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| | seh1l | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. (364 aa) |
| | ddx19 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast). (487 aa) |
| | eif2b1 | Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (291 aa) |
| | fxr2 | Fragile X mental retardation, autosomal homolog 2. (676 aa) |
| | eif4eb | Eukaryotic translation initiation factor 4eb; Belongs to the eukaryotic initiation factor 4E family. (216 aa) |
| | nup155 | Nucleoporin 155. (1391 aa) |
| | eif4bb | Eukaryotic translation initiation factor 4Bb. (569 aa) |
| | eef1a2 | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa) |
| | pnn | Pinin, desmosome-associated protein. (667 aa) |
| | eif3d | Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (552 aa) |
| | eif3c | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (926 aa) |
| | ube2ib | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | upf3b | UPF3B regulator of nonsense mediated mRNA decay. (467 aa) |
| | nmd3 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (505 aa) |
| | nup93 | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. (820 aa) |
| | rae1 | mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family. (368 aa) |
| | eif2b3 | Eukaryotic translation initiation factor 2B, subunit 3 gamma. (453 aa) |
| | snupn | Snurportin-1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family. (365 aa) |
| | ndc1 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity); Belongs to the NDC1 family. (671 aa) |
| | rpp14 | Ribonuclease P/MRP 14 subunit. (125 aa) |
| | nup50 | Nucleoporin 50. (422 aa) |
| | smn1 | Survival motor neuron protein 1; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites. (281 aa) |
| | rpp40 | Ribonuclease P 40 subunit like. (361 aa) |
| | eif3i | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (325 aa) |
| | eif4g2a | Eukaryotic translation initiation factor 4, gamma 2a. (891 aa) |
| | eif4a1b | Eukaryotic translation initiation factor 4A, isoform 1B; Belongs to the DEAD box helicase family. (406 aa) |
| | tprb | Translocated promoter region b, nuclear basket protein. (2352 aa) |
| | eif5 | Eukaryotic translation initiation factor 5. (429 aa) |
| | ncbp2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (155 aa) |
| | pabpc1a | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. (634 aa) |
| | thoc7 | THO complex subunit 7 homolog; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm v [...] (202 aa) |
| | tacc3 | Transforming, acidic coiled-coil-containing protein 3. (942 aa) |
| | nup58 | Nucleoporin 58. (567 aa) |
| | eif4e1b | Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein. (214 aa) |
| | nup133 | Nuclear pore complex protein Nup133; Involved in poly(A)+ RNA transport (By similarity). Involved in nephrogenesis. (1136 aa) |
| | nup88 | Nucleoporin 88; Component of the nuclear pore complex. (720 aa) |
| | eif2s1a | Eukaryotic translation initiation factor 2, subunit 1 alpha, like. (315 aa) |
| | rbm8a | RNA-binding protein 8A; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain [...] (174 aa) |
| | eif3g | Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (293 aa) |
| | eif2s3 | Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] (472 aa) |
| | acin1b | Apoptotic chromatin condensation inducer 1b. (1259 aa) |
| | eif4e1c | Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family. (213 aa) |
| | nup35 | Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity); Belongs to the Nup35 family. (308 aa) |
| | pabpc1b | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (634 aa) |
| | sumo3a | Small ubiquitin-related modifier 3-like; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity). (94 aa) |
| | rpp30 | Ribonuclease P/MRP 30 subunit. (265 aa) |
| | nup107 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (919 aa) |
| | casc3 | Protein CASC3; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs th [...] (754 aa) |
| | eif4ebp2 | Eukaryotic translation initiation factor 4E-binding protein 2. (113 aa) |
| | nup188 | Nucleoporin 188. (1732 aa) |
| | elac2 | ElaC ribonuclease Z 2. (819 aa) |
| | nup42 | Nucleoporin NUP42; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. (414 aa) |
| | sumo3b | Small ubiquitin-related modifier. (94 aa) |
| | ddx39b | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B. (435 aa) |
| | eif3hb | Eukaryotic translation initiation factor 3 subunit H-B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (333 aa) |
