
hoxb1aHomeobox protein Hox-B1a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (316 aa)
her8aHairy-related 8a. (221 aa)
pax5Paired box 5. (396 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
prickle1bPrickle homolog 1b. (863 aa)
nhsl1bNHS-like 1b. (1527 aa)
hnf1baHepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa)
hoxb1bHomeobox protein Hox-B1b; Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments; Belongs to the Antp homeobox family. Labial subfamily. (229 aa)
epb41l5Erythrocyte membrane protein band 4.1-like 5. (461 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
znf644bZinc finger protein 644b. (1267 aa)
nrg1Neuregulin 1. (730 aa)
znf644aZinc finger protein 644a. (1169 aa)
tsc2TSC complex subunit 2. (1674 aa)
pcdh10bProtocadherin 10b. (1026 aa)
lama1Laminin, alpha 1. (3075 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
trip4Thyroid hormone receptor interactor 4. (564 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
dab1aDAB adaptor protein 1a. (586 aa)
sox32SRY-box transcription factor 32. (307 aa)
RelnReelin domain-containing protein. (259 aa)
dctn1aDynactin 1a. (1257 aa)
cntn2Contactin 2. (1040 aa)
cc2d2aCoiled-coil and C2 domain-containing 2A. (1675 aa)
ndnfNeuron-derived neurotrophic factor. (585 aa)
nkx2.2aHomeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa)
adgrl3.1Adhesion G protein-coupled receptor L3.1; Belongs to the G-protein coupled receptor 2 family. (1540 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.