| | ube2ia | SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | pop7 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (148 aa) |
| | gemin8 | Gem (nuclear organelle)-associated protein 8. (217 aa) |
| | thoc6 | THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity); Belongs to t [...] (323 aa) |
| | fus | FUS RNA-binding protein. (541 aa) |
| | thoc5 | THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity); Belongs to t [...] (684 aa) |
| | magoh | Protein mago nashi homolog; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby infl [...] (147 aa) |
| | tardbp | TAR DNA-binding protein. (412 aa) |
| | eif4a1a | Eukaryotic translation initiation factor 4A, isoform 1A. (406 aa) |
| | rpp38 | Ribonuclease P/MRP 38 subunit. (265 aa) |
| | gemin7 | Gem (nuclear organelle)-associated protein 7. (125 aa) |
| | gemin4 | Gem (nuclear organelle)-associated protein 4. (1057 aa) |
| | eif2b2 | Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (355 aa) |
| | eif4ebp3l | Eukaryotic translation initiation factor 4E-binding protein 3-like; Regulates eif4e1a activity by preventing its assembly into the eIF4F complex; Belongs to the eIF4E-binding protein family. (112 aa) |
| | paip1 | Poly(A)-binding protein-interacting protein 1. (419 aa) |
| | rpp21 | Ribonuclease P 21 subunit. (165 aa) |
| | eif4ebp1 | Eukaryotic translation initiation factor 4E-binding protein 1. (120 aa) |
| | nup43 | Nucleoporin 43. (372 aa) |
| | sumo1 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as [...] (100 aa) |
| | phax | Phosphorylated adaptor for RNA export. (379 aa) |
| | cyfip1 | Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family. (1253 aa) |
| | elac1 | ElaC ribonuclease Z 1. (372 aa) |
| | eif1axa | Eukaryotic translation initiation factor 1A X-linked a; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (144 aa) |
| | eif2s1b | Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa) |
| | eif5b | Eukaryotic translation initiation factor 5B. (1265 aa) |
| | eif2s2 | Eukaryotic translation initiation factor 2, subunit 2 beta. (327 aa) |
| | eif3jb | Eukaryotic translation initiation factor 3 subunit J-B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (264 aa) |
| | pop5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (169 aa) |
| | sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) |
| | eif4ebp3 | Eukaryotic translation initiation factor 4E-binding protein 3. (104 aa) |
| | nxf1 | Nuclear RNA export factor 1. (642 aa) |
| | rangap1b | Ran GTPase-activating protein 1b. (576 aa) |
| | thoc3 | THO complex 3. (322 aa) |
| | eif4g2b | Eukaryotic translation initiation factor 4, gamma 2b. (898 aa) |
| | sap18 | Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins. (153 aa) |
| | eif1axb | Eukaryotic translation initiation factor 1A X-linked b; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (144 aa) |
| | eif4g1a | Eukaryotic translation initiation factor 4 gamma, 1a. (1585 aa) |
| | prmt5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (631 aa) |
| | rangap1a | RAN GTPase-activating protein 1a. (570 aa) |
| | nup210 | Nucleoporin 210. (1873 aa) |
| | taf15 | TAF15 RNA polymerase II, TATA box-binding protein (TBP)-associated factor. (434 aa) |
| | rpp25l | Ribonuclease P/MRP 25 subunit-like. (224 aa) |
| | si:dkey-37o8.1 | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (483 aa) |
| | thoc2 | THO complex 2. (1560 aa) |
| | trnt1 | tRNA nucleotidyl transferase, CCA-adding, 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (431 aa) |
| | eif2b5 | Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (607 aa) |
| | senp2 | SUMO-specific peptidase 2. (598 aa) |
| | nup214 | Nucleoporin 214. (1218 aa) |
| | eif3s10 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1267 aa) |
| | xpo1a | Exportin 1 (CRM1 homolog, yeast) a. (1071 aa) |
| | eif4ea | Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. (215 aa) |
| | eef1a1a | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa) |
| | eif4a2 | Eukaryotic translation initiation factor 4A, isoform 2; Belongs to the DEAD box helicase family. (411 aa) |
| | fmr1 | FMRP translational regulator 1. (569 aa) |
| | thoc1 | THO complex 1. (655 aa) |
| | eif2b4 | Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (540 aa) |
| | eif3ea | Eukaryotic translation initiation factor 3 subunit E-A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (446 aa) |
| | eif4e2 | Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (236 aa) |
| | pom121 | POM121 transmembrane nucleoporin. (1201 aa) |
| | nup205 | Nucleoporin 205. (2001 aa) |
| | ran | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (215 aa) |
| | zgc:153681 | Zgc:153681. (610 aa) |
| | strap | Serine/threonine kinase receptor-associated protein. (329 aa) |
| | pabpc1l | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (620 aa) |
| | nup98 | Nucleoporin 98. (1814 aa) |
| | gle1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa) |
| | gemin5 | Gem (nuclear organelle)-associated protein 5. (1440 aa) |
| | nup62l | Nucleoporin 62-like. (507 aa) |
| | eif4g3b | Eukaryotic translation initiation factor 4 gamma, 3b. (1699 aa) |
| | upf3a | Regulator of nonsense transcripts 3A; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity); Belongs to the RENT3 family. (478 aa) |
| | eif1 | Eukaryotic translation initiation factor 1B. (113 aa) |
| | acin1a | Apoptotic chromatin condensation inducer 1a. (572 aa) |
| | eef1a1b | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa) |
| | eif1b | Zgc:56676. (113 aa) |
| | zgc:193690 | Zgc:193690. (492 aa) |
| | fxr1 | Fragile X mental retardation, autosomal homolog 1. (645 aa) |
| | srrm1 | Serine/arginine repetitive matrix 1. (896 aa) |
| | eif3ja | Eukaryotic translation initiation factor 3 subunit J-A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (249 aa) |
| | cyfip2 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa) |
| | eif3f | Eukaryotic translation initiation factor 3, subunit F; Belongs to the eIF-3 subunit F family. (282 aa) |
| | eif3ba | Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family. (681 aa) |
| | eif3ha | Eukaryotic translation initiation factor 3 subunit H-A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (335 aa) |
| | aaas | Achalasia, adrenocortical insufficiency, alacrimia. (499 aa) |
| | pop1 | POP1 homolog, ribonuclease P/MRP subunit. (455 aa) |
| | nup54 | Nucleoporin 54. (353 aa) |
| | nup85 | Nuclear pore complex protein Nup85; Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Involved in nephrogenesis (By similarity). (412 aa) |
| | rnps1-2 | RNA-binding protein with serine-rich domain 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA a [...] (283 aa) |
| | eif4e2rs1 | Eukaryotic translation initiation factor 4E family member 2-related sequence 1; Belongs to the eukaryotic initiation factor 4E family. (228 aa) |
| | clns1a | Chloride channel, nucleotide-sensitive, 1A. (249 aa) |
| | rpp25a | Alba domain-containing protein. (204 aa) |
| | eif4ba | Eukaryotic translation initiation factor 4Ba. (616 aa) |
| | kpnb1 | Karyopherin (importin) beta 1. (876 aa) |
| | eif4a3 | Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (406 aa) |
| | XPO5 | Si:ch211-233m11.2. (906 aa) |
| | pym1 | Partner of Y14 and mago; Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon- exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translatio [...] (194 aa) |
| | sumo2b | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are al [...] (96 aa) |
| | pop4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (219 aa) |
| | xpot | Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. Belongs to the exportin family. (971 aa) |
| | alyref | Aly/REF export factor. (291 aa) |
| | pabpc4 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (637 aa) |
| | tpra | Translocated promoter region a, nuclear basket protein. (2363 aa) |
| | nup153 | Nucleoporin 153. (1436 aa) |
| | nxt2 | Nuclear transport factor 2-like export factor 2. (137 aa) |
| | gemin6 | Gem (nuclear organelle)-associated protein 6. (137 aa) |
| | eif4g3a | Eukaryotic translation initiation factor 4 gamma, 3a. (1711 aa) |
| | ddx20 | Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are trapped in an inactive complex. The SMN complex triggers the assembly of core snRNPs and their transport to the nucleus. May also pla [...] (811 aa) |
| | tgs1 | LYN proto-oncogene, Src family tyrosine kinase. (800 aa) |
| | nup160 | Nucleoporin 160. (1171 aa) |
| | eef1a1l1 | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa) |
| | gemin2 | Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (261 aa) |
| | xpo1b | Exportin 1 (CRM1 homolog, yeast) b. (1081 aa) |
| | nup37 | Nucleoporin 37. (326 aa) |
| | RANBP2 | Si:ch1073-55a19.2. (2953 aa) |
| | upf1 | UPF1 RNA helicase and ATPase. (1100 aa) |
| | rpp25b | Ribonuclease P and MRP subunit p25, b. (335 aa) |
